Palmar der matoglyphics were studied in two typical cases of Marfan's syndrome by ,using the standard ink and roller method. Simian crease, extra-digital transverse crease, 'increased atd angle, high position of the axial triradus and white lines were recorded.

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One hundred and eighteen cases of leprosy with ocular involvement were found to have corneal involvement out of a total 274 cases of ocular in volvement in leprosy. The common eye lesions observed were chronic conjunctivitis (54.01%), keratitis (47.07%), iritis (31.75%) and lagophthalmos (27.76%). In 38.98% of the cases, the time lag between the onset of skin lesions and corneal lesions was 5 to 15 years. The major causes, which lead to involvement of cornea, were corneal anaesthesia (116), lagophthalmos (76), ectropion (21), entropion (11) and trichiasis (4). Corneal blindness constituted 55.6% of total blindness in leprosy with ocular involvement.

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This report describes 2 females patients having contact dermatitis due to mustard khal the residue of,mustard seeds after the oil hasbeen extracted out. The dermatitis was caused by mbdng mustard khal with the cattle feed and was occurring on the hands and forearms, though the face, ear lobules and neck were also mvolved because of the practice of applying mustard oil on the hair. Patch tests were positive with the mustard khal and its fractionation products in both the patients and with mustard oil in one patient.

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Graded concentration of compound dithranol ointment were, tried' in 107 patients with plaque psoriais. The lowest concentration used was 0.05% which was gradully'mcreased, irrespective of the response. to the . um tolerable concentration. The ointment was applied over the patches in the evening and the lesions were exposed to the sun the next day. This was followed by a soap water bath. The process was repeated tiD 16 weeks or the disappearance of lesions whichever was earlier. A majority of the patients required a concentration of 0.25% for clearing and a few required 0.5% concentration. In 54 patients, there was complete clearing of the lesions and another 22% showed 75% clearance. Only 2% cases, there was no appreciable change in the skin lesions. Resistant sites were legs, elbows, lower back etc. Mild local side effm such as folliculitis, irritation of the surrounding normal skin and local pruritus occurred in some patients. In seven patients, c irritation required discontinuation of the therapy. Temporary staining of the fingertips and hair occurred as also staining of the No systemic side effects were observed.

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A case of Fabry' disease (angiokeratoma corporis diffusum universale) is reported. Presence of uncommon physical thick lips, large ears and proportion are high - lighted.

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A survey of 995 cases of leprosy revealed the prevalence of ocular involvement to be 275.4 per thousand. Lepromatous leprosy showed the highest prevalence. Majority of the cases were males, but prevalence of ocular involvement was higher in females. The 40-50 year age group showed the maximum prevalence. The time interval between the onset of skin lesions and the eye lesions, in majority of the cases was 5-10.

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One hundred and six cases comprising different of warts were included the study. The types of treatment tried were topical systemic and physical. Podophylin 25% in tincture benzoin co was very effective for genital warts, while electrocautery was successful in 87% cases of common warts. Systemic medication such as levamisole and thuja-200 did not give satisfactory results.

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Three Indian sibs with epidermodysplasia verruciformis (EV), born of consanguineous marriage, are _described. The lesions were hypopigmented, erythematous, flat papules present over the face, neck, trunk and upper extremities. Multiple Bowen's keratosis over the face in case 1 and 2, and squamous cell carcinomas over the forehead in case 1 and the scalp in case 2 were also present at the time of presentation. Cell-mediated immunity was depressed in all the three case. Viral particles were demonstrated in the nucleus by electronmicroscopy in the lesion of EV. No direct association with any HLA type could be established.

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Two hundred and seventeen histopathologically proved cases of mycetoma collected from the records of the pathology Department over a period I of 13 W years (from. January 1971 to May 1984) were studied using haematoxylin and eosin stained paraffin sections, and wherever necessary Gomori's silver methanamine technique, PAS stain, Gram's stain and Zeihl Neelson's stain to outline the morphological characteristics of the causative agents in the tissue and the surrounding tissue reaction.

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PUVA was used on thirty five psoriatic patients. Early and complete clearance 'of lesions was seen in all but two patients, between 5 to 35 days of treatment. There were no serious side effects.

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A 27-year-old male having scleromyxoedema is reported. The lesions were moderately pruritic, 2 to 3 mm papules situated over sheets of thickened, waxy skin on the face, neck trunk and extremities. Paraproteinemia was absent, though the bone marrow showed a mild plasma cell hyperplasia.

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In eight patients having extensive psoriasis, treated with hemodialysis, serum levels of LH, FSH, testosterone, T3, T4, ISH prolactin, insulin and cortisol were estimated before and after clinical imprmement. No differences were observd in hormone levels before and after diabmis. Serum prolaction lewis which were high to begin with remained so even after dialysis although the value had decreased slightly.

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To prevent deformities in the leprosy patients caused by burns, an attempt has been made to improve perception of the temperature sensation in the hypoaesthetic skin areas. The sensory loss in each lesion was first graded by determining the minimum temperature felt as hot (MTH) at the affected skin area in comparison with the MTH at the corresponding unaffected skin area by meana of a specially designed device named temperature- sensation testing and grading device. An intradermal injection containing 3.2 ug of histamine acid phosphate at the centre of the lesion led to a decrease in the MTH by 3 to goc in 8 out of 12 patients including one who had a complete loss earlier. This decrease in the MTH was maintained for 15 minutes in 6 patients. A repeat study in 10 of these patients gave similar findings. In another 40 patients, a' histamine-DMSO solution prepared by mixing I mg histamine acid phosphate with 1 ml of DMSO applied at the centre of the leprosy lesion led to a decrease in the value of MTH by 1-lfC in 14, including 3 patients who could not perceive even 500C as hot before the application. Fifteen minutes after the application, only 3 of these patients had a decreased value of MTH. Repetition of the experiment in 18 of these patients revealed similar results.

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Lengerhans cells (LC) were defined by indirect immunoperoxidast using OKT6 monoclonal antibody m the skin lesions of 10 untreated psoriasis patients. The distribution and the numbers of OKT6 + epidermal LC in the lesions was low in comparison to that found in the normal skin. In some of the lesions, T6 + LC could not be seen in the epidermis. This observation suggests that the reduction in LC may be a contributing factor in the pathogenesis of psoriasis.

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