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  Citation statistics : Table of Contents
   1990| May-June  | Volume 56 | Issue 3  
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Indigenous cutaneous leishmaniasis
K Muhammed, K Narayani, KP Aravindan
May-June 1990, 56(3):228-229
A 20 year old male from Nilambur of Malappuram district of Kerala developed an asymptomatic , single, well circumscribed erythomatous indurated plaque about 3x 2.5 cm in size with central crusting, on the left forearm just about the wrist on the lateral aspect, of six months duration. He had never gone out of his native place at any time in his life, Slit smear examination and staining with Giemsa stain showed plenty of extracelluar and intracellular Leishman, Donovan bodies, ,Histopathology of the lesion was consistent with diagnosis of cutaneous Leishmaniasis. He was treated with rifampicin'600 mg and the lesion showed signs of regression within one month.
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Elucidation and management of 30 patients of drug induced toxic epidermal necrolysis (DTEN)
Surrinder Kaur, Arti Nanda, K Vinod Sharma
May-June 1990, 56(3):196-199
Thirty patients of drug induced toxic epidermal necrolysis (DTEN) were seen over a period of 7 years. They included 16 males and 14 females and their ages ranged from 5 months to 60 years with a mean of 23 years. The epidermal necrosis affected 20-100% of the body surface area. The oral, nasal and conjunctival mucosae were involved in all the cases. Antitubercular drugs were the most common offending agents (1/3rd of the patients) followed by anticonvuIsants, sulfonamides, butazones, and antibiotics. TEN proved fatal in 8 (27%) patients with septicemia being the most common predisposing factor. Other factors which contributed to fatal outcome were underlying severe disease in 2 patients and disseminated intravascular coagulation in one.
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Therapeutic efifect of doxepin in chronic idiopathic urticaria
S Ghose, S Haldar
May-June 1990, 56(3):218-220
Among 56 recalcitrant cases of chronic idiopathic urticaria 28 subjects (Group A) selected at random, were, treated with doxepin 10 mg thrice daily and the rest ( Group B ) with pheniramine maleate 22.5mgthrice daily.B 3 weeks of therapy group.A and group B respectively showed complete remission in 28.6% and 10.7% cases, partial remission in 64.3% and 39.3% cases and no improvement in 7.1% and 50% cases. The difference in clinical improvement between the two groups was statistii significant (p0.001). One week after stopping the treatment among totally syrnptom - free patients, 37.5% in group A and 100% in-group B developed recurrence. Drowsiness was more common in-group B (60.7%) than in group A (35.7%) whereas dryness of the mouth was more frequent in group A (64.3%) than in group B (46.4%).
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Efficacy of cotrimoxazole and PUVA for the management of chronic folliculitus of legs
Kalpana Shenoy, CR Srinivas, Savitri Sharma, PG Shivananda, JN Shetty
May-June 1990, 56(3):223-225
Twenty five patients with chronic follicufitis of legs (CFL) were treated with cotimoxazole and 8-methoxypsoralen followed by exposure to sunlight for 15 minutes. In another 20 patients taken as control 8-MOP was substituted with a placebo. After 45 days 19 (90.5%) patients in the study group as compared-to 11 (55%) in the control group were free of lesions (p). At the end of 3 months 10 (62.5%) out of 16 patients in the study group as compared to 3 (30%) out of 10 patients in the control group showed improvement which was statistically not significant (p ). Coagulase positive Staphylococcus aureus was isolated from the pus in all the 45 cases. In vitro experiments were carried out by mixing the Staphylococcus with a solution of 50 micro -gm/ml of 8 MOP, 1200 micro -gm/ml cotrimoxazole and 50 micro-gm/ml8-MOP mixture, 1200 micro -gm/ml of cotrimoxazole and saline. A part of each of the samples was exposed to sunlight for 15 minutes between 3 pm and 3.15 pm and then streaked on blood agar medium Remaining part was streaked without sun exposure. Inhibition of growth was observed with photoactivated 8 - MOP, cotrimoxazole and 8-MOP mixture and cotrimoxazole, both with and without exposure to sunlight. Sunlight alone did not inhibit the growth.
