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Year : 2012  |  Volume : 78  |  Issue : 1  |  Page : 64--67

The effect of H 1 and H 2 receptor antagonists on melanogenesis

1 Department of Dermatology, Al-Minya University, Al-Minya, Egypt
2 Color Foundation, Landsmeer, The Netherlands
3 Department of Pathology, Ain Shams University, Cairo, Egypt
4 Department of Histology, Al-Minya University, Al-Minya, Egypt

Correspondence Address:
Tag S Anbar
129 El-Hosaeny Street, Al- Minya, Post Code: 61111
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0378-6323.90948

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Background: Histamine was found to stimulate melanogenesis in cultured human melanocytes specifically mediated by histamine H 2 receptors via protein kinase A activation. Based on this finding, the effect of topically applied H 2 antagonist on UVB-irradiated Guinea pigs' skin was examined and found to be suppressive on the post-irradiation melanogenesis. Aims: In this study, we tried to explore the role of topically applied H 1 and H 2 receptor antagonists, in inhibition of UVB-induced melanization. Methods: The effect of topically applied H 1 and H 2 receptor antagonists in inhibition of melanization was done clinically and histochemically using Fontana Masson and DOPA reactions compared with placebo. Results: The post-irradiation pigmentation was found to be brownish/black instead of the original light brown color. This color change occurred below the shaved orange-red fur suggesting a switch of melanogenesis from pheomelanin to eumelanin. The induced pigmentation was suppressed by topically applied H 2 antagonist while both H 1 antagonist and vehicle had no effect. The microscopic examination showed that the keratinocytes in the H 2 antagonist-treated areas contained few melanosomes while the nearby dendrites are full of them. Conclusion: H 2 antagonists' inhibition of UVB-induced pigmentation is not only due to suppression of melanization but also due to a specific action on melanosomes' transfer.


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Online since 15th March '04
Published by Wolters Kluwer - Medknow