|
| ORIGINAL ARTICLE |
|
|
|
| Year : 2009 | Volume
: 75
| Issue : 6 | Page : 579-582 |
Association of HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome among Indians
Timir Y Mehta1, Laxman M Prajapati2, Bharti Mittal3, Chaitanya G Joshi4, Jayesh J Sheth5, Dinesh B Patel6, Dinkar M Dave1, Ramesh K Goyal7
1 Dr. Rasiklal Shah Sarvajanik Hospital, Modasa 383315, India
2 Shri B. M. Shah College of Pharmaceutical Education and Research, Modasa 383315, India
3 Department of Molecular Biology, Krishna Institute of Medical Sciences, Hyderabad 500003, India
4 Deparment of Animal Biotechnology, Anand Agricultural University, Anand 388001, India
5 Institute of Human Genetics, Ahmedabad 380015, India
6 Deep Hospital, Modasa 383315, India
7 Department of Pharmacology, L M College of Pharmacy, Ahmedabad 380009, India
| Date of Web Publication | 12-Nov-2009 |
Correspondence Address:
Timir Y Mehta
Dr. Rasiklal Shah Sarvajanik Hospital, Modasa - 383 315, Gujarat
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0378-6323.57718
Background: Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis are severe cutaneous reactions caused by certain drugs, including antiepileptic carbamazepine. A strong association has been reported between human leucocyte antigen (HLA)-B*1502 and carbamazepine-induced SJS in Han Chinese patients. European studies suggested that HLA-B*1502 is not a universal marker but is ethnicity-specific for Asians. Aim: To study the association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients. Methods: Eight individuals who fulfilled the diagnostic criteria of SJS induced by carbamazepine were identified and HLA-B molecular typing was performed. HLA-B genotyping was carried out by polymerase chain reaction using sequence-specific primers. Results: Out of eight patients studied for genotype, six patients were found to have the HLA-B*1502 allele. Conclusion: This study suggests an association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients.
Keywords: Carbamazepine, HLA-BFNx011502, Hindu, Indian, Stevens-Johnson syndrome
How to cite this article:
Mehta TY, Prajapati LM, Mittal B, Joshi CG, Sheth JJ, Patel DB, Dave DM, Goyal RK. Association of HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome among Indians. Indian J Dermatol Venereol Leprol 2009;75:579-82 |
How to cite this URL:
Mehta TY, Prajapati LM, Mittal B, Joshi CG, Sheth JJ, Patel DB, Dave DM, Goyal RK. Association of HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome among Indians. Indian J Dermatol Venereol Leprol [serial online] 2009 [cited 2020 Oct 31];75:579-82. Available from: https://www.ijdvl.com/text.asp?2009/75/6/579/57718 |
| Introduction | |  |
Stevens-Johnson syndrome More Details (SJS) and toxic epidermal necrolysis (TEN) are acute life-threatening reactions of the skin to drugs. SJS and TEN are two related mucocutaneous blistering disorders with significant mortality (especially with TEN) and prolonged morbidity. Patients develop an acute exanthema, which progresses toward a widespread blistering (TEN) or more limited purpura, vesicles (SJS) and erosion of the skin and mucous membranes, resulting from apoptosis of keratinocytes. The incidence of SJS is estimated to be one to six cases per million person-years and of TEN at 0.4-1.2 cases per million person-years. Various drugs are reported to be associated with a high risk for SJS and TEN. These include several antiepileptic agents, especially carbamazepine, phenytoin, phenobarbital and lamotrigine, antibacterials, anti-inflammatory drugs of the oxicam family and allopurinol. [1],[2]
Chung and colleagues [3] reported a very strong association between carbamazepine-induced SJS in Han Chinese patients and the human leucocyte antigen (HLA)-B*1502 allele. They studied 44 Han Chinese patients with carbamazepine-induced SJS and two groups of controls, 101 tolerant patients and 93 healthy controls. All 44 SJS or TEN patients had an HLA-B*1502 allele in contrast with 3% of the carbamazepine-tolerant patients and 8.6% of the unexposed controls, respectively. [3] In Europe, HLA-B genotyping was carried out in 12 patients of carbamazepine-induced SJS. Of the 12, only four had HLA-B*1502. Remarkably, all the four had an Asian ancestry and originated from China, Vietnam, Cambodia, and the Reunion Island. It was suggested that HLA-B*1502 is not a universal marker for carbamazepine-induced SJS but is ethnicity-specific for Asians. [4] Studies in other Asian populations from Malaysia, Thailand and Hong Kong have also reported an association between HLA-B*1502 and SJS induced by carbamazepine. [5],[6],[7] None of these studies have been reported from India although the incidences of SJS were found to be higher among Indians compared with Europeans. [8],[9],[10],[11] Carbamazepine is a widely prescribed antiepileptic in India and is found to be the most commonly implicated drug responsible for SJS/TEN among Indians. [12] In the light of the above observations, we have undertaken an HLA genotyping study of Indian patients suffering from carbamazepine-induced SJS.
| Methods | | |
Patient recruitment and sample collection
Eight individuals who fulfilled the diagnostic criteria of SJS induced by carbamazepine were identified at Dr. Rasiklal Shah Sarvajanik Hospital and Samarpan Centre for Treatment of Diseases of Skin, STD and Leprosy, Modasa, India. All the patients were assessed by dermatologists who had received photographs, pathological slides and medical records. Patients with definite diagnosis and ready to sign written consent were included in the study. Ten unrelated normal controls from the same population were selected randomly. The study was approved by the Institutional Review Board of Dr. Rasiklal Shah Sarvajanik Hospital, Modasa. The diagnostic criteria of SJS were based on the clinical morphology defined by Roujeau. [13] We defined SJS as skin detachment up to 10% of the body surface area and overlap SJS/TEN as skin detachment of 10-30%. Our five patients (no. 2, 3, 4, 7, 8) received carbamazepine as an antiepileptic therapy. Two patients (no. 5, 6) received carbamazepine as a post head injury anticonvulsant prophylaxis. In the remaining one patient (no. 1), trigeminal neuralgia was the indication for carbamazepine. Peripheral blood was collected in ethylene diammine tetra acetic acid-coated sterile vials and stored in a refrigerator. [Table 1] shows the clinical characteristics of eight patients with carbamazepine-induced SJS identified in our study.
DNA extraction
Genomic DNA from peripheral lymphocytes was extracted by the standard phenol-chloroform method.
HLA-B genotyping
The quality and quantity of the extracted DNA was checked on 0.8% agarose gel and a spectrophotometer. The concentration of each DNA sample was finally adjusted to 30 ng/µl, which was used for HLA-B molecular typing. HLA-B genotyping was carried out by polymerase chain reaction (PCR) using sequence-specific primers (Micro SSP HLA-B kits; One Lambda Inc., Canoga Park, CA, United States. Low-resolution HLA-B genotyping was carried out with the One Lambda HLA-B kit in a PCR with sequence-specific primers according to the protocol and recommendations of the manufacturer (PCR-SSP, One Lambda Inc.).
