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2005| July-August | Volume 71 | Issue 4
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STUDIES
Pityriasis versicolor in the pediatric age group
Deepak Kumar Jena, Sujata Sengupta, Binayak Chandra Dwari, Manoj Kumar Ram
July-August 2005, 71(4):259-261
DOI
:10.4103/0378-6323.16618
PMID
:16394435
BACKGROUND:
Pityriasis versicolor (PV) is a mild chronic infection of the skin caused by Malassezia yeasts. Although it is primarily seen in adults, children are often affected in the tropics
. METHODS:
Over a period of 2 years, children (up to the age of 14 years) who were clinically and mycologically diagnosed as PV were included in the study. The clinical and epidemiological pattern in different age groups was noted.
RESULTS:
PV in this age group formed about 31% of the total cases of PV; 4.8% cases presented in infancy. The commonest site of involvement was the face in 39.9% of the cases. Most of the cases presented in summer months.
CONCLUSIONS:
PV is not an uncommon disease among children in the tropics. There is a sudden resurgence of cases in the hot monsoons and even infants are not spared.
[ABSTRACT]
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9,551
421
Correlation of the severity of atopic dermatitis with absolute eosinophil counts in peripheral blood and serum IgE levels
Sandipan Dhar, Rajib Malakar, Soumen Chattopadhyay, Subhra Dhar, Raghubir Banerjee, Apurba Ghosh
July-August 2005, 71(4):246-249
DOI
:10.4103/0378-6323.16615
PMID
:16394432
BACKGROUND:
Although a number of epidemiological studies, showing incidence and prevalence of atopic dermatitis, were available, scant attention has been paid to the correlation between the parameters of the disease like severity, absolute eosinophil count and IgE level, which has been known to be associated inconsistently. Hence this study was undertaken.
METHODS:
A total of 102 patients of atopic dermatitis, both children and adults, and 107 age matched controls were studied at the Pediatric Dermatology clinic, Institute of Child Health and department of Dermatology, AMRI-Apollo hospitals, Kolkata.
RESULTS:
The average age of onset of atopic dermatitis was observed to be 4.55 years. Both the average absolute eosinophil count and IgE levels in patients of atopic dermatitis were significantly higher than that of the controls. Each of these parameters showed significant correlation with severity of the disease and showed a nonhomogeneous distribution reflected by significant association with personal history of bronchial asthma and family history of atopy, when both parents were atopic.
CONCLUSIONS:
Our study shows that clinical activity of the disease as recorded by the "SCORAD" index can be used as an indicator of the hematological abnormalities as well as to some extent as a prognostic indicator. Family history of atopy correlates with the hematological abnormalities only if both parents are involved and bronchial asthma is the only associated atopic condition which correlates with the parameters of the disease
.
[ABSTRACT]
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13,065
410
LETTER TO EDITOR
Lichenoid eruption due to imatinib
K Prabhash, DC Doval
July-August 2005, 71(4):287-288
DOI
:10.4103/0378-6323.16627
PMID
:16394444
[FULL TEXT]
[PDF]
[CITATIONS]
[PubMed]
17
4,863
143
Imatinib induced Stevens-Johnson syndrome: Lack of recurrence following re-challenge with a lower dose
Keechilat Pavithran, Mathew Thomas
July-August 2005, 71(4):288-289
DOI
:10.4103/0378-6323.16628
PMID
:16394445
[FULL TEXT]
[PDF]
[CITATIONS]
[PubMed]
17
5,693
187
RESIDENT’S PAGE
Tzanck smear: A useful diagnostic tool
Lalit Kumar Gupta, MK Singhi
July-August 2005, 71(4):295-299
DOI
:10.4103/0378-6323.16632
PMID
:16394449
[FULL TEXT]
[PDF]
[CITATIONS]
[PubMed]
17
106,893
4,294
STUDIES
An open randomized comparative study of oral itraconazole pulse and terbinafine pulse in the treatment of onychomycosis
Minati Mishra, P Panda, Satyabrata Tripathy, Sujata Sengupta, Kaushik Mishra
July-August 2005, 71(4):262-266
DOI
:10.4103/0378-6323.16619
PMID
:16394436
BACKGROUND:
Onychomycosis is a recalcitrant disease of the nails caused by dermatophytes, yeasts, and molds.
