The disease phrynoderma was comprehensively reviewed from all aspects including aetiology, clinical features, histopathological and biochemical changes from available literature. The aetiology of the disease could not be definitely established at the present state of our knowledge. It appears possible that the disease may result from certain dietetic deficiencies in which case, the result of treatment are good, or it may be the result of a genetic predisposition, in which case treatment is often infructuous. It is, however, possible that both dietetic deficiency and a genetic predisposition may play a part in the causation of the disease, in every case, to a lesser or greater extent.

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The effect of complamina administered in a parenteral-cum-oral schedule in the treatment of recurrent intractable ulcer in leprosy is reported. A group of six patients belonging to tuberculoid type who had trophic plantar ulcers showed response in no way different from a control group receiving placebos. Four out of a group of five lepromatous patients with chronic non-plantar ulcers on legs, refractory to other lines of treatment responded extremely satisfactorily to complamina under the conditions of administration and dosage schedule. A larger trial including exclusively such non-plantar ulcers with a higher dosage schedule seems justifiable

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398 patient with leprosy were studied for various eye lesions. Eye lesions were mostly seen in patients whose disease was present for 4 years or more. Cases with more than 40% of body surface involvement were more likely to manifest eye lesions. Duration of treatment did not govern the ocular manifestations. Eye damages were milder in patients who had treatment for more than 12 years. Eye changes were less in patients with non-lepromatous leprosy as compared to those with lepromatous leprosy.

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A rare case of condyloma acuminata involving the thigh is reported. There were no associated lesions of similar nature on the genital areas.

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Seventy uncomplicated cases of psoriasis were subjected to standard and prednisolone glucose tolerance test. 14.3% cases revealed an abnormal glucose tolerance testand 12-5% mm an abnormal prednisolone tolerance test. Control series has revealed 2.4% abnormal GTT.

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Prevalance of syphilis is estimated by using du= parameters: (i) results of initial VDRL screwing-, (ii) results of FrA-200 used as confirmatory test on low positive reactors (LPR); and (iii) clinical findings.on the LPR. Variable prevalence rates can be reported depending on how these parameters.are utilised. These rates are computed for 1479 dermatology patients above 15 years of age and 663 9 maternity patients studied during 1969-73. On the basis of FrA-200 test, the BFP rate is as high as 83.3%. Probable factors contributing to this high BFP rate are discussed. The inconsistencies between serological and clinical diagnoses are also analysed. It is stressed that clinical judgment by the physician in assessing the LPR has still great importance considering the non-specific and not infalliable nature of the VDRL and FTA-200 tests respectively.

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