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Glucagonoma syndrome with atypical necrolytic migratory erythema

1 Department of Dermatology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China
2 Department of Dermatology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

Correspondence Address:
Jinjing Jia,
No. 111, Dade Road, Yuexiu District, Guangzhou 510120, Guangdong Province
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijdvl.IJDVL_588_18

PMID: 31368453

Necrolytic migratory erythema is most commonly associated with glucagonoma syndrome. We report a rare case of glucagonoma syndrome with necrolytic migratory erythema presenting as pruritic papules and follicular pustules in a 57-year-old woman; showing eosinophilic infiltration on histology. However, the final diagnosis was confirmed by demonstrating neuroendocrine tumour on histopathological examination of the liver metastases. Nutrition therapy was administered as a palliative treatment. This case also highlights the atypical clinical features and nonspecific histology of necrolytic migratory erythema which makes the diagnosis difficult.

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