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Year : 2013  |  Volume : 79  |  Issue : 6  |  Page : 739--749

New insights in the pathogenesis of type 1 and type 2 lepra reaction


Department of Dermatology and Sexually Transmitted Disease, University College of Medical Sciences, Guru Teg Bahadur Hospital, University of Delhi, Delhi, India

Correspondence Address:
Deepika Pandhi
Department of Dermatology and Sexually Transmitted Disease, University College of Medical Sciences, Guru Teg Bahadur Hospital, University of Delhi, Delhi - 110-095
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0378-6323.120719

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In the current scenario of leprosy elimination, lepra reactions (LRs) remain a major persistent problem. Type 1 LR (T1LR) and type 2 LR (T2LR) are the major causes of nerve damage and permanent disabilities. The immunopathogenesis of LR have recently become an important field of research, since it may provide the relevant targets for the early detection and control of these episodes. Presently, there are no uniformly acceptable laboratory markers for LR. Genetic and serum markers in human host may predict susceptibility to reactions as well as progression of nerve damage in leprosy. Therefore, a deeper understanding of the molecular mechanisms involved in LR may provide a rational strategy for early diagnosis and prevention of the catastrophic consequences of LR.






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Online since 15th March '04
Published by Wolters Kluwer - Medknow