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Anthrlin short contact therapy in psoriasis
PK Kar, PK Jha, PS Snehi
May-June 1990, 56(3):193-195
Forty cases of psoriasis were treated with dithranol daily for 20 minutes as short contact therapy. The results were compared with another 20 psoriasis patients using dithranol paste as per Ingram technique. Short contact therapy resulted in complete regression in 24 (60%) patients, 90% regression of lesions in 5 (12.5%) patients and deterioration in 2 (5%) cases. The average rate of clearance of lesions was between 10-30 days. Psoriatic lesions disappeared without leaving spotty hyperpigmentation. Dithranol paste as used in the Ingram technique showed complete clearing in 11 (55%) patients, 90% clearing in 5 (25%) cases and deterioration in 4 (20%) patients. Ninety percent cases developed spotty hyperpigmentation and 50% patients experienced marked to fiery red erythema during the course of treatment. Short contact therapy gave minimal side effects and good cosmetic results.
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Malignant change in lupus vulgaris
M Girdhar, M Gupta, SK Arora, L Mohan, RD Mukhija
May-June 1990, 56(3):226-227
Two cases developed squamous cell carcinoma over the lupus vulgaris lesions. The first patient was a, 14 year male with a gradually developing painless, hypertrophic lesion just below the left knee for 6 years. Four years later a cauliflower growth developed over it. He was on antitubercular therapy for 3 months without any improvement. The second patient was 42 year male with a painless, growing lesion behind the right knee for 25 years. About 9 months back a rapidly progressive painful ulcerated mass developed over it which used to bleed easily o n slight trauma. Histopathological findings in both the cases were compatible with lupus vulgaris and squamous cell carcinoma. None of the cases had recurrence following excision and subsequent antitubercular therapy.
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Candidial esophagitis - A marker for HIV infection
B Kumar, M Rajagopalan, S Sehgal
May-June 1990, 56(3):230-231
A case of AIDS manifested as candidial esophagitis. In addition , he had genital herpes, frequent diarrhoea, loss of weight and generalized lymphadenopathy. The diagnosis was confirmed by endoscopy. The patient died in 3 months due to unremitting diarrhoea. This importance of candidial esophagitis in a person at risk for developing AIDS is highlighted.
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Epithelioma cuniculatum
Sehgal Uttera
May-June 1990, 56(3):232-233
A 60 year old male had a slow growing verucous growth on his left sole for the last 20 years. This histopathological examination revealed features consistent with verrucous carcinoma of the foot.
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Pemphigus foliaceous induced by penicillamine
K Kaushal Verma, JS Pasricha
May-June 1990, 56(3):234-235
A 44 year old man having rhcumatoid arthritis developed pemphigus foliaccous after 7 months of taking 500: mg D-penicillamine a day. The lesions regressed on stopping the drug and reappeared whet the drug was started again. Skin biopsy revealed a subcorneal split suggestive of pemphigus foliaceous. Direct immunofluorescent staining of the skin biopsy for IgG revealed an intercellular pattern and the indirect immunofluorescent on the patient's serum revealed a titre of 1 : 10. The lesions disappeared within 2 weeks of discontinuation of the drug.
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Topical minoxidil in androgenetic alopecia, how good is it ?
Raj Kubba
May-June 1990, 56(3):187-192
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Eye changes in psoriatic arthropathy
SP Chaudhari Ray, Inderjeet Kaur, Jagat Ram, Surrinder Kaur
May-June 1990, 56(3):221-222
Forty patients of psoriatic arthitis were examined for eye changes. Other than blepharitis seen in 2 patients and seitile cataract in 3 patients no eye changes could be elicited. Out of the, 18 patients HLA-B 27 was in 3 patients whereas Al and B 17 was in 6 and 9 patients respectively.
