There have been conflicting views as to the precise nature of erythrokeratodermia variabilis. It has been suggested that it is a "retention' hyperkeratosis. Light and electron microscopic studies were undertaken to study the morphological changes that take place in, the epidermal cells and their bearing on the pathogenesis in two sisters, suffering from this rare disorder. Histopathologic changes as seen under the light microscope were non-specific. Ultrastructural studies showed a thickened basement membrane and presence of large amount of tonofibrils in the basal cells, some aggregating to form clumps. In the suprabasal and lower spinous cells keratohyihne granules were present. The cells of the upper spinous layer were full of keratohyaline material. Normally material is only seen in the granular layer (transforming phase). Membrane-coated granules were decreased in the cells of upper spinous layer. Formation of keratohyaline granules in the suprabasal and spinous cells (synthetic phase) is possibly a major factor in the pathogenesis of erythrokeratodermia variabilis leading to an early or accelerated process of keratinisation and thus, it is unlikely to be a retention hyperkeratosis.

Twenty one patients having drug eruptions are reported. The causative drugs were confirmed by provocation Tests. Eleven patients had exanthematous eruptions. The causative drugs were thiacetazone (3), para aminosalicylic acid (3), i-sonicotine acid hydrazide (1), Stereptomycin (1), ethambutol (1 , carbamazepine (1 and phenytoin sodium (1). In 4 patients having toxic epidermal necrolysis, the causative drugs were para aminosalicylic acid (2) isonicotinic acid hydrazide (1), streptomycin (1), tetracycline (1) and phenobarbitone (1). Two of these patients reacted to two drugs each, namely, streptomycin and para aminosalicysclic acid; and tetracycline and phenobarbitone respectively. In 3 patients with ex o ative dermatitis , the causative drugs were isonicotinic acid hydrazide (1), streptomycin (1), thiacetazone (1), and chloroquine (1).One patient reacted to both thiacetazone and chloroquine. In 3 patients who presented as urticaria, the causative drugs were analgin (1), phenylbutazone (1), and dilantin sodium (1).

This is the first case report of cicatrical pemphigoid from India. The patient was a 58 year old rnale who--developed tense, dome shaped vesicles in the oral mucosa, followed 18 months later by blisters on the skin which healed by scarring, Symblepharon developed in both the eyes 23 months after the onset. Histologically, the split was subepuermace and direct immunofluorescent; subepidermal test on the patient's serum for IgG antibodies is negative.

Pilomatrixoma is an uncommon tumour,of the skin and is characterised by transition of [email protected] ceffs into shadow ceus. The, present cas6" described here because of certain unusual features namely origin from the male breast, production of hair within the tumour and associaion with mfiltr ductcarcinomaafin of the breast.

A case of maculo papular eruption caused by nicotinic acid is being reported. The causative durg was confirmed by repeated oral provocation.

A case of Acquired Digital Fibro Keratoma is reported in a woman with a short of the literature. This report is the first its kind in Indian literature.

A case of lichen sclerosis et atrophicus of scrotum and pubic region is reported which showed partial fusion of shaft to scrotum.

A case of depigmentation due to self sticking bindi, spectacles and plastic watch strap authenticated by loss of pigment on patch pigment on patch testing is reported. The relevant literature has been reviewed.

A case of biopsy proven verrucous haemangioma present from birth on the leg of a 39 years old female is reported. The lesions were presented as nodules in a linear distribution. The nodules used to ulcerate in summer with seropurulent discharge. The lesions were excised and a split-thickness graft was applid. There was on recurrence of the lesion 2,1/2 years later.