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   2010| January-February  | Volume 76 | Issue 1  
    Online since January 6, 2010

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Efficacy of low-dose isotretinoin in acne vulgaris
Kabir Sardana, Vijay K Garg
January-February 2010, 76(1):7-13
DOI:10.4103/0378-6323.58672  PMID:20061724
Low-dose isotretinoin (0.5 mg/kg/day) is a mode of therapy for mild to moderate grades of acne.We analyzed the various trials of this mode of therapy with or without combination with topical agents.We also statistically analyzed the results, efficacy and relapse rates of standard therapy in comparison with the low-dose therapy. Our analysis of the data revealed that the efficacy and relapse rates of low-dose isotretinoin in mild to moderate grades of acne is comparable with the standard regimen (1 mg/kg/day), which is given in the severe grade of acne vulgaris. Thus, the grade of acne vulgaris should dictate the dose of administration of isotretinoin and the standard dose of 1 mg/kg/day is an unnecessary overtreatment for mild to moderate grades of acne.
  40,406 912 17
The effects of a daily facial lotion containing vitamins B3 and E and provitamin B5 on the facial skin of Indian women: A randomized, double-blind trial
Hemangi R Jerajani, Haruko Mizoguchi, James Li, Debora J Whittenbarger, Michael J Marmor
January-February 2010, 76(1):20-26
DOI:10.4103/0378-6323.58674  PMID:20061726
Background : The B vitamins niacinamide and panthenol have been shown to reduce many signs of skin aging, including hyperpigmentation and redness. Aims : To measure the facial skin effects in Indian women of the daily use of a lotion containing niacinamide, panthenol, and tocopherol acetate using quantitative image analysis. Methods : Adult women 30-60 years of age with epidermal hyperpigmentation were recruited in Mumbai and randomly assigned to apply a test or control lotion to the face daily for 10 weeks. Effects on skin tone were measured using an image capturing system and associated software. Skin texture was assessed by expert graders. Barrier function was evaluated by transepithelial water loss measurements. Subjects and evaluators were blinded to the product assignment. Results : Of 246 women randomized to treatment, 207 (84%) completed the study. Women who used the test lotion experienced significantly reduced appearance of hyperpigmentation, improved skin tone evenness, appearance of lightening of skin, and positive effects on skin texture. Improvements versus control were seen as early as 6 weeks. The test lotion was well tolerated. The most common adverse event was a transient, mild burning sensation. Conclusions : Daily use of a facial lotion containing niacinamide, panthenol, and tocopheryl acetate improved skin tone and texture and was well tolerated in Indian women with facial signs of aging.
  23,642 343 15
Skin-lightening agents: New chemical and plant extracts -ongoing search for the holy grail!
Garehatty Rudrappa Kanthraj
January-February 2010, 76(1):3-6
DOI:10.4103/0378-6323.58671  PMID:20061723
  21,758 1,123 6
Relapsing polychondritis - delayed diagnosis and fatal outcome
Krina Patel
January-February 2010, 76(1):67-69
DOI:10.4103/0378-6323.58688  PMID:20061740
  10,563 102 -
Comparative study of clinical efficacy with amitriptyline, pregabalin, and amitriptyline plus pregabalin combination in postherpetic neuralgia
Arun Achar, Gobinda Chatterjee, Tapobrata Guha Ray, Biswanath Naskar
January-February 2010, 76(1):63-65
DOI:10.4103/0378-6323.58686  PMID:20061738
  9,155 336 5
Retapamulin: A novel topical antibiotic
H Nagabushan
January-February 2010, 76(1):77-79
DOI:10.4103/0378-6323.58693  PMID:20061745
  8,773 692 6
Human papillomaviruses vaccine: A dermatologic perspective
Anita K Satyaprakash, Stephen K Tyring
January-February 2010, 76(1):14-19
DOI:10.4103/0378-6323.58673  PMID:20061725
Human papillomaviruses (HPV) are responsible for both benign anogenital warts and malignant disease in humans, especially cervical cancer. Dermatologists in India recognize a great many cases of anogenital warts, and afflicted individuals may be at increased risk of coinfection with oncogenic HPV types. For this reason, dermatologists are in a position to identify potential carriers of oncogenic HPV types in the population. By targeting these individuals and their partners, as well as unaffected individuals for vaccination with the quadrivalent HPV vaccine, dermatologists have the ability to impact the morbidity and mortality of cervical cancer in India.