Statistical analysis
Allele frequency between the two groups was compared by the Chi-square method with Yates' correction by constructing 2 x 2 tables. The odds ratio was calculated with Haldane's modification, which adds 0.5 to all cells to accommodate a possible zero count.
| Results | | |
We determined the HLA-B genotypes of eight carbamazepine-induced cases and 10 normal controls by PCR using sequence-specific primers (Micro SSP HLA-B kits; One Lambda Inc.). We found that six out of eight patients had the HLA-B*1502 allele (all being heterozygous). One patient was found to be homozygous with HLA-B*1508 allele. All the 10 controls were found to be negative for HLA-B*1502. The genotypes observed are shown in [Table 2]. The odds ratio was found to be 71.40 (95% CI, 3.0-1698) and the P-value was found to be 0.0014.
| Discussion | | |
HLA-B*1502 as a marker for carbamazepine-induced SJS is well established in the Han Chinese by different studies. The allele frequency of HLA-B*1502 in the Han Chinese population is 8%, which is relatively higher than any other population of the world. [14] From India, a 0-6% (average 2.5%) prevalence of HLA-B*1502 in different communities has been reported. Most of them are sub-Hindu communities, except Parsi, in which a 0% prevalence is reported. [15],[16],[17],[18],[19],[20] Our eight patients also belong to the Hindu community, which is the biggest community of India comprising of one billion Indians. Our six out of eight patients had HLA-B*1502 while none of the 10 controls were found to be positive. This clearly indicates a significant association (Odds ratio: 71.40 [95% CI, 3.0-1698]; P = 0.0014) between carbamazepine-induced SJS and HLA-B*1502 among Indians.
Because the association is not 100%, as observed in the Han Chinese community, other genes or combinations of genes might be playing a role. To conclude, we suggest HLA-B*1502 testing before initiating carbamazepine drug therapy in Indians. To obtain a clear Indian picture, the study should be extended to different subethnic groups from different regions.
| References | | |
| 1. | Bastuji-Garin S, Rzany B, Stern RS, Shear NH, Naldi L, Roujeau JC. Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme. Arch Dermatol 1993;129:92-6.  [PUBMED] [FULLTEXT] |
| 2. | Roujeau JC, Kelly JP, Naldi L, Rzany B, Stern RS, Anderson T, et al. Medication use and risk of Stevens-Johnson syndrome or toxic epidermal necrolysis. New Engl J Med 1995;333:1600-7. [PUBMED] [FULLTEXT] |
| 3. | Chung WH, Hung SI, Hong HS, Hsih MS, Yang LC, Ho HC, et al. A marker for Stevens-Johnson syndrome. Nature 2004;428:86. |
| 4. | Lonjou C, Thomas L, Borot N, Ledger N, de Toma C, LeLouet H, et al. A marker for Stevens-Johnson syndrome: Ethnicity matters. Pharmacogenomics J 2006;6:265-8. [PUBMED] [FULLTEXT] |
| 5. | Chang CC, Too CL, Murad S, Hussein S. Association of HLA-B*1502 with carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome in Malaysian population. Proceeding in 7th Asian- Oceanian Epilepsy Congress, Xiamen. 2008. |
| 6. | Locharernkul C, Loplumlert J, Limotai C, Korkij W, Desudchit T, Tongkobpetch S, et al. Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai population. Epilepsia 2008;49:2087-91. [PUBMED] [FULLTEXT] |
| 7. | Man CB, Kwan P, Baum L, Yu E, Lau KM, Cheng AS, et al. Association between HLA-B*1502 Allele and antiepileptic drug-induced cutaneous reactions in Han Chinese. Epilepsia 2007;48:1015-8. [PUBMED] [FULLTEXT] |
| 8. | Uppal R, Jhaj R, Malhotra S. Adverse drug reactions among inpatients in a North Indian referral hospital. Natl Med J India 2000;13:16-8. [PUBMED] [FULLTEXT] |
| 9. | Naldi L, Conforti A, Venegoni M, Troncon MG, Caputi A, Ghiotto E, et al. Cutaneous reactions to drugs. An analysis of spontaneous reports in four Italian regions. Br J Clin Pharmacol 1999;48:839-46. |
| 10. | Hunziker T, Künzi UP, Braunschweig S, Zehnder D, Hoigné R. Comprehensive hospital drug monitoring (CHDM): Adverse skin reactions, a 20-year survey. Allergy 1997;52:388-93. |
| 11. | Noel MV, Sushma M, Guido S. Cutaneous adverse drug reactions in hospitalized patients in a tertiary care center. Indian J Pharmacol 2004;36:292-5.  |
| 12. | Devi K, George S, Criton S, Suja V, Sridevi PK. Carbamazepine - The commonest cause of toxic epidermal necrolysis and Stevens-Johnson syndrome: A study of 7 years. Indian J Dermatol Venereol Leprol 2005;71:325-8. [PUBMED] |
| 13. | Roujeau JC. The spectrum of Stevens-Johnson syndrome and toxic epidermal necrolysis: A clinical classification. J Invest Dermatol 1994;102:28-30. |
| 14. | Geer L, Terasaki PI, Gjertson DW. HLA frequency. In: Gjertson DW, Terasaki PI, editors. HLA 1998. Lenexa, KS: American Society for Histocompatibility and Immunogenetics; 1998. p. 327-63. |
| 15. | Shankarkumar U. HLA-A, -B and -Cw allele frequencies in a Bhil population from Western India. Hum Immunol 2004;65:960-61. |
| 16. | Shankarkumar U. HLA-A, -B and -Cw allele frequencies in a Maratha population from Mumbai, India India Mumbai Marathas. Hum Immunol 2004;65:954-6. |
| 17. | Shankarkumar U. HLA-A, -B and -Cw allele frequencies in a Pawra population from Khandesh, India. Hum Immunol 2004;65:952-53. |
