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   2009| November-December  | Volume 75 | Issue 6  
    Online since November 12, 2009

 
 
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RESIDENTS CORNER
Nail pitting and onycholysis
Vikrant M Jadhav, Pradeep M Mahajan, Chandrakant B Mhaske
November-December 2009, 75(6):631-633
DOI:10.4103/0378-6323.57740  PMID:19915259
  19,385 1,056 6
ORIGINAL ARTICLES
Association of HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome among Indians
Timir Y Mehta, Laxman M Prajapati, Bharti Mittal, Chaitanya G Joshi, Jayesh J Sheth, Dinesh B Patel, Dinkar M Dave, Ramesh K Goyal
November-December 2009, 75(6):579-582
DOI:10.4103/0378-6323.57718  PMID:19915237
Background: Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis are severe cutaneous reactions caused by certain drugs, including antiepileptic carbamazepine. A strong association has been reported between human leucocyte antigen (HLA)-B*1502 and carbamazepine-induced SJS in Han Chinese patients. European studies suggested that HLA-B*1502 is not a universal marker but is ethnicity-specific for Asians. Aim: To study the association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients. Methods: Eight individuals who fulfilled the diagnostic criteria of SJS induced by carbamazepine were identified and HLA-B molecular typing was performed. HLA-B genotyping was carried out by polymerase chain reaction using sequence-specific primers. Results: Out of eight patients studied for genotype, six patients were found to have the HLA-B*1502 allele. Conclusion: This study suggests an association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients.
  17,606 465 129
REVIEW ARTICLE
Newer trends in the management of genital herpes
Amiya Kumar Nath, Devinder Mohan Thappa
November-December 2009, 75(6):566-574
DOI:10.4103/0378-6323.57716  PMID:19915235
Management of genital herpes is complex. Apart from using the standard antivirals, an ideal management protocol also needs to address various aspects of the disease, including the psychological morbidity. Oral acyclovir, valacyclovir or famciclovir are recommended for routine use. Long-term suppressive therapy is effective in reducing the number of recurrences and the risk of transmission to others. Severe or disseminated disease may require intravenous therapy. Resistant cases are managed with foscarnet or cidofovir. Genital herpes in human immunodeficiency virus-infected individuals usually needs a longer duration of antiviral therapy along with continuation of highly active anti retroviral therapy (HAART). Genital herpes in late pregnancy increases the risk of neonatal herpes. Antiviral therapy and/or cesarean delivery are indicated depending on the clinical circumstance. Acyclovir appears to be safe in pregnancy. But, there is limited data regarding the use of valacyclovir and famciclovir in pregnancy. Neonatal herpes requires a higher dose of acyclovir given intravenously for a longer duration. Management of the sex partner, counseling and prevention advice are equally important in appropriate management of genital herpes. Vaccines till date have been marginally effective. Helicase-primase inhibitors, needle-free mucosal vaccine and a new microbicide product named VivaGel may become promising treatment options in the future.
  15,552 1,272 2
LETTERS TO THE EDITOR
An unusual case of dermatitis herpetiformis presenting with initial scalp localization
Ulker Gul, Secil Soylu, Aylin Okcu Heper
November-December 2009, 75(6):620-622
DOI:10.4103/0378-6323.57734  PMID:19915253
  12,869 104 4
FOCUS
Phototherapy: An update
Reena Rai
November-December 2009, 75(6):634-637
DOI:10.4103/0378-6323.57741  PMID:19915260
  9,630 1,143 1
BRIEF REPORT
Autoimplantation therapy for multiple warts
V Shivakumar, Rajendra Okade, V Rajkumar
November-December 2009, 75(6):593-595
DOI:10.4103/0378-6323.57721  PMID:19915240
Background: In the treatment of multiple warts, there is no single treatment that is 100% effective and different modalities of treatment need to be combined. Aim: To evaluate the efficacy of homologous autoimplantation therapy in the treatment of multiple warts. Methods: A total of 60 patients of multiple verruca vulgaris and palmo-plantar warts were enrolled. Homologous autoimplantation was done after harvesting full-depth wart tissue. Patients were followed upto a period of 6 months. Resolution of warts within a period of 3 months after procedure was considered successful. Results: All the 60 patients were available for follow-up. A total of 28 patients of verruca vulgaris (70%) and 16 patients of palmo-plantar warts (80%) showed resolution of warts within 3 months, accounting for a total clearance rate of 73.3%. Majority of the responders (91%) showed resolution of warts within 2 months. Conclusion: This study demonstrates that homologous autoimplantation could be an effective, simple modality of treatment for multiple warts.
