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Year : 2008  |  Volume : 74  |  Issue : 4  |  Page : 352-356

Fine needle aspiration cytology in leprosy

PVS Prasad1, Raj Varghese George1, PK Kaviarasan1, P Viswanathan2, Rehana Tippoo2, C Anandhi3 
1 Department of Dermatology Venereology and Leprosy, Rajah Muthiah Medical College and Hospital, Annamalai University, Annamalai Nagar-608 002, India
2 Department of Pathology, Rajah Muthiah Medical College and Hospital, Annamalai University, Annamalai Nagar-608 002, India
3 Department of Microbiology, Rajah Muthiah Medical College and Hospital, Annamalai University, Annamalai Nagar-608 002, India

Correspondence Address:
PVS Prasad
88 AUTA Nagar, Sivapuri Post, Annamalai Nagar-608 002, Tamil Nadu
India

Background: Laboratory diagnosis of leprosy by slit skin smear and skin biopsy is simple but both techniques have their own limitations. Slit skin smear is negative in paucibacillary cases whereas skin biopsy is an invasive technique. Fine needle aspiration cytology (FNAC) from skin lesions in leprosy with subsequent staining with May-Grunwald-Giemsa (MGG) stain has been found useful. Aim: To evaluate the possible role of cytology in classifying leprosy patients. Methods: Seventy-five untreated cases of leprosy attending the outpatient department were evaluated. Smears were taken from their skin lesions and stained using the MGG technique. Skin biopsy was also done from the lesions, which was compared with cytology smears. Results: A correlation of clinical features with FNAC was noticed in 87.5% of TT, 92.1% of BT, 81% of BL, and 66% of LL cases. Correlation of clinical with histopathological diagnoses revealed 12.5% specificity in TT leprosy, 55.3% in BT, 52.4% in BL and 50% in LL, and 100% in neuritic and histoid leprosy cases. Both correlations were found to be statistically significant by paired t test analysis. Thus, it was possible to distinguish the tuberculoid types by the presence of epithelioid cells and the lepromatous types by the presence of lymphocytes and foamy macrophages. Conclusion: FNAC may be used to categorize the patients into paucibacillary and multibacillary types, but is not a very sensitive tool to classify the patients across the Ridley-Jopling spectrum.


How to cite this article:
Prasad P, George RV, Kaviarasan P K, Viswanathan P, Tippoo R, Anandhi C. Fine needle aspiration cytology in leprosy.Indian J Dermatol Venereol Leprol 2008;74:352-356


How to cite this URL:
Prasad P, George RV, Kaviarasan P K, Viswanathan P, Tippoo R, Anandhi C. Fine needle aspiration cytology in leprosy. Indian J Dermatol Venereol Leprol [serial online] 2008 [cited 2020 Nov 27 ];74:352-356
Available from: https://www.ijdvl.com/article.asp?issn=0378-6323;year=2008;volume=74;issue=4;spage=352;epage=356;aulast=Prasad;type=0


 

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