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 Table of Contents    
Year : 2020  |  Volume : 86  |  Issue : 3  |  Page : 325-328

A case of red ears

1 Internal Medicine, National University Hospital, Singapore
2 Paediatric Dermatology, National Skin Centre, Singapore

Date of Web Publication10-Oct-2018

Correspondence Address:
Dr. Yang Sun
673A Fern Grove Yishun Avenue 4 #08-632, 761673
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijdvl.IJDVL_828_17

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How to cite this article:
Sun Y, Yang SS, Tan LS. A case of red ears. Indian J Dermatol Venereol Leprol 2020;86:325-8

How to cite this URL:
Sun Y, Yang SS, Tan LS. A case of red ears. Indian J Dermatol Venereol Leprol [serial online] 2020 [cited 2021 Jan 20];86:325-8. Available from:

A 49-year-old lady, newly diagnosed with acute myeloid leukemia, was admitted for the first cycle of induction chemotherapy using daunorubicin (days 1 to 3) and cytarabine (days 1 to 7). She had no significant past medical history. On day 7, she developed marked erythema and edema over both her ears [Figure 1]. There were no auditory complaints, and otoscopic examination reviewed clear tympanic membranes with no effusions. The condition was associated with pruritic purpura over her limbs and trunk, with 5% of body surface area involvement [Figure 2]. There was no positive Nikolsky's sign or mucositis. Histology of the affected skin over the trunk demonstrated spongiosis and superficial perivascular mixed infiltrates composed of lymphocytes, histiocytes, plasma cells and neutrophils [Figure 3].
Figure 1:

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Figure 2: Purpura on the upper limb

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Figure 3:

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Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form, the patient has given her consent for her images and other clinical information to be reported in the journal. The patient understands that name and initials will not be published and due efforts will be made to conceal identity, but anonymity cannot be guaranteed.

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Conflicts of interest

There are no conflicts of interest.

  References Top

Miller KK, Gorcey L, McLellan BN. Chemotherapy-induced hand-foot syndrome and nail changes: A review of clinical presentation, etiology, pathogenesis, and management. J Am Acad Dermatol 2014;71:787-94.  Back to cited text no. 1
Hueso L, Sanmartín O, Nagore E, Botella-Estrada R, Requena C, Llombart B, et al. Chemotherapy-induced acral erythema: A clinical and histopathologic study of 44 cases. Actas Dermosifiliogr 2008;99:281-90.  Back to cited text no. 2
Levine LE, Medenica MM, Lorincz AL, Soltani K, Raab B, Ma A, et al. Distinctive acral erythema occurring during therapy for severe myelogenous leukemia. Arch Dermatol 1985;121:102-4.  Back to cited text no. 3
Baack BR, Burgdorf WH. Chemotherapy-induced acral erythema. J Am Acad Dermatol 1991;24:457.  Back to cited text no. 4
Jucglà A, Sais G, Navarro M, Peyri J. Palmoplantar keratoderma secondary to chronic acral erythema due to tegafur. Arch Dermatol 1995;131:364-5.  Back to cited text no. 5


  [Figure 1], [Figure 2], [Figure 3]


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