  9,761 652 2
ORIGINAL ARTICLES
Does circumcision influence recurrences in herpes genitalis?
VP Jerath, Vikram K Mahajan
November-December 2009, 75(6):575-578
DOI:10.4103/0378-6323.57717  PMID:19915236
Background and Aims: The effect of therapeutic circumcision in men for preventing recurrences of herpes genitalis remains largely unelucidated despite its well documented albeit conflicting role in reducing the risk of acquiring sexually transmitted infections, including genital herpes. Methods: Twenty volunteer adult males with a history of recurrent herpes genitalis were included in the study after informed consent and circumcision was carried out. Twenty more adult males having recurrent herpes genitalis and registered in the clinic during the same period were selected as controls. All patients and controls were followed-up for recurrences of herpes genitalis. Results and Conclusions: Six patients and six controls did not follow-up. Seven patients reported no recurrences during 3-18 years, seven patients had two to six recurrences during 11-27 years of postcircumcision follow-up, 0.0080 (average) recurrences per person per year as compared with 0.20 (average) recurrences per person per year recorded before the circumcision. Two patients had first recurrence 11 years after the circumcision. In comparison, 14 controls had 0.17 (average) recurrences per person per year, comparable with the number of recurrences in uncircumcised patients, and frequently at shorter intervals. Despite being a small study, the circumcision appears to reduce the number of recurrences on an average and evidently prolongs the disease-free period in between two recurrences.
  9,411 183 2
NET CASE
Generalized pustular psoriasis of pregnancy successfully treated with cyclosporine
Debeeka Hazarika
November-December 2009, 75(6):638-638
DOI:10.4103/0378-6323.57743  PMID:19915261
Two multigravidae aged 27 and 29 years, with previous uneventful pregnancies, second being psoriatic, reported at 24 and 28 weeks of pregnancies, with generalized pustular lesions. Laboratory findings, including serum calcium were normal. Ultrasonography showed normal fetal growth. Histopathology confirmed pustular psoriasis. Patients were put on cyclosporine 3 mg/ kg weight/ day after failure of an initial systemic steroid. Blood pressure, pulse, and fetal heart sounds were recorded every 12 hours, and ultrasonography and blood parameters, biweekly. Cyclosporine was tapered and stopped after delivery of two healthy babies at 38 weeks. We conclude that cyclosporine can be an option in the management of pustular psoriasis of pregnancy or psoriasis with pustulation in pregnancy.
  8,798 266 10
EDITORIAL
Emerging trends in viral sexually transmitted infections in India
Jyoti Dhawan, Sujay Khandpur
November-December 2009, 75(6):561-565
DOI:10.4103/0378-6323.57715  PMID:19915234
  6,927 515 1
LETTERS TO THE EDITOR
Outcome of Stevens Johnson syndrome and toxic epidermal necrolysis treated with corticosteroids
Arpana Rijal, S Agrawal
November-December 2009, 75(6):613-614
DOI:10.4103/0378-6323.57729  PMID:19915248
  5,779 265 3
NET LETTERS
Bilateral aberrant axillary breast tissue
Reza Yaghoobi, Nooshin Bagherani, Fateme Mohammadpour
November-December 2009, 75(6):639-639
DOI:10.4103/0378-6323.57745  PMID:19915264
  5,787 104 2
ORIGINAL ARTICLES
Prescription auditing of griseofulvin in a tertiary care teaching hospital
M Hepsi Bai Kirubha
November-December 2009, 75(6):588-592
DOI:10.4103/0378-6323.57720  PMID:19915239
