An elderly male developed multiple, pruritic seborrhoeic keratoses over the trunk and face along with the signs and symptoms of carcinoma of the rectum. After surgical removal of the tumour, the skin lesions showed evidence of regression. Sudden development of pruritic seborrhoeic keratoses in association with an internal malignancy indicated Laser-Trelat sign,

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The hypothesis of the role of Candida in the gut for provoking psoriasis was tested by treating 9 males and 6 females having stable psoriasis with 200,000 units of nystatin orally 4 times a day for a minimum of 6 weeks. Intradermal candidin test and throat swab and stool samples for culture of Candida were taken before and twice after (between 4 and 8 weeks) institution of the therapy. Various Candida species isolated before therapy in 11 patients, disappeared after the therapy in 6. In the other 5 the colony counts came down. Only scaling became less in 4 patients. More than 50% clearance was noted in 2 patients. No improvement occurred in 9 patients. No obivous correlation between isolation and disappearance of Candida and persistence or clearance of lesions was observed. Immediate (Type-1) hypersensitivity response to candidin was positive in only 3 patients. Immediate hypersensitivity to Candida antigens -or its metabolic products does not appear to have any role in the pathogenesis of psoriasis.

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A 22 year old male patient suffering for 4 year from severe nodulo-cystic acne and scarring by systemic signs like fever, malaise, polyarthralgia, loss of; weight and leucocytosis was diagnosed as a case of acne fulminans. When there was no response to routine, treatment and even systemic corticosteroid, he-was treated - with a low dose of oral retinoid, isotretinoin. He improved dramatically within 2 weeks, and there was no relapse after 18 weeks follow - UP.

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Cutaneous manifestations of chronic renal failure (CRF) were studied in 20 cases. Generalised pruritus was observed in 8 patients, ichthyotic skin changes of varying degree in 18 patients and hyperpigmentation of sun-exposed skin in 7 patients. Scaling, pallor and hair loss correlated strongly with the severity of CRF. Skin biopsy performed in 5 cases revealed mild hyperkeratosis, reduction of prickle cell layer and flattening of rate ridges. No significant dermal changes were detected.

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Two cases-had meningococcal septicemia with vasculitis of skin. Out 9 year old female developed generalised ,asymptomatic, purpuric atrophic plaques on the limbs, trunk and face on the fourth day of high fever. The second patient was 20 year old male who developed purplish plaques. Nodules, and bullae mainly on the extensor surface of the hands and feet on the tenth day, of high fever. Bullae had clear fluid and bluish-black peripheral rim

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Three siblings of a family developed atrophoderma vermicularis, presenting as itchy, keratotic follicular papules all over the body mainly on the extensor aspect of the extremities and multiple atrophic pits involving the face and atrophic scars on other areas of the body.

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A 35 year old female presented with a pruritic plague on the dorsum of the left forearm. During follow-up it came to light that the lesion self-inflicted and served as a means to seek help for the underlying psycho-social problem in the patient's life.

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Delusion of parasitosis is a type of mono-symptomatic hypo-chondriacal psychosis common in elderly females whose response to drug therapy, usually pimozide, is variable. Two male patients presented with the delusion on their skin being infested with minute insects. One of them experienced presence of the inside the body cavities and spreading all over the body. They were treated satisfactorily with the neuroleptic drug, trifluoperazine.

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One hundred patients of urticaria were investigated to establish the causative agents. ,A detailed hist,6ry,:ccal examination and routine investigations led to detection of the cause m O/. patie s. Bacterial foci were responsible in 10%, worm infestations in 6%, drugs in 6%, insect bites in 3%, cold in 2%, chofine 'c in 4% and demographic in 3% rgl cases. In 60% cases, the cause was detected by intradermal tests with antigen extracts of pouen- hm fragments, dust, danders and food. Inhalantt were responsible in 35%: and foods in 25% cases. Among inhalants, pollen were found in 26%, insects in 1%, fungi in 9%, house dust and buffalo dander 'm 10/c each. In 6%, patients, no cause could be detected it; of extensive investigation.

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A case of bullous Darier's disease had typical brown follicular papules, greasy crusted papules discrete keratotic papules and vesiculo- bullous lesions on the dorsum of the hands and feet. In addition, characteristic lesions of xeroderma pigmentosum as extensivee, freekles intermingled with atrophic white, spots were present on the, face, trunk and limbs. This combination of bullous Darier's diseaese with xeroderma pigmentosum has not been reported earlier.

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A 40 years old male started developing increased folds of skin on the face, 15 days after an attack of measles. He had entropion of the upper eye lids, grade 2 piles and -moderate anaemia . There we're no other systemic abnormalities.

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The characteristic location on the upper part of back of chest and distinctive morphologic features-well deemed, white plaque with cobble-stone-like surface suggested the diaposis of hypochromaic ebrrhoe -sis in an adult ale. 6 0 ic k6rato Histopathology resembled seborrhoeic keratosis swept for the absence of pseudohom cysts and melanin piginent in the basal layer.

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A 9-month-old child developed fixed drug eruptions due to co-trimoxazole. Causative agent was confirmed by repeated provocation tests.

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Oral dapsone 200 mg daily for 16 weeks was tried on 52 adult patients, of whom 33 patients (males 17, femals 16) completed the study. No other topical or systemic medication was permitted. All the patients tolerated the drug very well. In 22 (66.5%) patients there was complete healing with hyperpigmentaiion after 16 weeks of therapy. In 7 (21.5%) patients partial respone was seen. There were 4 (12%) treatment failures. In patients with hiucosal lesions, the response started early and was seen more often (80.0%) No relapse was seen in any of the patients followed-up for a preiod of one year.

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