  7,791 858 3
Reticular erythematous mucinosis syndrome with telangiectasias
Ayse Serap Karadag, Gulcin Guler Simsek
January-February 2010, 76(1):86-86
DOI:10.4103/0378-6323.58697  PMID:20061752
  8,237 91 2
Hyperkeratotic pitted plaques on the palms and soles
Sujay Khandpur, Sushruta D Kathuria, Ruchika Gupta, Manoj K Singh, Vinod K Sharma
January-February 2010, 76(1):52-55
DOI:10.4103/0378-6323.58680  PMID:20061732
Lichen planus (LP) and lichen nitidus (LN) present with varied morphology on the palms and soles. We present four unusual cases of palmoplantar LP and LN manifesting as hyperkeratotic plaques with pits. The diagnosis was confirmed histologically. Subtle features like presence of violaceous border suggests LP and plugs within the pits suggest LN.
  7,978 232 3
Linear epidermolytic acanthoma of vulva: An unusual presentation
Molly Thomas, Renu George, Meera Thomas
January-February 2010, 76(1):49-51
DOI:10.4103/0378-6323.58679  PMID:20061731
Epidermolytic acanthoma (EA) is a rare benign tumor that shows epidermolytic hyperkeratosis (EH) on histopathology. It can occur in a solitary or disseminated form. This condition needs to be distinguished from other hereditary or acquired conditions that may show EH. We diagnosed an unusual case of EA of the vulva presenting in a linear pattern in a 50-year-old lady based on the clinical features and typical histopathological findings and stress the importance of considering epidermolyic acanthoma in the differential diagnosis of verrucous lesions of the genitalia.
  7,249 136 6
Generalized granuloma annulare with tuberculoid granulomas: A rare histopathological variant
Sekar C Shanmuga, Reena Rai, A Laila, S Shanthakumari, V Sandhya
January-February 2010, 76(1):73-75
DOI:10.4103/0378-6323.58691  PMID:20061743
  6,920 104 -
Lichen sclerosus: Role of occlusion of the genital skin in the pathogenesis
Somesh Gupta, Amit Kumar Malhotra, C Ajith
January-February 2010, 76(1):56-58
DOI:10.4103/0378-6323.58681  PMID:20061733
Lichen sclerosus (LS) is a chronic inflammatory skin disease, which most commonly involves the anogenital region. The etiology of LS is obscure, but genetic susceptibility, autoimmune mechanisms, infective agents like human papillomavirus and spirochaetes, and Koebner phenomenon has been postulated as causative factors. We report our observation in 6 patients (3 males and 3 females) with histologically proven lichen sclerosus that showed relative sparing of the uncovered areas of the genitals, thereby suggesting that the occlusion of the genital skin may be playing a greater role in the causation of LS than is currently thought, in both sexes.
  6,837 166 8
Updosing of antihistamines to improve control of chronic urticaria
Kiran V Godse
January-February 2010, 76(1):61-62
DOI:10.4103/0378-6323.58684  PMID:20061736
  6,448 259 3
Clinico-allergological pattern of allergic contact dermatitis among 70 Indian children
Nilendu Sarma, Sanjay Ghosh
January-February 2010, 76(1):38-44
DOI:10.4103/0378-6323.58677  PMID:20061729
Background: Rapid urbanization, westernization of lifestyles, poor quality of objects available and extremely relaxed vigilance on adherence to 'product safety guidelines' make any developing country like India highly susceptible to allergic contact dermatitis (ACD) even in children. There has been no previous attempts to assess the magnitude of childhood ACD in India. Aims: To assess the clinico-allergological profile of ACD in Indian children. Methods: All consecutive children up to 15 completed years of age who were patch tested over the last 3 years were analyzed from the records. Results: A total of 70 children were studied (average age of disease onset 8.39±3.59 years [SD], range 1-15 years and average age of presentation 10.8 ± 2.99 years [SD], range 5-15 years). Relevant allergy was noted in 48.6% of the patients. Age and sex had no significant role on the prevalence of ACD. Common allergens were paraben (43%), potassium dichromate (27%) and fragrance mix (26%). Most relevant allergens were potassium dichromate, paraben and fragrance. Foot was the most commonly involved site (25.7% of patients). Atopy was present in 18 patients (25.7%). A total of 22 irritant reactions were noted in 13 patients. Conclusion: This study reflects the current status of childhood ACD of this region.
