Basal serum levels of total testosterone, dehydroepiandosterone sulfate (DHEA, - S) and androstenedione (A4) were measured by radioimmunoassay in 100 patients of acne vulgaris, and in 100 age and sex matched acne free healthy subjects. In males with acne the mean serum testosterone levels were marginally and the DHEAS and A4A levels were significantly higher as compared to controls (p). Females with acne had significantly higher levels of testosterone (p<0.001), DHEA-S (p<0.001) and (p < 0.01) than controls. Our data suggest that increased adrenal androgen levels in plasma may be responsible for treatment resistant acne vulgarism

Fifty-two patients of skin lichen planus conforming to the clinical and histopathological description were subjected to the different liver function tests. Age and sex matched clinically normal equal number of persons were taken as controls to exclude liver disorders.] Seven (13.46%) of the patients used to consume mild to moderate amount of alcohol. Nine (17.30%) cases gave the history of jaundice in the past and all of them had hepatomegaly. Otherwise hepatomegaly was observed in 37 (71.15%) cases. None of the healthy controls had hepatomegaly. Aspartase iminotransferase (AST) alanine aminotransferase (ALT) and alkaline phosphatase was raised in 11 (21.15%), 4 (7.69%) and 10 (19.23%) cases respectively. HBsAg was not detected in any of the 52 patients.The most contradictory finding was the revelation of raised immunoglo bulin of G, A or M either singly or in different combinations. IgG and IgA were raised in 32 (61.53%) cases while IgM in 26 (50.0%).

Ten commonly used toilet bar soaps were tested for their respective irritancies usin Kligman.and Wooding's technique of . 9 evaluation of mild irritants of human skin. Five per cent soap soulations were prepared and their pH measured, IT 50 and irritancy scores were calculated. There was to correlation between pH and IT 50 or irritancy scores and lux pink was least irritant followed by New Cinthol, Pears and lifebuoy.

In a control study of 75 male patients of coudyloma acuminata Dinitrochlorobenzene. (DNCB) was used as immuno therapeutic agent. The DNCB was not found to be superior in curing the warts when compared with control groups. No serious side effects and toxic were observed with DNCB.

A case of granular cell myoblastoma in a twenty four year old lady is reported.

A young firl who was on anti-leprosy treatment presented with exfoliative dermatitis, which was considered drug, induced. Withdrawal of the drugs resulted in EXACERBATION OF DERMATITIS amelioration of the cutaneous symptoms but subsequently she developed features of neuritis. Careful history and histopathological interpretation confirmed Type I reaction.

Three patients who developed onycholysis following doxycycline therapy for acne vulgaris are reported. In only one patient, it was associated with a phototoxic reaction.

A five months old female child with a rare condition, nevus unilateralis comedonicus is reported. Treatment with topical tretinoin cream resulted in partial improvement.

A patient who developed: multiple subcutaneous pheomycotic cysts three months after an injury, revealed a growth of Phialpoh4ra gougerotii on culture. lesions showed a lymphatic spread along the forearm, a feature undocumented in this disease.

A case of unilateral herpes zoster ophthalmicus (HZO) is reported with ipsilateral involvement of III, IV and VI cranial nerves which led to extra ocular muscles palsy presenting as total ophthalmopegia along with ptosis, cycloplegia and dilated non reactive pupil.

A 6-year-old girl had gradully progressive, ennumerable hypopigmented lesions of variable size present on covered as well as on sun exposed parts of the body for the last 3 years. The histopathological findings were compatible with idiopathic guttate hypomelanosis.