One hundred new cases of pyodenna attending King George Hospital, Vishakhapatnam were investigated bacteriologically with antibiotic sensitivity of all the strains isolated and phage typing of coagulm positive staphylocci. Among these 50 had impetigo and 15 each ahd furunculosis and fouiculitis. The remaining included various other clinical entities. Children under 10 years were observed to have high incidence of pyoderma. A total of 88 strains of staphylococci (77 coagulase positive and 11 coagulase negative strains) 25 strains of beta haemolytic streptococci and 3 strains of Klebsiella were isolated. Staphylococci were found to be the commonest aetiological agents either single or in association with other organisms. Of the 76 strains of coagulase positive staphylococci 32 strains were not phage typable and among the 44 typable strains 17 (38%) belonged to group III and 15 (36.5%) to mixed group. Coagulase positive staphylococci showed high sensitivity to garamycin, kanamycin and erythromycin and high resistance to penicillin and streptomycin. Multiple drug resistance was also high among these strains. Coagulase negative staphylococci were found to be more sensitive with less incidence of multiple drug resistance. Most of multiple drug resistant strains belonged to group III phage types. Beta haemolytic streptococci were found to be highly sensitive to all the antibiotics tested.

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A case of keratoderma hereditaria mutilans in a 24 years old lady with associated marked ichthyosis and acanthosis nigricans is reported. A short literature review is given

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Forty eight patients having psoriasis were studied with puvasol therapy. Pre-treatment haemogram, platelet count, liver and renal functions were done. To begin with 40 mgm of 8 MOP were given at 10.30 a m and at 12.30 p m sunlight exposure for period varying from 5-30 minutes. After 8 to 12 weeks tri, bi and weekly maintenance therapy was given. The sunlight exposure calculated by the photometer was 8-12 Joules/cm2 per day. The grading of response was undertaken on the basis of three different aspects (1) Subsidence of lesions, Grades were given as excellent with 100% subsidence, good with 90100%, fair with 50-90% and poor with less than 50% subsidence (2) Statistical point score as per Wallace's classification and depending on type and morophology of lesions and (3) Response related to duration of therapy. Of 38 patients with psoriasis vulgaris 21 showed excellent to. good response. All six cases of psoriasis e ma (100%) showed excellent to good response. Of the three cases of pustular psoriasis, one showed 90- 100%, and 2, 50-90% subsidence. Puvasol therapy proved to be effective, non toxic and inexpensive in psoriasis. In the erythrodemic and pustular phase for the first time the results were encouraging.

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A case of black piedra of scalp in a female resident of Varanasi is reported and the differentiating features of the two varieties of piedera described.

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An unusual case of angiokeratoma of Imperial and Helwig type with detailed clinical and histological features is presented. The difficulty in the clinical recognition of this type of vascular malformation is emphasised.

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A case of giant chancroid following rupture of inguinal bubo and having systemic symptoms is described. Response with sulfa and streptomycin combination was excellent and the lesion healed completely in 3 weeks. Early diagnosis and treatment of chancroid will prevent this debilitating complication.

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Cutaneous manifestations are found in 60 to 70% cases of tuberous sclerosis and consist of adenoma sebaceum, periungual fibromatas, cafe au lait spots, shagreen patches and white macules. Our patient showed unusual skin manifestations like spotty pigmentation on the chest, back and abdomen and hyperkeratosis palmaris et plantaris.

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A quantitative assay of porphyrins in blood, urine and stool of 30 patients with atopic dermatitis, 17 without and 13 with bronchial asthma was done. Rimington's technique for the estimation of porphyrins was employed. No statistically significant difference in porphyrin levels was observed between patients without and with bronchial asthma.

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Thirteen cases of contact dermatitis due to shaving creams are being reported to highlight the clinical features, diagnosis and management of this disease.

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In the present study twelve albino rats were taken animals were kept as controls and on 8 rats hair dye was applied daily on the head and test of the body. After 2 months chromosomal study was done from bone marrow by the direct Chromosomal damage was noted in the hair-dyed animals.

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Gross examination of the jejunal mucosal biopsy specimens has only a limited value, as out of 13 cases revealing normal morphology only 5 showed normal histology in psoriasis group while out of 7, only 4 cases revealed a, normalhistology in eryttwodetma group. Changes were observed more frequently in [email protected]'than in erythrodenna.,In both the groups [email protected]@[email protected] relation between the histologic alterations and the age, or the duration of the illness., litpsis to a great extent mucosal changes are related to the extent of skin involvement No such relation could be established in cases of erythroderma. In the absence of clinical features suggestive of derangements of the gastrointestinal tract it istempting to pressume that the, ent Mpathy is secondary to the skin lesions.

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