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Year : 1998  |  Volume : 64  |  Issue : 2  |  Page : 71-74

Comparative evaluation of topical benzoyl peroxide, metronidazole and benzoyl peroxide - clindamycin combination in treatment of acne vulgaris

VK Jain, KL Chopra, Surabhi Dayal 
 Department of Skin, V.D. and Leprosy, Pt.B.D.Sharma, P.G.I.M.S., Rohtak-124 001, India

Correspondence Address:
V K Jain
II/9J, Medical Campus, Rohtak - 124001, Haryana
India

Forty patients of moderately severe acne were treated with either 5% benzoyl peroxide - 1 % metronidazole (Group l-20 patients)or 5% benzoyl-1 % clindamycin (group II 20 patients) for 8 weeks. The patients were evaluated at 2 weekly intervals by spot counting of the lesions. The mean reduction in non inflammatory lesion counts was 75.4% in group I and 76.73% in group 1 1 and the mean reduction in inflammatory lesion counts was 73.80% in group I and 76.41% in group II. Both the topical combinations were found to be equally and highly effective in the treatment of moderately severe acne. Side effects in the form of dryness and scaling were seen in 15% patients of each group. Our study also supports the combination of topical antimicrobial agents to prevent irritation and broaden the therapeutic spectrum by using agents with different mechanisms of action which are effective against different types of acne lesions.


How to cite this article:
Jain V K, Chopra K L, Dayal S. Comparative evaluation of topical benzoyl peroxide, metronidazole and benzoyl peroxide - clindamycin combination in treatment of acne vulgaris.Indian J Dermatol Venereol Leprol 1998;64:71-74


How to cite this URL:
Jain V K, Chopra K L, Dayal S. Comparative evaluation of topical benzoyl peroxide, metronidazole and benzoyl peroxide - clindamycin combination in treatment of acne vulgaris. Indian J Dermatol Venereol Leprol [serial online] 1998 [cited 2020 Nov 29 ];64:71-74
Available from: https://www.ijdvl.com/article.asp?issn=0378-6323;year=1998;volume=64;issue=2;spage=71;epage=74;aulast=Jain;type=0


 

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