Twenty-one patients suffering from bilateral steroid-responsive dermatological lesions were studied in a double-blind comparative fashion for clinical evaluation of Propaderm and Hydrocortisone. The period of treatment was fixed arbitrarily or 3 weeks and patients were subsequently followed up for a further period of 2 weeks after the discontinuation of the therapy. The response to Propaderrn treatment quick and was found to be highly significant as compared to Hydrocortisone therapy. No untoward side- effects were noticed with either of the drugs.

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The vascular spiders described by medical text books as very common finding in cirrhosis of liver are rarely seen in Indian patients. Our study on 300 cases of alcoholic cirrhosis of liver revealed the presence of spider nevi in 2% of patients as compared with the figures given by the western text books which vary from 60 to 80%. They should not be given the importance as physical sign in Indian cirrhotics.

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The case of a 25 years old male suffering from lues maligna is reported. The skin lesions consisted of multiple circular ulcers covered with lainellar crusts and responded to therapy with benzathine penicillin.

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A characteristic pattern of pigmentation is presented in 200 cases with a short discussion and evaluation of various etiologic factors. Melanosis mainly affected the periphery of face, neck, infraclavicular region and upper back. It was dark brown and reticular -or rippled in pattern. Seborrhoeic diathesis and use of drugs and chemicals may be the causative factors.

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A case of dermatitis herpetiformis in a child of two and a half years is reported. Puritic mostly bullous with wide spread distribution over the body which is not common is discussed. Important feature of its unresponsiveness to sulpha pyridine, which gives better results in adults and involution of the lesions with dapsone therapy is obvious.

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An unusually big foreign body impacted in the urethra resulting ' in retention of the urine and its management is presented. Attention is also dmwntothefactdwmanymoremmof foreign body in the genito urinary tract might go undetected.

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A study of urticaria pigmentosa developing in a child of seven months has been reported in detail. The lesions developed ai the age of three months, were multiple nodular lesions, yellow to dull brown in colour and varied in sizefrom apeanutto alarge plaque. No systemic involvement was noted. Literature has been extensively reviewed and the histologic and

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Twenty cases of vesiculo-bullous dennatoses were examined. Histopathological examination was done in all but a few cases. In majority of the conditions, biopsy findings based on histopathological examination are in agreement with clinical diagnosis. The importance and the diagnostic significance of paper electrophoresis was discussed with a review of the literature. Increase in alpha, and gamma globulin is said to be found in acute and chronic infections, even though this feature was noted in epidermolysis bullosa and in erythema multiforme. In pemphigus there is low level of all fractions of proteins. The importance of further research in this field, particularly in large number of similar entities keeping in view the stage of the vesicles is stressed to arrive at a firm and useful conclusion.

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