AIMS:
To compare the clinical efficacy of oral itraconazole pulse therapy and oral terbinafine pulse therapy in onychomycosis.
METHODS:
A randomized single-blind clinical comparative study was undertaken on 120 patients of onychomycosis during the period March 1999-February 2002. Sixty patients were randomly assigned to receive oral itraconazole 100 mg, two capsules twice daily for seven days a month and the other group of sixty patients received oral terbinafine 250 mg, one tablet twice daily for seven days every month. Four such monthly pulses were administered for each drug. The patients were evaluated at 4-weekly intervals till sixteen weeks and then at 24, 36 and 48 weeks.
RESULTS:
We observed a clinical cure rate of 82% and mycological cure rate of 90% in the group of patients treated with itraconazole while the group with terbinafine showed clinical and mycological cure rates of 79% and 87% respectively. This difference was not statistically significant.
CONCLUSIONS:
Both oral itraconazole and terbinafine are effective in the treatment of onychomycosis when administered in the pulse dosage form. Terbinafine is more cost effective while itraconazole has a broader spectrum of antimycotic activity.
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CASE REPORTS
Presence of Mycobacterium leprae in epidermal cells of lepromatous skin and its significance
Jasmita Satapathy, Bikash Ranjan Kar, CK Job
July-August 2005, 71(4):267-269
DOI
:10.4103/0378-6323.16620
PMID
:16394437
A 49-year-old man with lepromatous leprosy treated with dapsone monotherapy for 12 years (1967 to 1979) reported in the hospital in 2003, with relapsed disease. A slit skin smear showed a bacteriological index of 4+. Biopsies from skin lesions before and after anti-leprosy therapy showed features of lepromatous leprosy. Both biopsies showed unusual features of bacillary clumps in epidermal cells demonstrating clearly that dissemination of
M. leprae
can take place even through unbroken skin. The presence of lepra bacilli in clumps in the epidermis is an indicator that the skin is a potential route of transmission of the disease.
[ABSTRACT]
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14
7,000
239
Focal dermal hypoplasia (Goltz syndrome)
Najeeba Riyaz, A Riyaz, Rajesh Chandran, SV Rakesh
July-August 2005, 71(4):279-281
DOI
:10.4103/0378-6323.16624
PMID
:16394441
A 7-year-old girl born of non-consanguineous marriage was evaluated for facial dysmorphism. She had multiple skeletal anomalies like hypoplasia of the right mandible, narrow nasal bridge with broad tip and unilateral notching of the right ala nasi, concomitant squint and low set ears. She also had generalized hypopigmented, atrophic linear macules, multiple papillomas, fat herniations, umbilical hernia, hypoplastic nails, cicatricial alopecia, mild mental retardation, 'lobster-claw' hand and osteopathia striata of long bones, pointing to a diagnosis of Goltz syndrome. The unusual features noted were absence of the left first rib and aortic regurgitation.
[ABSTRACT]
[FULL TEXT]
[PDF]
[CITATIONS]
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11,013
384
STUDIES
Dermatoses among paddy field workers - A descriptive, cross-sectional pilot study
Shrutakirthi D Shenoi, Suraj V Davis, Sugandhi Rao, Girija Rao, Sreekumaran Nair
July-August 2005, 71(4):254-258
DOI
:10.4103/0378-6323.16617
PMID
:16394434
BACKGROUND:
Paddy farming is one of the main occupations in coastal South India. Dermatological problems in paddy field workers have not received much attention.
AIM
: The purpose of this study was to study the dermatoses of the exposed parts of the body, viz. face, hands, and feet, in paddy field workers.
METHODS:
Three hundred and forty-one workers were questioned and clinical findings noted. Scrapings for bacterial and fungal examination were taken by random selection.