Background: Griseofulvin has been the mainstay of treatment for dermatophytosis since many years. Since it is a penicillium antibiotic and used commonly in the outpatient department, the prescription should be audited for its safety and quality. Clinical pharmacists being an important member of the healthcare system have an immense responsibility in delivering pharmaceutical care by auditing prescriptions in order to achieve rational and cost-effective medical care thereby improving patient's Quality of Life (QOL). Aims: To study the utilization of griseofulvin by auditing prescriptions, to assess the impact of griseofulvin on the QOL of patients and to emphasize role and responsibilities of a clinical pharmacist in the treatment outcome of dermatophytosis. Methods: 120 patients prescribed with griseofulvin in the dermatology outpatient department were included in the study. On the basis of therapeutic response, improvement was graded at the end of the treatment regimen. Adverse drug reactions (ADRs) during the treatment period were recorded. Laboratory investigations were performed at baseline and at the end of treatment. Quality of Life was measured at baseline and at the end of therapy. Results: 56.7% were females and 43.3% were males. The most common diagnosis was tinea corporis (44.17%) followed by tinea cruris (14.17%) and onychomycosis (9.17%). The most common ADR due to griseofulvin was headache (5.83%). 64.20% patients had complete cure following treatment with griseofulvin. The overall QOL score improved significantly following treatment with griseofulvin (P < 0.0001). Conclusion: Griseofulvin can be used extensively for the treatment of dermatophytosis as it has no serious adverse effects and has higher cure rates. Treatment with griseofulvin significantly improves the QOL in patients with dermatophytosis.
  4,986 260 2
CASE REPORTS
Cutaneous zygomycosis: A possible postoperative complication in immunocompetent individuals
Ragini Tilak, Prabhat Raina, Sanjeev Kumar Gupta, Vijai Tilak, Pradyot Prakash, Anil Kumar Gulati
November-December 2009, 75(6):596-599
DOI:10.4103/0378-6323.57722  PMID:19915241
Fungi in the class of zygomycetes usually produce serious infections in diabetics and immunocompromised hosts. Cutaneous zygomycosis is a less common form, with an unpredictable extent of anatomical involvement and clinical course. Here, we report two cases of primary cutaneous zygomycosis as postoperative complications in otherwise healthy females. Zygomycosis was suspected and specimens from the surgical debridement were examined by microbiological and histopathological studies for confirming the clinical diagnosis. Rapid diagnosis, liposomal amphotericin B, and proper debridement of affected tissue are necessary to avoid a fatal outcome.
  4,906 196 5
LETTERS TO THE EDITOR
Cyclophosphamide-induced syndrome of inappropriate antidiuretic hormone secretion
Karthika Natarajan, CR Srinivas, K Jayachandran, R. M. P. L Ramanathan
November-December 2009, 75(6):629-630
DOI:10.4103/0378-6323.57739  PMID:19915258
  4,943 104 -
CASE REPORTS
Eccrine spiradenoma with chondroid syringoma in Blaschkoid distribution
Amiya Kumar Nath, Rashmi Kumari, Devinder Mohan Thappa
November-December 2009, 75(6):600-602
DOI:10.4103/0378-6323.57723  PMID:19915242
Eccrine spiradenoma (ES) very rarely presents in a linear or zosteriform distribution. It may be associated with foci of various other appendageal tumors. We report a 14-year-old boy who presented to us with multiple nodules in a linear distribution in the posterior aspect of the right lower limb since 2 years of age. The lesions became significantly painful for the past 2 years. Histopathology revealed dermal lobules of ES with smaller foci of chondroid syringoma.