| 18. | Shankarkumar U. HLA-A, -B and -Cw allele frequencies in a Parsi population from Western India. Hum Immunol 2004;65:992-93. |
| 19. | Rajalingam R, Parham P, Mehra NK. HLA-A, -B, -Cw, -DQA1, -DQB1 and -DRB1 Alleles and KIR Alleles in a Hindu Population from Punjab, India. Hum Immunol 2004;65:958-60. |
| 20. | Rani R, Marcos C, Lazaro AM, Zhang Y, Stastny P. Molecular diversity of HLA-A, -B and -C alleles in a North Indian population as determined by PCR-SSOP. Int J Immunogenet 2007;34:201-8. [PUBMED] [FULLTEXT] |
[Table 1], [Table 2]
| This article has been cited by | | 1 |
Role of dermatology in pharmacogenomics: drug-induced skin injury |
|
| Riccardo G Borroni | | Pharmacogenomics. 2015; 16(4): 401 | | [Pubmed] | [DOI] | | | 2 |
Upregulated RIP3 Expression Potentiates MLKL Phosphorylation–Mediated Programmed Necrosis in Toxic Epidermal Necrolysis |
|
| Sue Kyung Kim,Woo-Jung Kim,Jung-Ho Yoon,Jae-Hoon Ji,Michael J Morgan,Hyeseong Cho,You Chan Kim,You-Sun Kim | | Journal of Investigative Dermatology. 2015; | | [Pubmed] | [DOI] | | | 3 |
PharmGKB summary |
|
| Julia M. Barbarino,Deanna L. Kroetz,Teri E. Klein,Russ B. Altman | | Pharmacogenetics and Genomics. 2015; 25(4): 205 | | [Pubmed] | [DOI] | | | 4 |
New genetic findings lead the way to a better understanding of fundamental mechanisms of drug hypersensitivity |
|
| Munir Pirmohamed,David A. Ostrov,B. Kevin Park | | Journal of Allergy and Clinical Immunology. 2015; 136(2): 236 | | [Pubmed] | [DOI] | | | 5 |
Research on Susceptible Genes and Immunological Pathogenesis of Cutaneous Adverse Drug Reactions in Chinese Hans |
|
| Fangping Yang,Ying Yang,Qinyuan Zhu,Sheng-an Chen,Xiaodan Fu,Sijia Yan,Chunjie Meng,Li Ma,Xinfen Sun,Jinhua Xu,Xiaoqun Luo,Qinghe Xing | | Journal of Investigative Dermatology Symposium Proceedings. 2015; 17(1): 29 | | [Pubmed] | [DOI] | | | 6 |
Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: An Update |
|
| Roni P. Dodiuk-Gad,Wen-Hung Chung,Laurence Valeyrie-Allanore,Neil H. Shear | | American Journal of Clinical Dermatology. 2015; 16(6): 475 | | [Pubmed] | [DOI] | | | 7 |
Stevens–Johnson syndrome and toxic epidermal necrolysis: an update on pharmacogenetics studies in drug-induced severe skin reaction |
|
| Sara Rufini,Cinzia Ciccacci,Cristina Politi,Emiliano Giardina,Giuseppe Novelli,Paola Borgiani | | Pharmacogenomics. 2015; 16(17): 1989 | | [Pubmed] | [DOI] | | | 8 |
HLA-B*1502 and carbamazepine-induced severe cutaneous adverse drug reactions in Vietnamese |
|
| Dinh Van Nguyen,Hieu Chi Chu,Doan Van Nguyen,Minh Hong Phan,Timothy Craig,Karl Baumgart,Sheryl van Nunen | | Asia Pacific Allergy. 2015; 5(2): 68 | | [Pubmed] | [DOI] | | | 9 |
GWAS identifies two susceptibility loci for lamotrigine-induced skin rash in patients with epilepsy |
|
| Hui Won Jang,So Won Kim,Yang-Je Cho,Kyoung Heo,Byung In Lee,Sang Kun Lee,In-Jin Jang,Min Goo Lee,Won-Joo Kim,Ji Hyun Lee | | Epilepsy Research. 2015; 115: 88 | | [Pubmed] | [DOI] | | | 10 |
Evolving models of the immunopathogenesis of T cell–mediated drug allergy: The role of host, pathogens, and drug response |
|
| Katie D. White,Wen-Hung Chung,Shuen-Iu Hung,Simon Mallal,Elizabeth J. Phillips | | Journal of Allergy and Clinical Immunology. 2015; 136(2): 219 | | [Pubmed] | [DOI] | | | 11 |
Genetic screening for human leukocyte antigen alleles prior to carbamazepine treatment |
|
| Jeremy C.K. Tan,Dedee F. Murrell,Mark I. Hersch | | Journal of Clinical Neuroscience. 2015; 22(12): 1992 | | [Pubmed] | [DOI] | | | 12 |
Recent advances of pharmacogenomics in severe cutaneous adverse reactions: immune and nonimmune mechanisms |
|
| Ro-Lan Dao,Shih-Chi Su,Wen-Hung Chung | | Asia Pacific Allergy. 2015; 5(2): 59 | | [Pubmed] | [DOI] | | | 13 |
Identification of Stevens-Johnson syndrome and toxic epidermal necrolysis in electronic health record databases |
|
| Robert L. Davis,Mia A. Gallagher,Maryam M. Asgari,Melody J. Eide,David J. Margolis,Eric Macy,James K. Burmester,Nandini Selvam,Joseph A. Boscarino,Lee F. Cromwell,Heather S. Feigelson,Jennifer L. Kuntz,Pamala A. Pawloski,Robert B. Penfold,Marsha A. Raebel,Gayathri Sridhar,Ann Wu,Lois A. La Grenade,Michael A. Pacanowski,Simone P. Pinheiro | | Pharmacoepidemiology and Drug Safety. 2015; 24(7): 684 | | [Pubmed] | [DOI] | | | 14 |
Fever, Rash, and Systemic Symptoms: Understanding the Role of Virus and HLA in Severe Cutaneous Drug Allergy |
|
| Rebecca Pavlos,Simon Mallal,David Ostrov,Yuri Pompeu,Elizabeth Phillips | | The Journal of Allergy and Clinical Immunology: In Practice. 2014; 2(1): 21 | | [Pubmed] | [DOI] | | | 15 |
Recommendations for HLA-B*15:02 and HLA-A*31:01 genetic testing to reduce the risk of carbamazepine-induced hypersensitivity reactions |
|
| Ursula Amstutz,Neil H. Shear,Michael J. Rieder,Soomi Hwang,Vincent Fung,Hidefumi Nakamura,Mary B. Connolly,Shinya Ito,Bruce C. Carleton | | Epilepsia. 2014; : n/a | | [Pubmed] | [DOI] | | | 16 |
Genetics of Immune-Mediated Adverse Drug Reactions: a Comprehensive and Clinical Review |
|
| V. L. M. Yip,A. Alfirevic,M. Pirmohamed | | Clinical Reviews in Allergy & Immunology. 2014; | | [Pubmed] | [DOI] | | | 17 |
Association of carbamazepine-induced severe cutaneous drug reactions and HLA-B*1502 allele status, and dose and treatment duration in paediatric neurology patients in Singapore |
