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Year : 2010  |  Volume : 76  |  Issue : 1  |  Page : 56--58

Lichen sclerosus: Role of occlusion of the genital skin in the pathogenesis

1 Department of Dermatology and Venereology, All India Institute of Medical Sciences New Delhi - 110 029, India
2 Postgraduate Institute of Medical Education and Research, Chandigarh, India

Correspondence Address:
Somesh Gupta
Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi - 110 029
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0378-6323.58681

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Lichen sclerosus (LS) is a chronic inflammatory skin disease, which most commonly involves the anogenital region. The etiology of LS is obscure, but genetic susceptibility, autoimmune mechanisms, infective agents like human papillomavirus and spirochaetes, and Koebner phenomenon has been postulated as causative factors. We report our observation in 6 patients (3 males and 3 females) with histologically proven lichen sclerosus that showed relative sparing of the uncovered areas of the genitals, thereby suggesting that the occlusion of the genital skin may be playing a greater role in the causation of LS than is currently thought, in both sexes.


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Online since 15th March '04
Published by Wolters Kluwer - Medknow