Growth characters and anti-microbial susceptibility of 36 leprosy-derived mycelial isolates resembling Dermatophilus species have been studied. The organism gave actinomycetoid type of growth on CMY-PD agar. In liquid medium, with similar constituents, the growth consisted of turbidity in the medium with a sheath on the top and mucoid deposit at the bottom. All the 36 isolates tested were sensitive to Rifampicin and Oflaxicin. 12 isolates showed resistance to DDS.

Clinico-epidemiological features of 142 smear positive case of oriental sore detected out of 394 clinically diagnosed cases, in 1 year duratin, are described. A distinct endemic belt of high cases density was observed in the thickly populated area of old walled city of Bikaner in close proximity of terrains revines & having high dog population. The current epidemiologic status of the disease has been evaluated. 72.53% cases were form age group 5 to 29 years; 60.56% of the positive cases had lesion on exposed body parts; lesions were ulcerative in 59.15% of cases and 73.94% of cases had single lesion on body. The majority of cases (73.94%) had duration of lesions from 1 to 3 months. 68.31% cases belonged to low socio-economic group. Males were affected more than females.

Clinical and bacteriological study was carried out in 100 cases of Pyodermas to find out the causative organism and their antibiotic sensitivity patterns. Maximum cases were of impetigo (31%) followed by furunculosis (24%), folliculitis (22%), pyogenic intertrigo (6%), sycosis and carbuncle (6% each), ecthyma (2%) and cellulitis (1%). Majority of the cases belonged to age group of 0-10 years. A total of 99 isolates from 100 cases with pyodermic lesions were isolated. Single infecting organism was isolated from 85.85% and more than one type of organisms from 7.07% of cases. No organism was isolated from 9.09% of cases. Coagulase positive Staphylococcus (80.8%) was the predominant species isolated followed by Beta-haemolytic streptococcus (13.13%) and Esch. coli (3.03%). Staphylococcus aureus showed highest sensitivity to Gentamicin, Erythromycin and Cephalexin and high resistence to Tetracycline, Penicillin and Polymixin. Streptococcus Beta-haemolyticus was highly sensitive to Gentamicin, Cloxacillin and Tetracycline and less sensitive to Penicillin and Ampicillin. Most of the strains were found to be resistant to one or more antibiotics.

Efficacy of Cetrizine and Astemizole was comapared in 50 cases of chronic Idiopathic urticaria. Patients were divided into 2 groups viz A and B. Before starting the therapy, routine investigations were carried out to rule out any septic focus. Prior to treatment, 1 week before all medications were withdrawn. Cetrizine and Astemizole, 10 mg each, were given as a single daily morning dose for 1 month and patients were followed up for 1 month.

Erythrocyte glucose-6-phosphate dehydrogenase (G-6 PD) enzyme was studied in 30 patients of lichen planus diagnosed clinically and confirmed by histopathology. There was significant decrease in G-6 PD in patients in comparison with controls. Inspite of this it is very difficult to suggest any aetiological role of erythrocyte G-6 PD in causation of lichen planus.

Efficacy of topical 5% Acyclovir in 35 cases of Herpes zoster (HZ) was compared with 10 cases using placebo. Complications like PHN, scarring and keloid was treated with laser. Topical 5% acyclovir was found to be very effective in controlling symptoms and PHN if applied in early stage of eruption.

Pathogenesis of recurrent pyodermas is far from clear, but recent literature has stressed the importance of host defences especially the neutrophil function. Neutrophil chemotaxis was estimated in 32 patients of recurrent pyodermas and in equal number of controls by the skin window method of Rebuck and Crowley. No significant variation could be detected in the neutrophil chemotaxis among controls and patients (P>0.05%).

A patient of Granuloma faciale with atypical features and response to dapsone is reported.

A 53-years -old male developed pruritic, papular, vesicular and papulovesicular rash on trunk and proximal limbs. Patient gave history of excessive sun exposure. Histopathology revealed intra-epidermal clefts at various levels with acantholytic and few dyskeratotic cells. This case of transient acanthyolytic dermatosis (TAD) was treated in 6 weeks with 150 mg dapsone daily, antithistaminics and topical steriods.

A patient with disseminate discoid lupus erythematosus who developed squamous cell carcinoma in a lesion of discoid lupus erythematosus situated over a relatively photocoverd area is described. Histopathology and direct immunofluroscence confirmed the diagnosis.

Squamous cell carcinoma develong in a preexisting plaque of lichen simplex chronicus of 20 years duration is reported.

Here we present a rare case of granular cell tumor in the tongue which gave a false impression of a calcified nodule.

One 32 years male had itchy, erythematous, tense bullae which were complicated by contact - irritant eczema due to indigenous medication. Later he developed secondary infection and maggot infestation. On tapering off steroids he developed fresh crops of haemorrhagic tense bullae. Clinical diagnosis of Brunsting Perry Cicatricial Pemphiogoid (BPCP) was confirmed by subepidermal bullae. Bullae were controlled with 150 mg dapsone daily.

An 11 year old male having zosteriform angiokeratoma circumscriptum is reported for its unusual association with Marfanoid habitus.

A case of pachyonychia congenita Type I, a rare disorder is presented. There was no oral leucokeratosis and the family history was also negative.

A unilateral red ear can be a common presentation in angioedema, leprosy, lupus vulgaris and contact dermatitis. Here we present an unusual case due to tinea incognito.

A 1½ year old female baby had pearly papules and crusting over the nasolabial folds, earlobes, nape of the neck and scalp. She had gingival hypertrophy and showed osteolysis of tibiae on roentgenography. Biopsy was characteristic of juvenile hyalline fibramatosis.

A case of "bilateral Naevus of Ota", developing cutaneous pigmentation after an attack of fever is reported.

A 45 years old male presented with multiple violaceous papules over flexor aspects of both hands and anterior aspect of legs of 3 years duration and a proliferative cauliflower like growth with ulceration and bleeding plaque over the anterior aspect of the left leg of 6 months duration. The histopathology of the left leg lesion proved to be hypertrophic lichen planus with squamous cell carcinomatous changes.

Milker's nodules were seen in a 22 year old rural girl who was milking cows. Asymptomatic symmetrically placed nodules with target appearance were present over dorsum of both index fingers. Diagnosis was confirmed histopathologically.

A case of a 25 year old male with Scleromyxedema is reported. The typical papular lesions with underlying woody, fibrous, sclerosis of skin were seen.