|
| K. W. Chong,D. W. S. Chan,Y. B. Cheung,L. K. Ching,S. L. Hie,T. Thomas,S. Ling,E. C. Tan | | Archives of Disease in Childhood. 2014; 99(6): 581 | | [Pubmed] | [DOI] | | | 18 |
Association of HLA-B*1502 and *1511 allele with antiepileptic drug-induced Stevens-Johnson syndrome in central China |
|
| Dan Sun,Chun-hua Yu,Zhi-sheng Liu,Xue-lian He,Jia-sheng Hu,Ge-fei Wu,Bing Mao,Shu-hua Wu,Hui-hui Xiang | | Journal of Huazhong University of Science and Technology [Medical Sciences]. 2014; 34(1): 146 | | [Pubmed] | [DOI] | | | 19 |
Digging Up the Human Genome: Current Progress in Deciphering Adverse Drug Reactions |
|
| Shih-Chi Su,Wen-Hung Chung,Shuen-Iu Hung | | BioMed Research International. 2014; 2014: 1 | | [Pubmed] | [DOI] | | | 20 |
Building pharmacogenetics into a pharmacovigilance program in Singapore: using serious skin rash as a pilot study |
|
| D S L Toh,L L Tan,D C W Aw,S M Pang,S H Lim,T Thirumoorthy,H Y Lee,Y K Tay,S K Tan,A Vasudevan,A Lateef,Y Y Chong,Y C Chan,C Loke,C L Chan,E S C Koay,E C Ren,E J D Lee,C Sung | | The Pharmacogenomics Journal. 2014; | | [Pubmed] | [DOI] | | | 21 |
International Consensus on drug allergy |
|
| P. Demoly,N. F. Adkinson,K. Brockow,M. Castells,A. M. Chiriac,P. A. Greenberger,D. A. Khan,D. M. Lang,H.-S. Park,W. Pichler,M. Sanchez-Borges,T. Shiohara,B. Y.-H. Thong | | Allergy. 2014; 69(4): 420 | | [Pubmed] | [DOI] | | | 22 |
Ancestry-based pharmacogenomics, adverse reactions and carbamazepine: is the FDA warning correct? |
|
| P W Payne | | The Pharmacogenomics Journal. 2014; | | [Pubmed] | [DOI] | | | 23 |
Association ofHLA-B*1502allele with lamotrigine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Han Chinese subjects: a meta-analysis |
|
| Tao Zeng,Yue-Sheng Long,Fu-Li Min,Wei-Ping Liao,Yi-Wu Shi | | International Journal of Dermatology. 2014; : n/a | | [Pubmed] | [DOI] | | | 24 |
Antiepileptic drugs and adverse skin reactions: An update |
|
| Barbara Blaszczyk,Wladyslaw Lason,Stanislaw Jerzy Czuczwar | | Pharmacological Reports. 2014; | | [Pubmed] | [DOI] | | | 25 |
HLA-B*1502 is associated with carbamazepine induced Stevens–Johnson syndrome in North Indian population |
|
| Ritu Aggarwal,Madhulika Sharma,Manish Modi,Vivek kumar Garg,Manilla Salaria | | Human Immunology. 2014; 75(11): 1120 | | [Pubmed] | [DOI] | | | 26 |
Clinical features of and genetic predisposition to drug-induced Stevens–Johnson syndrome and toxic epidermal necrolysis in a single Korean tertiary institution patients—investigating the relation between the HLA -B*4403 allele and lamotrigine |
|
| Hye Jung Park,Sung Ryeol Kim,Dong Woo Leem,Il Joo Moon,Beom Seok Koh,Kyung Hee Park,Jung-Won Park,Jae-Hyun Lee | | European Journal of Clinical Pharmacology. 2014; | | [Pubmed] | [DOI] | | | 27 |
HLA-B*15:02 association with carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in an Indian population: a pooled-data analysis and meta-analysis |
|
| Amy Hui-Ping Khor,Kheng-Seang Lim,Chong-Tin Tan,Su-Ming Wong,Ching-Ching Ng | | Epilepsia. 2014; : n/a | | [Pubmed] | [DOI] | | | 28 |
Personalized Pharmacogenomics: Predicting Efficacy and Adverse Drug Reactions |
|
| Munir Pirmohamed | | Annual Review of Genomics and Human Genetics. 2014; 15(1): 349 | | [Pubmed] | [DOI] | | | 29 |
Pharmacogenetics of antiepileptic drug-induced hypersensitivity |
|
| Katarzyna M Bloch,Graeme J Sills,Munir Pirmohamed,Ana Alfirevic | | Pharmacogenomics. 2014; 15(6): 857 | | [Pubmed] | [DOI] | | | 30 |
Genetic predictors of Stevens–Johnson syndrome and toxic epidermal necrolysis induced by aromatic antiepileptic drugs among the Chinese Han population |
|
| Wei Wang,Fa-Yun Hu,Xin-Tong Wu,Dong-Mei An,Bo Yan,Dong Zhou | | Epilepsy & Behavior. 2014; 37: 16 | | [Pubmed] | [DOI] | | | 31 |
Rapid detection ofHLA-A*31:01allele in DNA and blood samples using loop-mediated isothermal amplification |
|
| Y.K. Cheung,M. Kwok,E. Chan,P. Kwan | | British Journal of Dermatology. 2014; : n/a | | [Pubmed] | [DOI] | | | 32 |
Genotyping for Severe Drug Hypersensitivity |
|
| Eric Karlin,Elizabeth Phillips | | Current Allergy and Asthma Reports. 2014; 14(3) | | [Pubmed] | [DOI] | | | 33 |
Hypersensitivity to Antiepileptic Drugs |
|
| Young-Min Ye,Bernard Yu-Hor Thong,Hae-Sim Park | | Immunology and Allergy Clinics of North America. 2014; | | [Pubmed] | [DOI] | | | 34 |
Pharmacogenetics: a reality or misplaced optimism? |
|
| S. MUTSATSA,T. J. CURRID | | Journal of Psychiatric and Mental Health Nursing. 2013; 20(4): 314 | | [Pubmed] | [DOI] | | | 35 |
Human leukocyte antigen-associated drug hypersensitivity |
|
| Patricia T Illing,Julian P Vivian,Anthony W Purcell,Jamie Rossjohn,James McCluskey | | Current Opinion in Immunology. 2013; 25(1): 81 | | [Pubmed] | [DOI] | | | 36 |
Development of a Simple Method for Detection of the HLA-A*31:01 Allele |
|
| Kazuki UCHIYAMA,Fumika KUBOTA,Noritaka ARIYOSHI,Jun MATSUMOTO,Itsuko ISHII,Mitsukazu KITADA | | Drug Metabolism and Pharmacokinetics. 2013; 28(5): 435 | | [Pubmed] | [DOI] | | | 37 |
Stevens-Johnson syndrome / toxic epidermal necrolysis: an Asia-Pacific perspective |
|
| Bernard Yu-Hor Thong | | Asia Pacific Allergy. 2013; 3(4): 215 | | [Pubmed] | [DOI] | | | 38 |
