A case of incontinentia pigmenti achromians is reported in a 20-year-old female. She had associated hyperkeratosis palmaris et plantaris and a high arched palate. Spontaneous repigmentation developed in some patches after the age of 12 years. Differentiating features of the dermatosis from classical incontinentia pigmenti, achromic nevus, piebaldism and vitiligo are briefly discussed.

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This report descsribes two cases of gonnorrhoea from whom Blactamase producing gonococci were cultured.

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A case of congenital leukemia cutis in a female child startling at birth and manifesting as erythematous papules and nodules all over the body, along with hepato-splenomegaly and terminating fatally is reported. This is an extremely rare disease.

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A case of lichen planus-like eruption following PUVASOL therapy is presented. The eruption could not be reproduced by patch test, photopatch test and clinical challenge with 8-methoxypsoralen given orally.

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In order to achieve better therapeutic results, 10 patients having pemphigus vulgaris were treated with repeated pulses of dexamethasone and cyclophosphamide. Each pulse consisted of 100 mg dexamethasone given intravenously in 5 % glucose over a period of 1 hour on three consecutive days. In addition, 500 mg cyclophosphamide was given with the pulse on the first day, followed by 50 mg orally daily even in between the pulses. Such pulses were repeated every 2-4 weeks depending upon the clinical activity of the disease. With this therapy, healing of skin lesions was generally much faster and the patient could as a rule be discharged within 4-5 days. Secondly, the side effects usually associated with prolonged corticosteriod therapy were far milder. In a follow-up varying from 13 ½ to 26 ½ months, 6 patients remained free from relapses for 6 to 14 ½ 2 months, while 4 patients continued to develop relapses at variable intervals sfter each pulse.

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The HLA associations reported so far have implication in diagnosis prognosis and prophylaxis for a few of the diseases and in several cases, they have helped to clarify disease heterogenicity. However ' the area where a full consensus is yet to be achieved is regarding the mechanism by which these disease associations with HLA antigens work. Numerous investigators have discussed various possible mechanisms in the light of individual diseases. In general diseases associated with HLA class I antigens may in some way involve cytotoxic T lymphocytes whereas those more strongly associated with HIA - class II antigens (-DR) may involve T helper or suppressor lymphocytes. With the availability of new genetic methodology, significant advances in our understanding of the inheritance pattern of some diseases have been made. Studies of the newly discovered HLA polymorphisms, such as the DQ and DP markers at the- cellular level (Class - 11 genes products) and restriction sites at the DNA level are likely to lead to new associations. Further, the discovery of the monoclonal antibodies recognizing distinct epitopes on HLA class - 11 molecules and DNA probes recognizing DNA flanking sequences would help greatly in providing much stronger genetic marker systems in these diseases.

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Langerhans cell population of normal human epidermis was counted using A Pase staining. No significant difference in density of Langerhans cells in relation to age, sex and various regions of the body was noted.

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Clinical features of 126 patients suffering from skin and genital warts are reported. Males comprised of 73.8% patients and the maximum number (30.2%) were in the age group 16-20 years. The commonest type (58.9%) of. wart was verruca vulgaris; the incidence of the other types was condyloma acuminata (12.7%). filiform and digitate warts

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The new oral aromatic retinoid (Tigason) was tried for the treatment of three Libyan patients with Darier's disease. The clinical response, was good but in two patients, side-effects necessitated stopping the treatment.

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Out of 148 consecutive male patients who attended the Skin and STD clinic for sexually transmitted diseases or related problems. 30 patients had pearly Penile Papules. The average age of these patients was 25 years. The incidence, among circumcised anduncircumcised patients was, almost equal. Twenty per cent of those with pearly penile papules felt that they had an S T D Plearly penile papules is a common cause of venereophobia.,

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During a survey conducted to study the spectrum of skin disease in a semi-urban community, 4133 inhabitants of all ages were examined by house-to-house visit. Skin diseases were detected in 1275 (30.84%)individuals. Of these, the majority (24.40/o) suffered from infective and parasitic diseases., The prevalence was higher than that reported by other studies conducted in other countries.

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The treatment modalities of one hundred VD patients prior to attending the VD clinic were studied. Quackery was the commonest method of treatment chosen by them followed by indigenous medicine, homeopathy and self-medication. Lack of investigations, lack of stigina and rapidity of treatment were (he main reasons for their approach to no specialists. In most cases they were motivated by their friends to choose the particular method of treatment. After visiting the clinic many developed faith in specialist treatment.

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A 3 year old girl having Hereditary sensory neuropathy, type II manifesting as congenital absence of pain sensation and trophic changes in the skin is reported. Conduction velocity study of the nerves of the hands and feet revealed a normal motor conduction, but sensory action potentials were absent. Differentiating features of this disease other type of hereatary sensory neuropathies and congenital indifference to pain briefly discussed.

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Apparently normal skin at the periphery of the lesions of various types of leprosy has been studied, for histological confinement of the disease. T-r cases showed, good confinement without any histological change in the normal skin, while 21.4% of BT cases, 42.8% of BB cases, 66.6% of BL cases and 80%'of LL cases showed some of the changes viz epidermal atrophy, subepidermal clear zone, acid fast bacilli, attempt at granuloma formation, diffuse lymphocytic infiltration and nerve involvement. Loss of confinement was directly proportional to the expected deficiency in the immune status of the patients from BT to.LL.

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