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   1999| July-August  | Volume 65 | Issue 4  
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Etiopathogenesis of vitiligo: are we dealing with an environmental disorder?
PN Behl, A Agarval, G Srivastava
July-August 1999, 65(4):161-167
The increasing incidence of vitiligo in this part of the world (4.25%), prompted us to study 5000 fresh vitiligo patients. Several triggering factors were elicitable. Malnutrition and intake of junk food were very common in childhood vitiligo. Intercurrent infections as well as intake of antibotics were also significant, immediately preceding the development of depigmented patches in younger age group. Genetic predisposition was uncommon. Autoimmune disorders were infrequent and usually accompanied late onset vitiligo. For management, vitiligo was classified into VI (active), V2 (quiescent) and V3 (improving) stages. The therapy administered varied in each stage. As a common denominator, all out efforts were made to eliminate possible trigger factors in individual cases throughout the period of treatment, and building the general health to prevent recurrence in future. The study strongly points out that vitiligo is a multifactorial disorder. It can be effectively managed after each patient is individually assessed. Elimination of possible triggering factors may form the mainstay of vitiligo therapy along with controlled pharmacological intervention. The improvement of general resistance of body may bring spontaneous repigmentation.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
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Prolong continuous versus weekly oral acyclovir in recurrent herpes genitalis
BL Masuria, MK Singhi, R Khullar, A Batra, RK Kothiwala, A Garg
July-August 1999, 65(4):174-176
Patients with frequent recurrences of genital herpes were treated with oral acyclovir tablet, 800 mg once daily or once a week for 2 years. Confirmed recurrences for all patients were treated with acyclovir. 200 mg orally 5 limes per day, for five days. Of 58 patients enrolled, 12 of 26 daily acyclovir recipients and 22 of 32 weekly acyclovir recipients completed two years of study. Patients receiving daily acyclovir experienced a mean of 0.0991 recurrences / month compared with mean of 0.113 recurrences / month for patients receiving weekly acyclovir. A total of 33% of daily acyclovir recipients and 27% weekly acyclovir recipients were free of recurrences for two years.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
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Angiolymphoid hyperplasia with eosinophilia (ALHE) versus kimura's disease: changing concepts
Veena Maheshwari, Rajeev Sharma, Kiran Alam, AH Khan
July-August 1999, 65(4):186-188
The clinico-pathological differences between Kimura’s angiolymphoid hyperplasia with eosinophilia are presented to emphasize that they are two separate disease entities which until now were considered as the same disease.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
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Bacteriological study of pyoderma with special reference to antibiotic susceptibility to newer antibiotics
DP Ghadage, YA Sali
July-August 1999, 65(4):177-181
Five hundred and forty-two cases of pyoderma were investigated to study bacterial aetiology and their antibiotic susceptibility patterns. Of these 65.87% cases were of primary pyoderma and the rest were of secondary pyoderma. Maximum cases were of impetigo (38.78%) followed by folliculitis (12.92%),furunculosis (2.95%), ecthyma (3.5%), carbuncle (1.5%) and sycosis barbae (0.4%). Secondary pyoderma constituted infected trophic ulcer (18.82%), infected pemphigus (7.2%), infected contact dermatitis (6.27%), and infected scabies (1.8%). Single organism was isolated from 46.9% cases end more than one type of organisms in 65.46% of cases. No organism was isolated in 5% of cases. Staphylococcus (67.34%) was the predominant species isolated followed by beta-haemolytic streptococcus (21.77%). Maximum strains of Staph, aureus were susceptible to amikacin (75%), co-trimoxazole (72%), cefotaxime (65%), chloramphenicol (62%), ciprofloxacin (61%) and clindamycin (61%). There was low susceptibility to cephaloridin (11%), gentamicin (12%) and penicillin (21%). Streptococcus betahaemolyticus was highly sensitive to most of the antibiotics and less sensitive to cefotaxime (7%), co-trimoxazole (11%) and penicillin (27%). Most of the strains were found to be resistant to one or more antibiotics.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
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A clinico - pathological study of 70 cases of pemphigus
SR Arya, AG Valand, K Krishna
July-August 1999, 65(4):168-171
A clinicopathological study of 70 cases of pemphigus observed over a span of four and a half years from January 1992 to June 1996 at the Sir J J. Group of Hospitals and Grant Medical College, Mumbai is reported. Pemphigus vulgaris constituted the single largest group of 43 cases, followed by pemphigus foliaceus (25 cases) and pemphigus vegetans (2 cases). Majority of the cases were seen in the age group of 21-60 years, with a slight male predominance. The youngest patient was 14 years while the eldest was aged 75 years. Mucosal involvement was seen in 31 cases of pemphigus vulgaris, as opposed to only 5 cases of pemphigus foliaceus. Flaccid bullae were present in 100% cases. Pruritus was complained of in 14 cases, though it was more common in pemphigus vegetans and vulgaris. Salient histopathological features of pemphigus vulgaris observed were (1) intraepidermal suprabasal blisters (35 cases), (2) presence of acantholytic cells (40 cases), (3) “ Row of tombstone appearance “(18 cases) and (4) acantholysis involving follicular sheath (20 cases). Main histopathological features of pemphigus foliaceus were (1) subcorneal blister (15 case), (2) acantholysis (24 cases) and (3) bulla cavity containing inflammatory infiltrate (12 cases). Both cases of pemphigus vegetans showed hyperkeratosis, papillomatosis and irregular acanthosis with intra-epidermal eosinophilic abscesses besides suprabasal lacunae.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