Toxic epidermal necrolysis |
|
| Robert A. Schwartz,Patrick H. McDonough,Brian W. Lee | | Journal of the American Academy of Dermatology. 2013; 69(2): 173.e1 | | [Pubmed] | [DOI] | | | 39 |
Update on pathobiology in Stevens-Johnson syndrome and toxic epidermal necrolysis |
|
| Shih-Chi Su,Wen-Hung Chung | | Dermatologica Sinica. 2013; 31(4): 175 | | [Pubmed] | [DOI] | | | 40 |
Pharmacogenomics of severe cutaneous adverse reactions and drug-induced liver injury |
|
| Nahoko Kaniwa,Yoshiro Saito | | Journal of Human Genetics. 2013; 58(6): 317 | | [Pubmed] | [DOI] | | | 41 |
Proton pump inhibitors are associated with hypersensitivity reactions to drugs in hospitalized patients: a nested case-control in a retrospective cohort study |
|
| E. Ramírez,R. Cabañas,L. S. Laserna,A. Fiandor,H. Tong,N. Prior,O. Calderón,N. Medrano,I. Bobolea,J. Frías,S. Quirce | | Clinical & Experimental Allergy. 2013; 43(3): 344 | | [Pubmed] | [DOI] | | | 42 |
Toxic epidermal necrolysis |
|
| Haur-Yueh Lee,Wen-Hung Chung | | Current Opinion in Allergy and Clinical Immunology. 2013; : 1 | | [Pubmed] | [DOI] | | | 43 |
Clinical Pharmacogenetics Implementation Consortium Guidelines for HLA-B Genotype and Carbamazepine Dosing |
|
| S G Leckband,J R Kelsoe,H M Dunnenberger,A L George,E Tran,R Berger,D J Müller,M Whirl-Carrillo,K E Caudle,M Pirmohamed | | Clinical Pharmacology & Therapeutics. 2013; 94(3): 324 | | [Pubmed] | [DOI] | | | 44 |
HLA-B alleles associated with severe cutaneous reactions to antiepileptic drugs in Han Chinese |
|
| Ying-Kit Cheung,Suk-Hang Cheng,Ernest J. M. Chan,Su V. Lo,Margaret H. L. Ng,Patrick Kwan | | Epilepsia. 2013; 54(7): 1307 | | [Pubmed] | [DOI] | | | 45 |
Pharmacogenomics of severe cutaneous adverse reactions |
|
| Nahoko Kaniwa,Yoshiro Saito | | Pharmacogenomics. 2013; 14(6): 595 | | [Pubmed] | [DOI] | | | 46 |
HLA-A*31:01 and different types of carbamazepine-induced severe cutaneous adverse reactions: an international study and meta-analysis |
|
| E Genin,D-P Chen,S-I Hung,P Sekula,M Schumacher,P-Y Chang,S-H Tsai,T-L Wu,T Bellón,R Tamouza,C Fortier,A Toubert,D Charron,A Hovnanian,P Wolkenstein,W-H Chung,M Mockenhaupt,J-C Roujeau | | The Pharmacogenomics Journal. 2013; | | [Pubmed] | [DOI] | | | 47 |
Simple and rapid detection of HLA-A*31:01 for prediction of carbamazepine-induced hypersensitivity using loop-mediated isothermal amplification method |
|
| Hiroyuki NIIHARA,Kunie KOHNO,Takeshi TAKETANI,Sakae KANEKO,Takahumi ITO,Takashi SUGAMORI,Nobuyuki TAKAHASHI,Tuyoshi MIYAOKA,Shihoh OKAZAKI,Hideaki YASUDA,Motohide FURUYA,Michiharu NAGAHAMA,Eishin MORITA | | Journal of Dermatological Science. 2013; | | [Pubmed] | [DOI] | | | 48 |
Specific HLA types are associated with antiepileptic drug-induced Stevens–Johnson syndrome and toxic epidermal necrolysis in Japanese subjects |
|
| Nahoko Kaniwa,Emiko Sugiyama,Yoshiro Saito,Kouichi Kurose,Keiko Maekawa,Ryuichi Hasegawa,Hirokazu Furuya,Hiroko Ikeda,Yukitoshi Takahashi,Masaaki Muramatsu,Masahiro Tohkin,Takeshi Ozeki,Taisei Mushiroda,Michiaki Kubo,Naoyuki Kamatani,Masamichi Abe,Akiko Yagami,Mayumi Ueta,Chie Sotozono,Shigeru Kinoshita,Zenro Ikezawa,Kayoko Matsunaga,Michiko Aihara | | Pharmacogenomics. 2013; 14(15): 1821 | | [Pubmed] | [DOI] | | | 49 |
HLA-A*31:01 and HLA-B*15:02 as Genetic Markers for Carbamazepine Hypersensitivity in Children |
|
| U Amstutz,C J D Ross,L I Castro-Pastrana,M J Rieder,N H Shear,M R Hayden,B C Carleton | | Clinical Pharmacology & Therapeutics. 2013; 94(1): 142 | | [Pubmed] | [DOI] | | | 50 |
Dermatologic Side Effects of Psychotropic Medications |
|
| Mario V. Mitkov,Ryan M. Trowbridge,Benjamin N. Lockshin,Jason P. Caplan | | Psychosomatics. 2013; | | [Pubmed] | [DOI] | | | 51 |
HLA and disease: guilt by association |
|
| W. M. Howell | | International Journal of Immunogenetics. 2013; : n/a | | [Pubmed] | [DOI] | | | 52 |
Genotype–phenotype association between HLA and carbamazepine-induced hypersensitivity reactions: Strength and clinical correlations |
|
| Yi-Hsin Hsiao,Rosaline Chung-Yee Hui,Tony Wu,Wan-Chun Chang,Mo-Song Hsih,Chih-Hsun Yang,Hsin-Chun Ho,Ya-Ging Chang,Ming-Jing Chen,Jing-Yi Lin,Ding-Ping Chen,Pi-Yueh Chang,Tsu-Lan Wu,Shuen-Iu Hung,Wen-Hung Chung | | Journal of Dermatological Science. 2013; | | [Pubmed] | [DOI] | | | 53 |
Association between the HLA-B*15:02 allele and carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in Han individuals of northeastern China |
|
| Xiao-Jing He,Ling-Yan Jian,Xiao-Lin He,Yan Wu,Yuan-Yuan Xu,Xiao-Jie Sun,Li-Yan Miao,Li-Mei Zhao | | Pharmacological Reports. 2013; 65(5): 1256 | | [Pubmed] | [DOI] | | | 54 |
Recent advances in the genetics and immunology of Stevens-Johnson syndrome and toxic epidermal necrosis |
|
| Wen-Hung Chung,Shuen-Iu Hung | | Journal of Dermatological Science. 2012; 66(3): 190 | | [Pubmed] | [DOI] | | | 55 |
Association between HLA and Stevens-Johnson Syndrome Induced by Carbamazepine in Southern Han Chinese: Genetic Markers besides B*1502? |
|
| Yi-Wu Shi,Fu-Li Min,Bin Qin,Xin Zou,Xiao-Rong Liu,Mei-Mei Gao,Qian Wang,Jue-Qian Zhou,Wei-Ping Liao | | Basic & Clinical Pharmacology & Toxicology. 2012; : n/a | | [Pubmed] | [DOI] | | | 56 |