RESULTS:
Seventy-three per cent had work-related itching. Melasma was the commonest facial lesion (41.1%). The main problems on the hands were hyperkeratosis (26.4%), nail dystrophy (15.2%) and paronychia (8.8%). Common feet dermatoses included nail dystrophy (57.1%), pitted keratolysis (42.5%) and fissuring (23.5%). Common aerobic and anaerobic bacteria isolated from pitted keratolysis and intertrigo were
Klebsiella
and
Clostridium
species.
Aspergillus
species were the commonest fungus grown from intertrigo.
CONCLUSIONS:
Occupational dermatoses are common in paddy field workers.
[ABSTRACT]
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11,523
235
REVIEW ARTICLES
Iontophoresis in dermatology
Reena Rai, CR Srinivas
July-August 2005, 71(4):236-241
DOI
:10.4103/0378-6323.16613
PMID
:16394430
Iontophoresis is the process of increasing the penetration of drugs into the skin by application of an electric current. The drug is applied under an electrode of the same charge as the drug, and a return electrode opposite in charge to the drug is placed at a neutral site on the body surface. Electrical energy assists the movement of ions across the skin using the principle "like charges repel each other and opposite charges attract". In this article, we discuss the mechanism, principles, factors influencing iontophoresis and its application for various dermatological conditions.
[ABSTRACT]
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[CITATIONS]
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11
27,310
1,632
STUDIES
Post-kala-azar dermal leishmaniasis: A histopathological study
Sanjay K Rathi, RK Pandhi, P Chopra, N Khanna
July-August 2005, 71(4):250-253
DOI
:10.4103/0378-6323.16616
PMID
:16394433
BACKGROUND
: Post-kala-azar dermal leishmaniasis follows an attack of visceral leishmaniasis and is caused by the same organism,
i.e.
Leishmania donovani.
METHODS: In the present study, biopsy specimens from hypopigmented macules, nodules or plaques of 25 patients clinically diagnosed as PKDL were evaluated for epidermal and dermal changes and for the presence or absence of
Leishmania donovani
bodies (LDBs).
RESULTS
: The hypopigmented macules showed a patchy perivascular and periappendageal infiltrate with no demonstrable LDBs in any of the biopsies. In the nodular and plaque lesions, the infiltrate was diffuse, beneath an atrophic epidermis (74%) and follicular plugging (95.6%) was seen in most biopsies. The infiltrate consisted of lymphocytes, histiocytes and plasma cells in decreasing order of presence. LDBs could be demonstrated in only 10 (43.5%) biopsy specimens from nodular and plaque lesions and were never numerous.
CONCLUSIONS:
Histopathological features of PKDL are elucidated and discussed.
[ABSTRACT]
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9,596
285
CASE REPORTS
Pityriasis rosea-like eruptions due to mustard oil application
Vijay Zawar
July-August 2005, 71(4):282-284
DOI
:10.4103/0378-6323.16625
PMID
:16394442
A young man employed in a construction company, presented with cutaneous lesions clinically simulating pityriasis rosea. Satisfactory and complete response to corticosteroids and antihistamines was followed by recurrence. Multiple recurrences within a short span of time arose a suspicion of alternative diagnosis. Site visit helped us to rule out occupational contact dermatitis. Further history taking revealed that he was recently using mustard oil for body massage. Subsequent patch testing confirmed contact hypersensitivity to mustard oil. Avoidance of the contact with mustard oil arrested appearance of further skin lesions. We stress the importance of taking a good history in clinical practice in disclosing a possible contactant.
[ABSTRACT]
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[PubMed]
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9,561
165
SAPHO syndrome treated with pamidronate
Rustom Tehrani
July-August 2005, 71(4):273-275
DOI
:10.4103/0378-6323.16622
PMID
:16394439
A middle aged man presented with a 4 year history of painful swelling of both knees and pustular acne on his back. The MRI scan of the knees showed gross synovitis, so did the histopathology of the synovium. A diagnosis of SAPHO syndrome was made and he was treated with IV pamidronate. His pain reduced and acne completely cleared up on therapy. A dermatologist has rarely made a diagnosis of SAPHO syndrome and treated it.
