| ORIGINAL ARTICLE |
|
| Year : 2020 | Volume
: 86
| Issue : 6 | Page : 643--648 |
Expression of CD117 and platelet-derived growth factor receptor α in patients with alopecia areata
Saritha Mohanan1, Mary Theresa Sylvia2, Udayashankar Carounanidy1, Ramachandran V Bhat2
1 Department of Dermatology, Indira Gandhi Medical College and Research Institute, Puducherry, India
2 Department of Pathology, Indira Gandhi Medical College and Research Institute, Puducherry, India
Correspondence Address:
Dr. Saritha Mohanan
Department of Dermatology, Indira Gandhi Medical College and Research Institute, Puducherry
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/ijdvl.IJDVL_557_19
Background: Alopecia areata is a disease of uncertain, probably autoimmune etiology. The role of growth factors like platelet-derived growth factor and C-kit (CD117) in alopecia areata is unknown.
Aims: To compare the expression of CD117 and platelet-derived growth factor receptor α in tissue samples of alopecia areata and normal controls.
Methods: Thirty biopsy samples of alopecia areata and eighteen normal control samples were included in this cross-sectional study. Immunohistochemistry was done to detect the expression of CD117 and platelet-derived growth factor receptor α in cases and controls. The mean percentage of follicles expressing CD117 and platelet-derived growth factor receptor α was compared among cases and controls.
Results: The mean number of follicles expressing CD117 in anagen and catagen hairs differed significantly among cases and controls. The extent and intensity of staining with platelet-derived growth factor receptor α correlated significantly with the severity of alopecia areata based on the severity of alopecia tool score.
Limitations: Confirmation of the expression pattern of molecules observed in immunohistochemistry with western blot or polymerase chain reaction would have strengthened the report.
Conclusions: The expression of CD117 varied in cases and controls. The expression of platelet-derived growth factor receptor α correlated with the severity of the disease. This could explain how platelet-rich plasma works in the treatment of alopecia areata. Further studies are required to explore the role of these molecules in autoimmune pathogenesis.
[FULL TEXT] [PDF]*
|