  4,704 120 7
ORIGINAL ARTICLES
Comparative case control study of clinical features and human leukocyte antigen susceptibility between familial and nonfamilial vitiligo
Rachita Misri, Uday Khopkar, U Shankarkumar, K Ghosh
November-December 2009, 75(6):583-587
DOI:10.4103/0378-6323.57719  PMID:19915238
Background: Various studies worldwide suggest that human leukocyte antigen (HLA) region may be involved in the genetic susceptibility of vitiligo but little information is available from India. Aim: To find the HLA associated susceptibility to develop vitiligo in Indian patients and to detect role of HLA in familial vitiligo. Methods: This was a case controlled study which included all patients suffering from vitiligo over a period of one and half years. Clinical details were noted and sera collected from these patients were screened for the presence of HLA class I antibodies. The clinical features and HLA antigens were assessed and comparison was made between patients with familial and nonfamilial vitiligo. Results: Out of 114 patients studied, 84 had family history and 30 had no family history. Patients with family history of vitiligo have higher chances of acquiring vitiligo if first degree relatives are affected compared to if second degree relatives are affected. Family history of vitiligo is associated with an early onset of vitiligo (< 20 years). There was no statistically significant difference in the type, stability, and severity of vitiligo in both the groups. HLA results in both the groups revealed increase in HLA A2, A11, A31, A33, B17, B35, B40, and B44 alleles while HLA A9, B13, and B53 alleles were decreased. Family history was associated with HLA A2, A28, A31, and B44 alleles. Early onset of vitiligo (< 20 years) was significantly associated with HLA A2, A11, B17, B35, and B44 alleles. The patients with severe affection (> 10% area) showed in significant association with HLA A10 and B8. Conclusion: Family history of vitiligo is associated with an early onset of vitiligo. There is no correlation of family history with the type of vitiligo, stability of lesions, and areas involved. Severity is not associated with family history. Apart from other alleles, alleles A2, and B44 play a significant role in vitiligo in the Indian patients.
  4,587 179 5
CASE REPORTS
Dermatitis artefacta: Keloids and foreign body granuloma due to overvalued ideation of acupuncture
Sanjiv V Choudhary, Praveen Khairkar, Adarshlata Singh, Sumit Gupta
November-December 2009, 75(6):606-608
DOI:10.4103/0378-6323.57725  PMID:19915244
Skin is well recognized as an important somatic mirror of one's emotion and a site for the discharge of one's anxieties. We present a case of a 42-year-old female patient presenting with a vague history of generalized body pain and skin lesions in the form of cotton threads buried under the skin, crusted plaque, multiple keloids and rusted pin buried through the skin mostly in the easily accessible areas of the body. Histopathology from the crusted plaque revealed foreign body granuloma. To satisfy her psychological or emotional need, it is the deliberate and conscious production of self-inflicted skin lesions through overvalued ideation of acupuncture on her part.
  4,592 123 2
NET STUDY
Cutaneous lesions in Turkish neonates born in a teaching hospital
G Gokdemir, H Kaya Erdogan, A Koslu, B Baksu
November-December 2009, 75(6):638-638
DOI:10.4103/0378-6323.57742  PMID:19915262
Background: The neonatal period is regarded as the first 4 weeks of extrauterine life. In the literature, there are numerous articles about the skin findings in neonates and the results of these studies show differences according to races and environmental factors. Aýms: Our objective was to evaluate the skin lesions seen in neonates delivered in our hospital and to determine their relationship to gender, gestational age and route of delivery. Methods: Newborns delivered at the Obstetrics Clinics of our hospital between November 2007 and April 2008 were included in this study. Dermatologic examination was performed and relationship between the 10 most common skin findings and gender, gestational age and route of delivery were statistically evaluated. Results: A total of 572 newborns were examined for the presence of skin lesions. Most common skin findings were Epstein pearls (58.76%), sebaceous hyperlasia (48.45%) and xerosis (31.29%). Milia and sebaceous hyperplasia in girls, desquamation and xerosis in preterms, Epstein pearls, sebaceous hyperplasia and desquamation in vaginally delivered babies were found to be more frequent and the differences were statistically significant. Conclusýon: We found that 90.7% of the neonates had one or more cutaneous lesions. Maturity and type of delivery of the babies were important factors in their causation. In Turkey, this study is the first study performed on the skin lesions seen during the neonatal period. With this study, we want to increase the awareness about the skin findings in neonates.
  4,524 186 21
CASE REPORTS
Pemphigus vegetans in a patient with colonic cancer
Tiago Torres, Marcia Ferreira, Madalena Sanches, Manuela Selores
November-December 2009, 75(6):603-605
DOI:10.4103/0378-6323.57724  PMID:19915243
Pemphigus vegetans is a rare variant of pemphigus vulgaris characterized by vegetating plaques in the flexural regions. The coexistence of pemphigus vegetans and internal neoplasm is rare, being described only in four cases in the literature. We report the case of a patient with a typical skin eruption of pemphigus vegetans, who was detected with colonic cancer.