A Review of Pharmacogenetics of Adverse Drug Reactions in Elderly People |
|
| Maurizio Cardelli,Francesca Marchegiani,Andrea Corsonello,Fabrizia Lattanzio,Mauro Provinciali | | Drug Safety. 2012; 35(S1): 3 | | [Pubmed] | [DOI] | | | 57 |
Genetic and immune predictors for hypersensitivity syndrome to antiepileptic drugs |
|
| Manuela G. Neuman,Lawrence Cohen,Radu M. Nanau,Paul A. Hwang | | Translational Research. 2012; 159(5): 397 | | [Pubmed] | [DOI] | | | 58 |
Using companion and coupled diagnostics within strategy to personalize targeted medicines |
|
| Donald RJ Singer,John Watkins | | Personalized Medicine. 2012; 9(7): 751 | | [Pubmed] | [DOI] | | | 59 |
HLA and pharmacogenetics of drug hypersensitivity |
|
| Rebecca Pavlos,Simon Mallal,Elizabeth Phillips | | Pharmacogenomics. 2012; 13(11): 1285 | | [Pubmed] | [DOI] | | | 60 |
Drug Hypersensitivity and Human Leukocyte Antigens of the Major Histocompatibility Complex |
|
| Mandvi Bharadwaj,Patricia Illing,Alex Theodossis,Anthony W. Purcell,Jamie Rossjohn,James McCluskey | | Annual Review of Pharmacology and Toxicology. 2012; 52(1): 401 | | [Pubmed] | [DOI] | | | 61 |
The structural basis of HLA-associated drug hypersensitivity syndromes |
|
| Yuri A. Pompeu,Jon D. Stewart,Simon Mallal,Elizabeth Phillips,Bjoern Peters,David A. Ostrov | | Immunological Reviews. 2012; 250(1): 158 | | [Pubmed] | [DOI] | | | 62 |
Pharmacogenetic screening to prevent carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome: a critical appraisal |
|
| K. Wu,N.J. Reynolds | | British Journal of Dermatology. 2012; 166(1): 7 | | [Pubmed] | [DOI] | | | 63 |
Genetic and immune predictors for hypersensitivity syndrome to antiepileptic drugs |
|
| Neuman, M.G., Cohen, L., Nanau, R.M., Hwang, P.A. | | Translational Research. 2012; 159(5): 397-406 | | [Pubmed] | | | 64 |
Combinatorial approach for predicting antiepileptic drug specific hypersensitivity |
|
| [No author name available] | | Pharmacogenomics. 2012; 13(5): 520-521 | | [Pubmed] | | | 65 |
HLA-B*1502 allele is associated with a cross-reactivity pattern of cutaneous adverse reactions to antiepileptic drugs |
|
| Wang, J., Zhang, J., Wu, X., Yu, P., Hong, Z. | | Journal of International Medical Research. 2012; 40(1): 377-382 | | [Pubmed] | | | 66 |
A recent update of pharmacogenomics in drug-induced severe skin reactions |
|
| Wei, C.-Y., Ko, T.-M., Shen, C.-Y., Chen, Y.-T. | | Drug Metabolism and Pharmacokinetics. 2012; 27(1): 132-141 | | [Pubmed] | | | 67 |
Genome-wide mapping for clinically relevant predictors of lamotrigine-and phenytoin-induced hypersensitivity reactions |
|
| McCormack, M., Urban, T.J., Shianna, K.V., Walley, N., Pandolfo, M., Depondt, C., Chaila, E., (...), Cavalleri, G.L. | | Pharmacogenomics. 2012; 13(4): 399-405 | | [Pubmed] | | | 68 |
Drug hypersensitivity and human leukocyte antigens of the major histocompatibility complex |
|
| Bharadwaj, M., Illing, P., Theodossis, A., Purcell, A.W., Rossjohn, J., McCluskey, J. | | Annual Review of Pharmacology and Toxicology. 2012; 52: 401-431 | | [Pubmed] | | | 69 |
HLA-B*1502 Strongly Predicts Carbamazepine-Induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Thai Patients with Neuropathic Pain |
|
| Kulkantrakorn, K., Tassaneeyakul, W., Tiamkao, S., Jantararoungtong, T., Prabmechai, N., Vannaprasaht, S., Chumworathayi, P., (...), Sritipsukho, P. | | Pain Practice. 2012; 12(3): 202-208 | | [Pubmed] | | | 70 |
Profile and pattern of Stevens-Johnson syndrome and toxic epidermal necrolysis in a general hospital in Singapore: Treatment outcomes |
|
| Tan, S.-K., Tay, Y.-K. | | Acta Dermato-Venereologica. 2012; 92(1): 62-66 | | [Pubmed] | | | 71 |
Pharmacogenetic screening to prevent carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome: A critical appraisal |
|
| Wu, K., Reynolds, N.J. | | British Journal of Dermatology. 2012; 166(1): 7-11 | | [Pubmed] | | | 72 |
Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions |
|
| Mark McCormack,Thomas J Urban,Kevin V Shianna,Nicole Walley,Massimo Pandolfo,Chantal Depondt,Elijah Chaila,Gerard D O’Conner,Dalia Kasperaviciute,Rodney A Radtke,Erin L Heinzen,Sanjay M Sisodiya,Norman Delanty,Gianpiero L Cavalleri | | Pharmacogenomics. 2012; 13(4): 399 | | [Pubmed] | [DOI] | | | 73 |
Research Highlights: Highlights from the latest articles on pharmacogenetic studies of antiepileptic drugs |
|
| Sandeep Grover,Ritushree Kukreti | | Pharmacogenomics. 2012; 13(5): 519 | | [Pubmed] | [DOI] | | | 74 |
Integration of Pharmacogenetics and Pharmacogenomics in Drug Development: Implications for Regulatory and Medical Decision Making in Pediatric Diseases |
|
| Chiara Piana,Linda Surh,Sabine Furst-Recktenwald,Achille Iolascon,Evelyne M. Jacqz-Aigrain,Ineke Jonker,Roberta Russo,Ron H.N. van Schaik,Judith Wessels,Oscar E. Della Pasqua | | The Journal of Clinical Pharmacology. 2012; 52(5): 704 | | [Pubmed] | [DOI] | | | 75 |
T-cell receptor and carbamazepine-induced Stevens–Johnson syndrome and toxic epidermal necrolysis: understanding a hypersensitivity reaction |
|
| Tai-Ming Ko,Yuan-Tsong Chen | | Expert Review of Clinical Immunology. 2012; 8(5): 467 | | [Pubmed] | [DOI] | | | 76 |
A Recent Update of Pharmacogenomics in Drug-induced Severe Skin Reactions |