  6,265 361 4
A family of Unna-Thost disease with one of them showing findings of epidermolytic keratoderma
Ayse Serap Karadag, Gulcin Guler Simsek
January-February 2010, 76(1):85-85
DOI:10.4103/0378-6323.58699  PMID:20061749
  6,468 102 3
Lupoid cutaneous leishmaniasis: A report of 16 cases
Arfan Ul Bari, Naeem Raza
January-February 2010, 76(1):85-85
DOI:10.4103/0378-6323.58698  PMID:20061750
Background: Lupoid cutaneous leishmaniasis (CL) is known as the chronic form of CL. However, keeping its clinical presentation in view, there is a need to revisit this form of disease. Aims: To redefine/describe lupoid CL in view of clinical features. Methods: It was a case series seen in Muzaffarabad (Pakistan) from Jan 2006 to May 2008. All patients clinically suggestive and consistent with laboratory diagnosis of CL were registered. Patients of all age groups and either sex having cutaneous lesions resembling lupus vulgaris or lupus erythematosus on the face or elsewhere were included in the study. Those having chronic fluctuating/relapsing course or scarring within the lesions were also included. Various demographic features of the patients and clinical patterns were recorded. Descriptive statistics were used for analysis. Results: Of 254 registered patients of CL, 16 (6.3%) were diagnosed as lupoid CL. None of the patients had scarred lesions. Age ranged from 38 to 75 (55 + 15.11) years and duration of lesions varied from 4 to 32 (14.25 + 07.59) weeks. All patients had lesions over the face. Thirteen (81.25%) had a large solitary plaque extending over the nose and a large part of the cheeks and three (18.75%) had multiple lesions. Lesions were central/nasal in two (12.5%), unilateral/asymmetrical in four (25%) and bilateral/symmetrical in 10 (62.5%). Morphological patterns included erythematous/infiltrated (7), psoriasiform (6), ulcerated/crusted (2) and Discoid lupus erythematosus (DLE)[G1] like (1). Conclusion: Lupoid CL is not strictly a chronic form of disease, which presents on the face from the very onset and shows no scarring or recurrence.
  6,222 158 11
Comparison of enzyme-linked immunosorbent assay test with immunoblot assay in the diagnosis of pemphigus in Indian patients
Sujay Khandpur, Vinod K Sharma, Alpana Sharma, Gaurav Pathria, Abhigyan Satyam
January-February 2010, 76(1):27-32
DOI:10.4103/0378-6323.58675  PMID:20061727
Background: The diagnosis of pemphigus vulgaris (PV) and pemphigus foliaceous (PF) rests upon clinical, histological and immunofluorescence features. Enzyme-linked immunosorbent assay (ELISA) test and immunoblot (IB) assay have shown variable sensitivity and specificity. Aims: We compared the utility of ELISA and IB in pemphigus patients. Methods: Sixty-six pemphigus cases (PV-54, PF-12) and 72 controls (other vesicobullous disorders and healthy controls) were inducted. ELISA for anti-Dsg 3 and 1 antibodies and IB assay were performed. Results: On ELISA, both mean anti-Dsg 1 and 3 titers were raised in PV and PF. Mean anti-Dsg 1 in mucocutaneous PV was significantly higher than in mucosal PV and mean anti-Dsg 3 was significantly raised in PV than in PF. Anti-Dsg 1 and 3 in the control group were negative. Sensitivity and specificity of ELISA in PV was 98.14% and 90.5% while in PF it was 91.6% and 61.1%, respectively.On IB in PV, 36 cases (66.67%) showed the 130 kDa and 160 kDa antigen bands, 12 (22.2%) only the 130 kDa and six (11.1%) only the 160 kDa band. Eight of the nine pure mucosal cases (88.8%) showed only the 130 kDa. In PF, only the 160 kDa antigen was detected. These antigens were not identified in the control group. Sensitivity and specificity of IB in PV was 88.9% and 100% and in PF it was 100% and 95.2%, respectively. Conclusion: Both tests could differentiate pemphigus from other dermatoses, including other blistering disorders. ELISA could not make a distinction between PV and PF or between the various clinical phenotypes of PV. IB differentiated between PV and PF and the different clinical variants of PV.
  5,143 301 5
Chronic tophaceous gout with severe deforming arthritis
Sujay Khandpur, Anil K.V Minz, Vinod K Sharma
January-February 2010, 76(1):69-71
DOI:10.4103/0378-6323.58689  PMID:20061741
  5,051 109 2
Atypical cutaneous lesions of Penicillium marneffei infection as a manifestation of the immune reconstitution inflammatory syndrome after highly active antiretroviral therapy
Lahari Saikia, Reema Nath, Debeeka Hazarika, J Mahanta
January-February 2010, 76(1):45-48
DOI:10.4103/0378-6323.58678  PMID:20061730
Penicillium marneffei infections normally manifest as molluscum contagiosum like skin lesion in HIV-infected persons. We report a case with verrucous lesions over nose and face due to Penicillium marneffei infection after HAART treatment. A 28-year-old man presented, after two weeks of HAART treatment, with multiple erythematous, scaly, papules and nodules with central necrosis predominantly in face and both extremities and scrotum. Microbiological investigations confirmed the diagnosis of Penicillium marneffei infection. This is perhaps the first case report with such manifestation due to Penicillium marneffei infection.