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Clinical profile of psoriatic arthropathy
SP Chaudhary Ray, Trilochan Singh, Inderjeet Kaur, Sudha Suri, Shobha Sehgal, Surrinder Kaur
May-June 1990, 56(3):200-203
Thirty patients of psoriatic arthritis were examined for, elucidation of Epidemiological aspects and clinical variation of this disease. Mill's and Wright criteria for the diagnosis of was applied. Arthritis antedated psoriasis of skin in 13.3% and the onset was acute in .36.7%. The types of arthritis observed were polyarticular in 33.3% mixed in 2D%, oligoarthritis in 16.7%, DIP in 13.3%, sacroilitis 'in 10% and arthritis mutilans in 6.7%. The joints found to be most frequently involved were proximal 'interphalangeal (66.6%) and distal interphalangeal joints (65%) of I the hands. No distinct pattern of dermal psoriasis in psoriatic arthritis was observed., Nail changes were observed in 76.60/c of patients. No other eye changes except blepharitis was seen in two (7%) patients.HLA-A and HLA-B phenotyping was done in 16 patients, among them 12 patients had peripheral type of psoriatic arthritis HIA-A 1 B 17 and B 27 were present in 6 (20%),9 (30%) and 2 (7%) patients respectively.
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An open comparlson of mupirocln and oxyteracycline for the therapy of skin infections
Vinay Kulkarni, MB Gharpuray, SS Nene
May-June 1990, 56(3):204-207
Mupirocin (pseudomonic acid) is a new antibacterial compound active against a wide range of organisms responsible for skin and soft tissue infections. It is bactericidal at concentrations achieved following topical application. An open comparative study was carried out to assess the clinical and bacteriological effectiveness of 2% muhirocin as compared to 3% oxytertracycline by topical application in a variety of primary and secondary skin infections. Fifty patients were included in each age and sex matched group. The overall efficacy of mupirocin was 92% compared to 80% of oxytetracycline. Mupirocin was especially effective in cases of impetigo, 75% cases being cured and 25% showing good improvement at the end of 12 days. With oxytetracycline the figures were 40% cured and 33.3% showing good response. The speed of recovery with mupirocin was faster than with oxytetracycline.
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Cerebro-spinal fluid examination in early syphilis after treatment with penicillin
S Talwar, MA Tutakne
May-June 1990, 56(3):208-210
In case s having early syphilis, cerebro-spinal fluid:(CSF) was examined 6 months following pencillin treatment in 1173 cases of which 1 case showed some abnormality. In 1288 cases, CSF examination done at 30 months or later revealed abnormality in 3 cases. The initial diagnosis in these cases was primary syphilis in 2 cases and secondary syphilis in the remaining 2 and these cases had initially been treated with 2.4 MU of benzathine penicillin. These 4 cases were now diagnosed as cases of asymptomatic nourosyphifis and retreated with 9 MU Of procaine penicillin. AU these cases were cured following retreatment. Considering this small number (0.17%), it is considered unessential to examine CSF as a routine in early -syphilis.' However in cases where the clinical or serological response to treatment is not satisfactory, CSF examination is advisable.
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Porokeratosis of mibelli
AS Prasad, Gurmohan Singh
May-June 1990, 56(3):211-212
Twenty two cases of porokeratosis of Mibelli belonging to two separate families having 18 and 4 cases respectively were studied. Their pedigress traced in three generations followed an autosomal dominant pattern.
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Age of onset of leprosy
K Pramod Nigam, Uttera Sehgal, V Ramesh, RS Misra
May-June 1990, 56(3):213-215
The age of onset of leprosy was studied in 1012 consecutive patients. Although no age was exempt, majority of the patients had onset of their disease during the 10-29 years of age. There was no significant difference in the mean age pf onset of leprosy among males and females. The paucibacillary group had significantly lower age of onset as compared to multibacillary cases. The comparison of other studies on age of onset from India and elsewhere showed that this varies in different regions within the country, on different times at the same place, as well as from country to country.
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