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Year : 2006  |  Volume : 72  |  Issue : 3  |  Page : 203-206

Study of desmoglein 1 and 3 antibody levels in relation to disease severity in Indian patients with pemphigus

Bhushan Kumar1, Sunil Arora2, Muthu Sendhil Kumaran1, Rajesh Jain1, Sunil Dogra1 
1 Departments of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
2 Departments of Immunopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Correspondence Address:
Bhushan Kumar
Department of Dermatology, Venereology and Leprology,PGIMER, H. No. 81, Sector 16, Chandigarh 160 015
India

Objectives : To conduct a cross-sectional study to compare Dsg1 and Dsg3 antibody levels independently with severity of disease activity in pemphigus vulgaris (PV) and pemphigus foliaceus (PF). Methods : Blood samples from 44 patients with pemphigus (PV-38, PF-6) were analyzed using ELISA. The severity of skin and mucosal disease was graded using a score from 0 to 3. Results: A statistically significant correlation between increase in Dsg 3 antibody titres with severity of oral involvement and Dsg 1 titres with severity of skin involvement was found in both PV and PF patients ( p <0.01). However, we were unable to demonstrate a relationship between increased titres of Dsg1 and Dsg 3 antibodies with oral and skin involvement respectively. Conclusion : This study suggests that the severity of skin and oral disease in pemphigus is determined by the quantities of Dsg1 and Dsg3 antibodies respectively.


How to cite this article:
Kumar B, Arora S, Kumaran MS, Jain R, Dogra S. Study of desmoglein 1 and 3 antibody levels in relation to disease severity in Indian patients with pemphigus.Indian J Dermatol Venereol Leprol 2006;72:203-206


How to cite this URL:
Kumar B, Arora S, Kumaran MS, Jain R, Dogra S. Study of desmoglein 1 and 3 antibody levels in relation to disease severity in Indian patients with pemphigus. Indian J Dermatol Venereol Leprol [serial online] 2006 [cited 2020 Nov 24 ];72:203-206
Available from: https://www.ijdvl.com/article.asp?issn=0378-6323;year=2006;volume=72;issue=3;spage=203;epage=206;aulast=Kumar;type=0


 

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