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A 45-year-old man with acral lentiginous melanoma (AJCC Stage IV) of the left sole and lymph node metastasis is described. Three cycles of palliative combination chemotherapy administered to him resulted in the decrease of inguinal lump, however, the lesion over sole showed no variation.

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Background: Granuloma pyogenicum (GP) is a common vascular lesion which often bleeds easily during most of the treatment modalities. A number of pyogenic granulomas often recur after such treatment. Objective: The aim of this study was to establish a surgical procedure which is easy to operate, less invasive, minimal bleeding at the operation site and without any recurrence of the lesion. Methods: Twenty-three patients (15males, and 8females) suffering from granuloma pyogenicum at different stages (ulcerated, reepithelialized and resolving) and at various sites of the body constituted the sample population. In all the patients, crushing of the base of the lesions followed by shave excision and electrodesiccation of the shaved base were carried out. The patients were followed up for six months to observe recurrence, scar formation and any other complications. Results: Bleeding was practically nil during the surgical procedure in all the cases. There was no recurrence and cosmetic outcome was excellent. No complications were encountered. Conclusion: The technique is not only an alternative modality but can also be the treatment of choice in all stages of granuloma pyogenicum

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Ten Patients, 6 males and 4 females between 7-60 years of age having lichen planus for I month to 2 years were treated with betamethasone 5mg orally on two consecutive days in a week for 3 months. There was excellent (75-100%) response in 6 (60%) patients and good (50-75%) in 4 (40%) patients. None of the patients had significant side effects of the therapy and there were no treat­ment failures. Betamethasone on two consecutive days in a week as oral mini pulse therapy may be a safe, effective and a better therapeutic alternative for the treatment of lichen planus.

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Mucocutaneous lymph node syndrome has been rarely seen or reported in India because of its rare occurrence and probably because of its close resemblance to many exanthematous conditions. It is a characteristic disease with a unique clinical presentation. Knowledge about this established disease is essential as it can involve the coronary and other medium and small sized arteries causing vasculitis in about 20% of cases. This probably accounts for a significant number of ischemic heart diseases and sudden deaths in the young, i.e. in the second and third decades, later in life for which no other cause is found then. It is a condition diagnosed entirely on clinical basis and hence the need to be aware of its characteristic features.

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A 49-year -old woman presenting with features of cutaneous sarcoidosis without any evidence of systemic involvement is reported.

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One hundred, untreated, smear positive BB, BL and LL patients were treated with a regimen comprising of once a month, supervised, 600 mg of Rifampicin+ 400 mg Ofloxacin + 100 mg of Minocycline in addition to self administered 100 mg dapsone and 50 mg of clofazimine daily for twelve months.The treatment was then stopped and patients were followed up on placebo. This study reports the preliminary results after 2.5 to 3.5 years of post treatment follow-up. The drugs were well tolerated, the clinical response to the treatment was very good, and there was no case of treatment failure. Bacteriologically 25 out of the total 70 patients available for follow- up were still positive at the end of one year of treatment. These patients continued to progress satisfactorily and four patients were still positive at the end of 2 years. No growth was observed in the normal mouse foot pad after one year of therapy. No bacillary ATP was detected in the biopsy tissues after one year. While no M. leprae specific rRNA was detectable in any of the specimens after one year of treatment, weak PCR signals were detectable in 3/57 specimens at that period. In the follow up available no patient has relapsed. The patients are being followed up on placebo and longer follow-up is required to draw firm conclusions.

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A 27 -year -old unmarried male presented with typical clinical features of lepromatous leprosy which was confirmed by slit-skin smear and histopathological examinations. He also had history of intra­venous use of heroin and tested positive for HIV-I antibody by ELISA and Western blot. This is the first case report of co-infection of leprosy and HIV from Manipur.

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An unusual case of tonsure trichotillomania is reported for its rarity and clinical interest

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