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Year : 2012  |  Volume : 78  |  Issue : 3  |  Page : 407-

Sneddon syndrome associated with Protein S deficiency


1 Department of Neurology, Yuzuncu Yil University, Faculty of Medicine, Van, Turkey
2 Department of Dermatology, Yuzuncu Yil University, Faculty of Medicine, Van, Turkey

Correspondence Address:
Serap Gunes Bilgili
Department of Dermatology, Yuzuncu Yil University, Van
Turkey
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0378-6323.95483

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Sneddon syndrome (SS) is rare, arterio-occlusive disorder characterized by generalized livedo racemosa of the skin and various central nervous symptoms due to occlusion of medium-sized arteries of unknown. Seizure, cognitive impairment, hypertension, and history of repetitive miscarriages are the other symptoms seen in this disease. Livedo racemosa involves persisting irreversible skin lesions red or blue in color with irregular margins. Usually, SS occurs in women of childbearing age. Protein S deficiency is an inherited or acquired disorder associated with an increased risk of thrombosis. We present a 33-year-old woman with SS with diffuse livedo racemosa, recurrent cerebrovascular diseases, migraine-type headache, sinus vein thrombosis, and protein S deficiency. Protein S deficiency and with Sneddon syndrome rarely encountered in the literature.






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Online since 15th March '04
Published by Wolters Kluwer - Medknow