  4,769 173 11
Serum iron and ferritin levels in Behçet's disease
Muzeyyen Gonul, Ulker Gul, Seray Kulcu Cakmak, Secil Soylu, Arzu Kilic
January-February 2010, 76(1):85-85
DOI:10.4103/0378-6323.58700  PMID:20061748
  4,742 77 2
Behavioral surveillance survey regarding human immunodeficiency virus/acquired immunodeficiency syndrome among high school and junior college students
SB Bhosale, SL Jadhav, Samir A Singru, Amitav Banerjee
January-February 2010, 76(1):33-37
DOI:10.4103/0378-6323.58676  PMID:20061728
Background and Aims: It is necessary to know the baseline knowledge, attitude, and practices about human immunodeficiency virus/acquired immunodeficiency syndrome among young people and the changes in these with intervention to guide prevention efforts. Methods: A cross-sectional pre- and post-survey with health education as a method of intervention was carried out in four different randomly selected schools and junior colleges among the Class IX-XII students of both sex. Instrument developed by the World Health Organization (WHO)/UNAIDS in their best practice recommendations was used for data collection. Results: Knowledge about all correct methods was present in 61.23% of the respondents. Knowledge of at least two methods of prevention was present in 70.31% of the respondents. Misconceptions about prevention were that good diet (33.42%), avoiding mosquito bite (49.71%) and avoiding public toilets (65.14%) could help in the prevention. With intervention, there was an improvement in the knowledge. However, the proportion of students with misconceptions did not come down. Correct knowledge about two methods of prevention also did not reach the WHO recommendation of 90%. Conclusion: It is very difficult to change the attitude and practices by a single health educational intervention and an ongoing behavior change communication is recommended.
  4,533 167 2
A rare association of acanthosis nigricans with Crouzon syndrome
Ajay Kumar Gupta, Sankha Koley, Sanjiv Choudhary, Arvind Bhake, Vikrant Saoji, Atul Salodkar
January-February 2010, 76(1):65-67
DOI:10.4103/0378-6323.58687  PMID:20061739
  4,294 112 2
Multiple asymptomatic verrucous plaques over the legs
Pradeep Vittal Bhagwat, Raghavendra S Tophakhane, Chandramohan Kudligi, Tonita Noronha
January-February 2010, 76(1):86-86
DOI:10.4103/0378-6323.58707  PMID:20061751
  3,955 173 2
Current best evidence from dermatology literature
Rashmi Jindal, Dipankar De
January-February 2010, 76(1):87-91
  3,973 139 1
Multiple erythematous papules on the pinna
Veeranna Shastry, Vijaya
January-February 2010, 76(1):83-84
DOI:10.4103/0378-6323.58696  PMID:20061747
  3,498 178 -
Clinico-epidemiological study of lichen urticatus
Lata Sharma, LS Solanki
January-February 2010, 76(1):62-63
DOI:10.4103/0378-6323.58685  PMID:20061737
  3,480 103 1
Relevance of patch testing in hand eczema-comment
Uma Shankar Agarwal, Gauri G Panse
January-February 2010, 76(1):59-60
DOI:10.4103/0378-6323.58682  PMID:20061734
  3,357 187 -
Penicillium marneffei infection in Assam
Lahari Saikia, Reema Nath, J Mahanta
January-February 2010, 76(1):75-76
DOI:10.4103/0378-6323.58692  PMID:20061744
  3,410 99 2
Naevoid basal cell carcinoma syndrome
Zabihollah Shahmoradi, Fateme Andalib, Amir Hossein Siadat
January-February 2010, 76(1):71-73
DOI:10.4103/0378-6323.58690  PMID:20061742
  3,267 145 -
What if your dissertation aims fail?
Bell Raj Eapen
January-February 2010, 76(1):80-82
DOI:10.4103/0378-6323.58694  PMID:20061746
  3,046 209 -
New initiatives of IJDVL in the year 2009
Devinder Mohan Thappa
January-February 2010, 76(1):1-2
DOI:10.4103/0378-6323.58670  PMID:20061722
  2,713 130 -
Tackling polyauthoritis giftosa
Anant Bhan
January-February 2010, 76(1):60-61
DOI:10.4103/0378-6323.58683  PMID:20061735
  2,512 97 1
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