[ABSTRACT]
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[PubMed]
9
8,983
274
VIEW POINT
'Final push of leprosy' in India: What is being pushed?
P Narasimha Rao, T S S Lakshmi
July-August 2005, 71(4):226-229
DOI
:10.4103/0378-6323.16611
PMID
:16394428
[FULL TEXT]
[PDF]
[CITATIONS]
[PubMed]
9
9,481
478
LETTER TO EDITOR
Pigmentary demarcation lines in pregnancy
Lalit Kumar Gupta, CM Kuldeep, Asit Mittal, Vijay Paliwal, Himanshu Singhal, Kalpana Agarwal, Jaya Tantia
July-August 2005, 71(4):292-293
DOI
:10.4103/0378-6323.16630
PMID
:16394447
[FULL TEXT]
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[PubMed]
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EDITORIAL
Skin to skin transmission of leprosy
BK Girdhar
July-August 2005, 71(4):223-225
DOI
:10.4103/0378-6323.16610
PMID
:16394427
[FULL TEXT]
[PDF]
[CITATIONS]
[PubMed]
6
13,561
300
LETTER TO EDITOR
Tumoral calcinosis
Chhanda Datta, Debabrata Bandyopadhyay, Swagata Bhattacharyya, Sulekha Ghosh
July-August 2005, 71(4):293-294
DOI
:10.4103/0378-6323.16631
PMID
:16394448
[FULL TEXT]
[PDF]
[CITATIONS]
[PubMed]
6
8,481
157
STUDIES
MDT-MB therapy in paucibacillary leprosy: A clinicopathological assessment
P V S Prasad, A Babu, PK Kaviarasan, P Viswanathan, Rehana Tippoo
July-August 2005, 71(4):242-245
DOI
:10.4103/0378-6323.16614
PMID
:16394431
BACKGROUND:
The World Health Organization recommends treatment regimens for paucibacillary (PB) and multibacillary (MB) leprosy, which differ in their duration and components. Hence accurate classification of the disease is required. To overcome difficulties in classification Uniform Multi Drug Therapy (U-MDT) has been recommended.
AIM
: To evaluate the benefit of adding clofazimine to paucibacillary regimens in leprosy patients by measuring clinical and histological resolution.
METHODS:
Forty-four paucibacillary patients were included in the study. Twenty-two patients were given MDT-PB regimen and the remaining MDT-MB regimen for six months
.
Skin biopsies were done before the commencement and at the end of treatment. Clinical and histological resolutions were measured according to the standard criteria a laid down. The results were analyzed using Fishers' test and Crammers' V test.
RESULTS:
Clinical improvement was observed in 90.9% in the MB group as compared to 27.3% in the PB group. Regression in the nerve swelling was observed in 70% in the MB group and in 37.5% in the PB group while histological resolution was observed in 72.8% and 54.5% respectively.
CONCLUSIONS:
Addition of clofazimine helps to resolve leprosy lesions both clinically and histologically, thus justifying the concept of Uniform MDT regimen for all patients.
[ABSTRACT]
[FULL TEXT]
[PDF]
[CITATIONS]
[PubMed]
4
8,707
274
CASE REPORTS
Behηet's disease with HIV infection: Response to antiretroviral therapy
Vikram K Mahajan, Nand Lal Sharma, Vikas C Sharma, Ramesh Chander Sharma, Sandip Sarin
July-August 2005, 71(4):276-278
DOI
:10.4103/0378-6323.16623
PMID
:16394440
The differential diagnosis of oral ulcerations in a patient with AIDS/HIV infection is often challenging to the clinician. While old diseases have appeared in a new garb, many new ones are also being recognized. The association of Behηet's disease and AIDS/HIV infection has been recently recognized. We present an HIV-positive patient having oro-genital aphthosis conforming to the diagnostic criteria for Behηet's disease. Erythema nodosum, periphlebitis, erythematous papulopustular lesions, half and half nails, ocular congestion, raised ESR and dimorphic anemia were some other features present. He had low CD4+/CD8+ counts. He had no other HIV-related disease. He responded well to triple anti-retroviral treatment alone. The possible pathomechanism of the occurrence of both diseases is also discussed.