|
| Chun-Yu WEI,Tai-Ming KO,Chen-Yang SHEN,Yuan-Tsong CHEN | | Drug Metabolism and Pharmacokinetics. 2012; 27(1): 132 | | [Pubmed] | [DOI] | | | 77 |
HLA-A31 strongly associates with carbamazepine-induced adverse drug reactions but not with carbamazepine-induced lymphocyte proliferation in a Japanese population |
|
| Hiroyuki NIIHARA,Takeyasu KAKAMU,Yasuyuki FUJITA,Sakae KANEKO,Eishin MORITA | | The Journal of Dermatology. 2012; 39(7): 594 | | [Pubmed] | [DOI] | | | 78 |
Severe drug eruptions revisited |
|
| Sebastien Calbo | | Immunologic Research. 2012; 53(1-3): 162 | | [Pubmed] | [DOI] | | | 79 |
HLA Genotype and Carbamazepine-Induced Cutaneous Adverse Drug Reactions: A Systematic Review |
|
| V L Yip,A G Marson,A L Jorgensen,M Pirmohamed,A Alfirevic | | Clinical Pharmacology & Therapeutics. 2012; 92(6): 757 | | [Pubmed] | [DOI] | | | 80 |
HLA-B*1502 Strongly Predicts Carbamazepine-Induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Thai Patients with Neuropathic Pain |
|
| Kongkiat Kulkantrakorn,Wichittra Tassaneeyakul,Somsak Tiamkao,Thawinee Jantararoungtong,Napat Prabmechai,Suda Vannaprasaht,Pansu Chumworathayi,Pei Chen,Paskorn Sritipsukho | | Pain Practice. 2012; 12(3): 202 | | [Pubmed] | [DOI] | | | 81 |
Direct interaction between HLA-B and carbamazepine activates T cells in patients with Stevens-Johnson syndrome |
|
| Chun-Yu Wei,Wen-Hung Chung,Hsiao-Wen Huang,Yuan-Tsong Chen,Shuen-Iu Hung | | Journal of Allergy and Clinical Immunology. 2012; 129(6): 1562 | | [Pubmed] | [DOI] | | | 82 |
Drug reaction with eosinophilia and systemic symptoms (DRESS): a clinical update and review of current thinking |
|
| S. A. Walsh,D. Creamer | | Clinical and Experimental Dermatology. 2011; 36(1): 6 | | [Pubmed] | [DOI] | | | 83 |
Carbamazepine-induced severe cutaneous adverse reactions and HLA genotypes in Koreans |
|
| Sae-Hoon Kim,Kyung Wha Lee,Woo-Jung Song,Sang-Heon Kim,Young-Koo Jee,Sang-Min Lee,Hye-Ryun Kang,Heung-Woo Park,Sang-Heon Cho,Seong-Ho Park,Kyung-Up Min,Yoon-Seok Chang | | Epilepsy Research. 2011; 97(1-2): 190 | | [Pubmed] | [DOI] | | | 84 |
Carbamazepine-Induced Toxic Effects and HLA-B*1502 Screening in Taiwan |
|
| Pei Chen,Juei-Jueng Lin,Chin-Song Lu,Cheung-Ter Ong,Peiyuan F. Hsieh,Chih-Chao Yang,Chih-Ta Tai,Shey-Lin Wu,Cheng-Hsien Lu,Yung-Chu Hsu,Hsiang-Yu Yu,Long-Sun Ro,Chung-Ta Lu,Chun-Che Chu,Jing-Jane Tsai,Yu-Hsiang Su,Sheng-Hsing Lan,Sheng-Feng Sung,Shu-Yi Lin,Hui-Ping Chuang,Li-Chen Huang,Ying-Ju Chen,Pei-Joung Tsai,Hung-Ting Liao,Yu-Hsuan Lin,Chien-Hsiun Chen,Wen-Hung Chung,Shuen-Iu Hung,Jer-Yuarn Wu,Chi-Feng Chang,Luke Chen,Yuan-Tsong Chen,Chen-Yang Shen | | New England Journal of Medicine. 2011; 364(12): 1126 | | [Pubmed] | [DOI] | | | 85 |
The Genetics of Antiepileptic Drug–Induced Skin Reactions |
|
| S Hakimian,J W Miller | | Clinical Pharmacology & Therapeutics. 2011; 89(6): 908 | | [Pubmed] | [DOI] | | | 86 |
Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome |
|
| Tai-Ming Ko,Wen-Hung Chung,Chun-Yu Wei,Han-Yu Shih,Jung-Kuei Chen,Chia-Hsien Lin,Yuan-Tsong Chen,Shuen-Iu Hung | | Journal of Allergy and Clinical Immunology. 2011; 128(6): 1266 | | [Pubmed] | [DOI] | | | 87 |
Pharmacogenetics of cutaneous adverse drug reactions |
|
| Michiko AIHARA | | The Journal of Dermatology. 2011; 38(3): 246 | | [Pubmed] | [DOI] | | | 88 |
Strong association between HLA-B*1502 and carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in mainland Han Chinese patients |
|
| Yan Zhang,Jin Wang,Li-Mei Zhao,Wei Peng,Guo-Qing Shen,Ling Xue,Xiao-Xian Zheng,Xiao-Jing HE,Chun-Yan Gong,Li-Yan Miao | | European Journal of Clinical Pharmacology. 2011; 67(9): 885 | | [Pubmed] | [DOI] | | | 89 |
HLA-A*3101 and Carbamazepine-Induced Hypersensitivity Reactions in Europeans |
|
| Mark McCormack,Ana Alfirevic,Stephane Bourgeois,John J. Farrell,Dalia Kasperaviciute,Mary Carrington,Graeme J. Sills,Tony Marson,Xiaoming Jia,Paul I.W. de Bakker,Krishna Chinthapalli,Mariam Molokhia,Michael R. Johnson,Gerard D. OæConnor,Elijah Chaila,Saud Alhusaini,Kevin V. Shianna,Rodney A. Radtke,Erin L. Heinzen,Nicole Walley,Massimo Pandolfo,Werner Pichler,B. Kevin Park,Chantal Depondt,Sanjay M. Sisodiya,David B. Goldstein,Panos Deloukas,Norman Delanty,Gianpiero L. Cavalleri,Munir Pirmohamed | | New England Journal of Medicine. 2011; 364(12): 1134 | | [Pubmed] | [DOI] | | | 90 |
PharmGKB summary |
|
| Caroline F. Thorn,Susan G. Leckband,John Kelsoe,J. Steven Leeder,Daniel J. Müller,Teri E. Klein,Russ B. Altman | | Pharmacogenetics and Genomics. 2011; 21(12): 906 | | [Pubmed] | [DOI] | | | 91 |
Analysis of Body Constitution of Fifty-two Patients with Stevens-Johnson Syndrome (SJS) Using Kampo Medical Questionnaires: Prediction of SJS based on Body Constitution Using Decision Tree |
|
| Shigeru OHSHIMA,Yukiko HATORI,Seiichi HONMA,Katsutoshi TERASAWA,Yukiya SAITOH,Daisuke KOBAYASHI | | YAKUGAKU ZASSHI. 2011; 131(5): 745 | | [Pubmed] | [DOI] | | | 92 |
Phenytoin-induced Stevens–Johnson syndrome with negative HLA-B*1502 allele in mainland China: Two cases |
|
| Fa-Yun Hu,Xin-Tong Wu,Dong-Mei An,Bo Yan,Hermann Stefan,Dong Zhou | | Seizure. 2011; 20(5): 431 | | [Pubmed] | [DOI] | | | 93 |
