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Year : 2017  |  Volume : 83  |  Issue : 1  |  Page : 33-39

Pyoderma gangrenosum: A clinico-epidemiological study

Najeeba Riyaz1, Vineetha Mary2, Sarita Sasidharanpillai1, Riyaz A Roshin3, Ottakandathil Snigdha4, Ettappurath N. Abdul Latheef1, Saleem Rahima1, Valiaveetil Bindu1, Ravindran N Anupama5, Deepthi N Sureshan1, Pentam Veil Beegum Sherjeena1 
1 Department of Dermatology, Government Medical College, Kozhikode, Kerala, India
2 Department of Dermatology, Government Medical College, Kottayam, Kerala, India
3 Department of Dermatology, Amina Hospital, Perinthalmanna, Kerala, India
4 Department of Dermatology, Lisa Skin Clinic, Kozhikode, Kerala, India
5 Department of Dermatology, Valluvanad Hospital, Ottappalam, Kerala, India

Correspondence Address:
Sarita Sasidharanpillai
«SQ»Rohini', Girish Nagar, Nallalam PO, Kozhikode - 673 027, Kerala
India

Background: Pyoderma gangrenosum is a neutrophilic dermatosis of unknown etiology, with inconstant systemic associations and a variable prognosis. Aims: To study the clinical features and systemic associations of pyoderma gangrenosum and its response to treatment. Methods: All patients diagnosed to have pyoderma gangrenosum at the dermatology department of the Government Medical College, Kozhikode, from January 01, 2005 to December 31, 2014 were included in this prospective study. Results: During the 10-year study period, 61 patients were diagnosed to have pyoderma gangrenosum. A male predilection was noted. The most common clinical type was ulcerative pyoderma gangrenosum (90.2%). More than 60% of patients had lesions confined to the legs; 78.7% had a single lesion and 27.9% had systemic associations. Most patients required systemic steroids. Patients with disease resistant to steroid therapy were treated with intravenous immunoglobulin G and split-thickness skin grafts under immunosuppression induced by dexamethasone pulse therapy. All except one patient attained complete disease resolution. Limitations: The main limitation of our study was the small sample size. Conclusions: The male predilection documented by us was contrary to most previous studies. We found split-thickness skin graft to be a useful option in resistant cases. More prospective studies may enable the formulation of better diagnostic criteria for pyoderma gangrenosum and improve its management.


How to cite this article:
Riyaz N, Mary V, Sasidharanpillai S, Roshin RA, Snigdha O, Latheef EN, Rahima S, Bindu V, Anupama RN, Sureshan DN, Sherjeena PV. Pyoderma gangrenosum: A clinico-epidemiological study.Indian J Dermatol Venereol Leprol 2017;83:33-39


How to cite this URL:
Riyaz N, Mary V, Sasidharanpillai S, Roshin RA, Snigdha O, Latheef EN, Rahima S, Bindu V, Anupama RN, Sureshan DN, Sherjeena PV. Pyoderma gangrenosum: A clinico-epidemiological study. Indian J Dermatol Venereol Leprol [serial online] 2017 [cited 2020 Oct 22 ];83:33-39
Available from: https://www.ijdvl.com/article.asp?issn=0378-6323;year=2017;volume=83;issue=1;spage=33;epage=39;aulast=Riyaz;type=0


 

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