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Figure 1: Proposed model (a) Melanosome content: the melanocyte could transfer melanin as well as non-pigment molecules, the latter including messenger RNA (b) Detoxification: the entrance of genotoxic agents to the skin, whether from the environment or the bloodstream, activates cycles of detoxification involving the MDR ABCB5 pump, in which this agent enters the melanocyte, then is packaged in the melanosome and tranfered to keratinocytes. Thus during chemotherapy, in the microenvironment of the melanoma tumor, the malignant melanocyte could transfer the molecules of the cancer therapy to neighboring cells (such a fibroblasts) by means of the MDR ABCB5 pump that is harbored in the membrane the melanosomes

Figure 1: Proposed model (a) Melanosome content: the melanocyte could transfer melanin as well as non-pigment molecules, the latter including messenger RNA (b) Detoxification: the entrance of genotoxic agents to the skin, whether from the environment or the bloodstream, activates cycles of detoxification involving the MDR ABCB5 pump, in which this agent enters the melanocyte, then is packaged in the melanosome and tranfered to keratinocytes. Thus during chemotherapy, in the microenvironment of the melanoma tumor, the malignant melanocyte could transfer the molecules of the cancer therapy to neighboring cells (such a fibroblasts) by means of the MDR ABCB5 pump that is harbored in the membrane the melanosomes