[ABSTRACT]
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[CITATIONS]
[PubMed]
3
5,972
151
Reiter's disease in a six-year-old girl
Sandeep Arora, Gulhima Arora
July-August 2005, 71(4):285-286
DOI
:10.4103/0378-6323.16626
PMID
:16394443
Reiter's syndrome has characteristically been described in young males and presents with a triad of urethritis, conjunctivitis and arthritis. Reiter's syndrome has been known to affect children, although they usually do not manifest with the typical triad. Only a few such cases have been reported and these have described males predominantly. A case of a six-year-old girl who presented with watery diarrhea, redness of eyes and joint pains followed by skin involvement is reported. She was managed with topical salicylic acid and hydrocortisone, and oral aspirin and showed complete resolution of her clinical features in three weeks.
[ABSTRACT]
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3
8,285
196
Simultaneous occurrence of toxic epidermal necrolysis and neuroleptic malignant syndrome
K Muhammed, P Raman
July-August 2005, 71(4):270-272
DOI
:10.4103/0378-6323.16621
PMID
:16394438
Toxic epidermal necrolysis (TEN) is an acute life-threatening blistering disease characterized by involvement of the skin, multiple mucous membranes and internal organs. It is most commonly precipitated by the administration of medications like anticonvulsants. Neuroleptic malignant syndrome (NMS) is a rare complication of neuroleptic therapy characterized by catatonic behavior, generalized muscular rigidity, hyperthermia and autonomic dysfunction. An 18-year-old girl presenting with simultaneous appearance of TEN and NMS following anti-psychotic drugs given for bipolar mood disorder, is reported for the rare association and her complete recovery.
[ABSTRACT]
[FULL TEXT]
[PDF]
[CITATIONS]
[PubMed]
3
5,577
127
FOCUS
Dermoscope
KC Nischal, Uday Khopkar
July-August 2005, 71(4):300-303
DOI
:10.4103/0378-6323.16633
PMID
:16394450
[FULL TEXT]
[PDF]
[CITATIONS]
[PubMed]
2
19,451
1,415
REVIEW ARTICLES
Cryptic exposure to arsenic
Kathleen M Rossy, Christopher A Janusz, Robert A Schwartz
July-August 2005, 71(4):230-235
DOI
:10.4103/0378-6323.16612
PMID
:16394429
Arsenic is an odorless, colorless and tasteless element long linked with effects on the skin and viscera. Exposure to it may be cryptic. Although human intake can occur from four forms, elemental, inorganic (trivalent and pentavalent arsenic) and organic arsenic, the trivalent inorganic arsenicals constitute the major human hazard. Arsenic usually reaches the skin from occupational, therapeutic, or environmental exposure, although it still may be employed as a poison. Occupations involving new technologies are not exempt from arsenic exposure. Its acute and chronic effects are noteworthy. Treatment options exist for arsenic-induced pathology, but prevention of toxicity remains the main focus. Vitamin and mineral supplementation may play a role in the treatment of arsenic toxicity.
[ABSTRACT]
[FULL TEXT]
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[CITATIONS]
[PubMed]
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12,605
368
QUIZ
Subcutaneous cystic swelling in a leprosy patient
Bikash Ranjan Kar, G Ebenezer, CK Job
July-August 2005, 71(4):305-306
DOI
:10.4103/0378-6323.16635
PMID
:16394451
[FULL TEXT]
[PDF]
[CITATIONS]
[PubMed]
1
4,472
120
BOOK REVIEW
Textbook of Dermatosurgery and Cosmetology
Satish S Savant
July-August 2005, 71(4):304-304
[FULL TEXT]
[PDF]
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13,424
322
LETTER TO EDITOR
Role of language in dermatologist-patient relationship: "He who speaks well, treats well!"
Garehatty Rudrappa Kanthraj
July-August 2005, 71(4):290-291
DOI
:10.4103/0378-6323.16629
PMID
:16394446
[FULL TEXT]
[PDF]
[PubMed]
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5,254
128
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