| CASE REPORT
|Year : 2012 | Volume
| Issue : 3 | Page : 354--357
Anaplastic lymphoma kinase-positive primary cutaneous anaplastic large cell lymphoma- Is it a new variant?
Muthu Sendhil Kumaran1, Madhukara Jithendriya2, Preethi Nagaraj2, Rajalakshmi Tirumalae3, Elizabeth Jayaseelan2
1 Department of Dermatology, Venerology and Leprology, PGIMER, Chandigarh, India
2 Department of Dermatology, St. John's Medical College Hospital, Bangalore, Karnataka, India
3 Department of Pathology, St. John's Medical College Hospital, Bangalore, Karnataka, India
Anaplastic large cell cutaneous lymphomas are clinically and pathologically heterogeneous, CD30 + (Ki-1) lymphoproliferative disorders. The importance of anaplastic lymphoma kinase (ALK) positivity is well known in the prognosis of primary systemic anaplastic large cell cutaneous lymphomas; however, the same in primary cutaneous anaplastic large cell cutaneous lymphomas is not much clear. Herein we report a 65-year-old male with an 18-month history of minimally pruritic localized nodulo-plaque lesion over lower back. Histology revealed cutaneous large cell lymphoma and immunohistochemical staining showed positivity for CD30, CD3 and ALK. The role of ALK positivity in pcALCL is discussed in this article.
Muthu Sendhil Kumaran
Department of Dermatology, Venerology and Leprology, PGIMER, Chandigarh
Source of Support: None, Conflict of Interest: None
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