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Year : 2015  |  Volume : 81  |  Issue : 2  |  Page : 170--173

Spontaneous regression in an ulcerated CK7 positive Merkel cell carcinoma

1 Department of Dermatology and Venereology, Government Medical College, Kozhikode, Kerala, India
2 Department of Pathology, Government Medical College, Kozhikode, Kerala, India

Correspondence Address:
Dr. Anza Khader
Department of Dermatology, 5/1986 B, "Maskan" Rajiv Nagar Colony, PO Puthiyara, 673004 Kozhikode, Kerala
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0378-6323.152286

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Merkel cell carcinoma is an aggressive and frequently lethal tumor of the elderly, associated with sun exposure and immunosuppression which is less common in the dark-skinned. We report the case of a 40-year-old woman who presented with multiple slowly progressive, mildly itchy ulcerated plaques of size ranging from 2 × 3 cm to 5 × 7 cm on the left knee of 1 year duration. Skin biopsy showed diffuse dermal infiltration by small round cells with molding of cells and lymphocyte infiltration. The cells stained positive for cytokeratin (CK) 20, CK7, neuron-specific enolase, and chromogranin. The skin lesions underwent spontaneous regression within 1 month of skin biopsy and have not recurred during the past 2 years. The immune mechanisms triggered by biopsy possibly explain the spontaneous regression.


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Online since 15th March '04
Published by Wolters Kluwer - Medknow