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Sexual behaviour and HIV prevalence in patients with sexually transmitted disease attending an STD clinic in north eastern state of india
PK Kar
July-August 1999, 65(4):182-185
The study was done to determine the sexual risk behaviour and to monitor HIV seroprevalence among STD patients attending a STD clinic as a part of sentinel surveillance programme in North Eastern State of India. Face to face interviews, clinical and epidemiological investigations were carried out in all new patients. The frequency of condom use, and the number of sexual partners during the preceding 6 months were recorded. Out of 680 males, majority (66.4%) were aged 20-29 years. 89.2% men reported to have had sexual contacts with prostitutes. Being younger, single and staying away from home were independent risk factors for having sexual contact. 34.7% men used condom at all times, 27.2% reported inconsistent use and 38.1% did not use condoms. Eleven (1.6%) of the 680 STD patients tested were found to be HIV positive, did not use condom and had genitoulcerative disease.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
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Congenital erythropoietic porphyria associated with ventricular septal defect
Parimalam Kumar, M Manimegalai, S Amudha, S Premalatha
July-August 1999, 65(4):189-190
A case of congenital erythropoietic porphyria associated with ventricular septal defect in a 6-year-old girl is reported.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
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Ichthyosis vulgaris involving the scalp area affected by androgenetic alopecia
Apra Sood, Pascal D'Souza, RK Pandhi
July-August 1999, 65(4):198-198
Full text not available  [PDF]  [PubMed]
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Pyoderma gangrenosum associated with ulcerative colitis - first case report from nepal
Manoj Sethi, Mary Jacob, Arun Agarwalla
July-August 1999, 65(4):193-195
A case of pyoderma gangrenosum with ulcerative colitis from Nepal is reported. The patient responded well to a combination of oral steroids, clofazimine, dapsone and salazopyrine within a period of 3 months.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
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A clinico - histopathological outcome of 4 weeks methotrexate pulse therapy in psoriasis
BL Masuria, NK Bansal, M Sharma, MK Singhi, A Mittal, LK Gupta
July-August 1999, 65(4):172-173
A clinico - histopathological study was carried out In 50 patients of psoriasis to see clinical and histological outcome and/or correlation of weekly methotrexate pulse therapy. Clinically, results of therapy were evalutated by estimating the percentage of total body coverage with psoriasis. Prior to therapy, average involvement was 47.5% which after 4 weeks methotrexate therapy reduced to 8.3%. A complete clearing of psoriasis occurred in 40% of patients after methotrexate therapy. The clinical response started as early as 1 week in most of patients. Only 2 patients failed to respond even after 4 weeks of therapy. Histopathologically in pretreatment biopsy, 34 showed classical psoriatic pathology while in 16 biopsy was suggestive of psoriasis but not confirmative. Histopathological examination after 4 weeks treatment showed that 41 still showed one or more histological evidence of psoriasis, although only two patients had classical, psoriatic pathology, in rest 9 patients there were complete regression. Thus, with methotrexate, clinical clearance was much faster than histopathological clearance.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
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Symmetrical progressive erythro-keratoderma
Gupta Sunil, Kataria Usha
July-August 1999, 65(4):191-192
A 13-year-old male child had gradually progressive, bilaterall, symmetrical, erythematous hyperkeratotic plaques over knees, elbows, natal cleft, dorsa of hands and feet with palmoplantar keratoderma. High arched palate, fissured tongue and sternal depression (pectus-excavatum) were unusual associations.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
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Nail changes secondary to systemic drugs
Radha Rani Mittal, Jastinder Kullar
July-August 1999, 65(4):196-197
Full text not available  [PDF]  [PubMed]
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Foot wear dermatitis
CR Srinivas, Anurag Tiwari
July-August 1999, 65(4):197-198
Full text not available  [PDF]  [PubMed]
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Post kala azar dermal leishmaniasis
V Ramesh
July-August 1999, 65(4):196-196
Full text not available  [PDF]
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Abstracts from current literature

July-August 1999, 65(4):199-201
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July-August 1999, 65(4):202-202
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