  4,014 120 5
LETTERS TO THE EDITOR
Trauma-induced bullous pemphigoid
Chrysovalantis Korfitis, Stamatis Gregoriou, Sofia Georgala, Eleftheria Christofidou, Iphigenia Danopoulou
November-December 2009, 75(6):617-619
DOI:10.4103/0378-6323.57732  PMID:19915251
  3,814 92 2
IMAGES IN CLINICAL PRACTICE
Norwegian scabies presenting as erythroderma
Vandana Mehta, C Balachandran, Puja Monga, Raghavendra Rao, Lakshmi Rao
November-December 2009, 75(6):609-610
DOI:10.4103/0378-6323.57726  PMID:19915245
  3,620 173 2
NET QUIZ
Nodule on the chest
Saurabh Agarwal, Binay Kumar, Naveen Sharma
November-December 2009, 75(6):639-639
DOI:10.4103/0378-6323.57746  PMID:19915263
  3,428 172 3
LETTERS TO THE EDITOR
Tzanck smear finding of Dorfman-Chanarin syndrome
Murat Durdu, Fahrettin Akay, Tevfik Alper, Serkan Yasar Celik
November-December 2009, 75(6):625-627
DOI:10.4103/0378-6323.57737  PMID:19915256
  3,497 99 1
Prevalence of genital Chlamydia infection in females attending an Obstetrics and Gynecology out patient department in Orissa
Bhagirathi Dwibedi, JM Pramanik, Prajyoti Sahu, Shantanu Kumar Kar, T Moharana
November-December 2009, 75(6):614-616
DOI:10.4103/0378-6323.57730  PMID:19915249
  3,397 144 2
Down's syndrome with lichen nitidus and segmental vitiligo
Saurabh Agarwal, Vishal Guglani, Binay Kumar
November-December 2009, 75(6):627-629
DOI:10.4103/0378-6323.57738  PMID:19915257
  3,275 127 3
Penicillium marneffei : The pathogen at our doorstep
Vasant Baradkar, Simit Kumar, SD Kulkarni
November-December 2009, 75(6):619-620
DOI:10.4103/0378-6323.57733  PMID:19915252
  3,093 115 -
NET LETTERS
Congenital giant tufted angioma
IS Reddy, S. V. N Anuradha, G Swarnalata
November-December 2009, 75(6):639-639
DOI:10.4103/0378-6323.57744  PMID:19915265
  3,099 103 3
LETTERS TO THE EDITOR
Opioid-mediated immunosuppression as a novel mechanism for the immunomodulatory effect of ultraviolet radiation
Mohammad Kazem Fallahzadeh, Mohammad Reza Namazi
November-December 2009, 75(6):622-623
DOI:10.4103/0378-6323.57735  PMID:19915254
  3,069 87 1
CURRENT BEST EVIDENCE
Current best evidence from dermatology literature
Parul Verma, Sujay Khandpur
November-December 2009, 75(6):640-643
  2,759 150 -
LETTERS TO THE EDITOR
Linear scleroderma with partial anonychia
Sanjay Singh, Surendra Kumar
November-December 2009, 75(6):623-625
DOI:10.4103/0378-6323.57736  PMID:19915255
  2,796 96 -
Stability of human immunodeficiency virus antibodies in filter paper-spotted serum
Ravindra R Kamble, Vidyagourie S Shinde, Severina P Madhale, Rupendra S Jadhav
November-December 2009, 75(6):616-617
DOI:10.4103/0378-6323.57731  PMID:19915250
  2,796 84 1
Leprosy control activities integration into the general health system, in the endemic area of South Gujarat region
Rajesh K Chudasama, Bharat C Solanki
November-December 2009, 75(6):611-613
DOI:10.4103/0378-6323.57728  PMID:19915246
  2,687 116 -
Enhancing digital images using unsharp-mask
Feroze Kaliyadan
November-December 2009, 75(6):611-611
DOI:10.4103/0378-6323.57727  PMID:19915247
  2,154 76 -
Online since 15th March '04
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