Pilot association study of oxcarbazepine-induced mild cutaneous adverse reactions with HLA-B*1502 allele in Chinese Han population |
|
| Fa-yun Hu,Xin-tong Wu,Dong-mei An,Bo Yan,Hermann Stefan,Dong Zhou | | Seizure. 2011; 20(2): 160 | | [Pubmed] | [DOI] | | | 94 |
Exploratory Study on Biomarkers Associated with Severe Cutaneous Adverse Reactions |
|
| Nahoko KANIWA | | YAKUGAKU ZASSHI. 2011; 131(2): 255 | | [Pubmed] | [DOI] | | | 95 |
Epidemiology and risk factors for drug allergy |
|
| Bernard Y-H. Thong,Teck-Choon Tan | | British Journal of Clinical Pharmacology. 2011; 71(5): 684 | | [Pubmed] | [DOI] | | | 96 |
Carbamazepine-induced Stevens-Johnson syndrome: Genetic predisposition of Asian patients | [Stevens-Johnson-syndrom unter carbamazepin: Genetische prädisposition asiatischer patienten] |
|
| Spindelegger, C., Konstantinidis, A., Kasper, S. | | Journal fur Neurologie, Neurochirurgie und Psychiatrie. 2011; 12(2): 176-178 | | [Pubmed] | | | 97 |
Carbamzepine-induced toxic epidermal necrolysis |
|
| Chowta, N.K., Chowta, M.N., Ramapuram, J., Kumar, P., Fazil, A. | | Indian Journal of Critical Care Medicine. 2011; 15(2): 123-125 | | [Pubmed] | | | 98 |
Phenotype Standardization for Immune-Mediated Drug-Induced Skin Injury |
|
| M Pirmohamed,P S Friedmann,M Molokhia,Y K Loke,C Smith,E Phillips,L La Grenade,B Carleton,M Papaluca-Amati,P Demoly,N H Shear | | Clinical Pharmacology & Therapeutics. 2011; 89(6): 896 | | [Pubmed] | [DOI] | | | 99 |
Toxic epidermal necrolysis and Stevens-Johnson syndrome: A review* |
|
| Roland Gerull,Mathias Nelle,Thomas Schaible | | Critical Care Medicine. 2011; 39(6): 1521 | | [Pubmed] | [DOI] | | | 100 |
Drug reaction with eosinophilia and systemic symptoms (DRESS): A clinical update and review of current thinking |
|
| Walsh, S.A., Creamer, D. | | Clinical and Experimental Dermatology. 2011; 36(1): 6-11 | | [Pubmed] | | | 101 |
Phenotype standardization for immune-mediated drug-induced skin injury |
|
| Pirmohamed, M., Friedmann, P.S., Molokhia, M., Loke, Y.K., Smith, C., Phillips, E., La Grenade, L., (...), Shear, N.H. | | Clinical Pharmacology and Therapeutics. 2011; 89(6): 896-901 | | [Pubmed] | | | 102 |
Analysis of body constitution of fifty-two patients with stevens-johnson syndrome (SJS) using kampo medical questionnaires: Prediction of SJS based on body constitution using decision tree |
|
| Ohshima, S., Hatori, Y., Honma, S., Terasawa, K., Saitoh, Y., Kobayashi, D. | | Yakugaku Zasshi. 2011; 131(5): 745-756 | | [Pubmed] | | | 103 |
Epidemiology and risk factors for drug allergy |
|
| Thong, B.Y.-H., Tan, T.-C. | | British Journal of Clinical Pharmacology. 2011; 71(5): 684-700 | | [Pubmed] | | | 104 |
HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans |
|
| McCormack, M., Alfirevic, A., Bourgeois, S., Farrell, J.J., Kasperavičiute, D., Carrington, M., Sills, G.J., (...), Pirmohamed, M. | | New England Journal of Medicine. 2011; 364(12): 1134-1143 | | [Pubmed] | | | 105 |
Carbamazepine-induced toxic effects and HLA-B*1502 screening in Taiwan |
|
| Chen, P., Lin, J.-J., Lu, C.-S., Ong, C.-T., Hsieh, P.F., Yang, C.-C., Tai, C.-T., (...), Shen, C.-Y. | | New England Journal of Medicine. 2011; 364(12): 1126-1133 | | [Pubmed] | | | 106 |
Pharmacogenetics of cutaneous adverse drug reactions |
|
| Aihara, M. | | Journal of Dermatology. 2011; 38(3): 246-254 | | [Pubmed] | | | 107 |
Pilot association study of oxcarbazepine-induced mild cutaneous adverse reactions with HLA-B*1502 allele in Chinese Han population |
|
| Hu, F.-Y., Wu, X.-T., An, D.-M., Yan, B., Stefan, H., Zhou, D. | | Seizure. 2011; 20(2): 160-162 | | [Pubmed] | | | 108 |
Drug hypersensitivity: Pharmacogenetics and clinical syndromes |
|
| Phillips, E.J., Chung, W.-H., Mockenhaupt, M., Roujeau, J.-C., Mallal, S.A. | | Journal of Allergy and Clinical Immunology. 2011; 127(3 sup): s60-s66 | | [Pubmed] | | | 109 |
Drug induced hypersensitivity and the HLA complex |
|
| Alfirevic, A., Pirmohamed, M. | | Pharmaceuticals. 2011; 4(1): 69-90 | | [Pubmed] | | | 110 |
Exploratory study on biomarkers associated with severe cutaneous adverse reactions |
|
| Kaniwa, N. | | Yakugaku Zasshi. 2011; 131(2): 255-261 | | [Pubmed] | | | 111 |
Do no harm-But first we need to know more: The case of adverse drug reactions with antiepileptic drugs |
|
| Singh, G. | | Neurology India. 2011; 59(1): 53-58 | | [Pubmed] | | | 112 |
Carbamazepine-induced severe cutaneous adverse reactions and HLA genotypes in Koreans |
|
| Kim, S.-H., Lee, K.W., Song, W.-J., Kim, S.-H., Jee, Y.-K., Lee, S.-M., Kang, H.-R., (...), Chang, Y.-S. | | Epilepsy Research. 2011; 97(1-2): 190-197 | | [Pubmed] | | | 113 |
Strong association between HLA-Bz.ast1502 and carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in mainland Han Chinese patients |
|
| Zhang, Y., Wang, J., Zhao, L.-M., Peng, W., Shen, G.-Q., Xue, L., Zheng, X.-X., (...), Miao, L.-Y. | | European Journal of Clinical Pharmacology. 2011; 67(9): 885-887 | | [Pubmed] | | | 114 |
Antiepileptic drugs |
|
| Zaccara, G., Tramacere, L. | | Side Effects of Drugs Annual. 2011; 33(1): 125-204 | | [Pubmed] | | | 115 |
Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome |
|
| Ko, T.-M., Chung, W.-H., Wei, C.-Y., Shih, H.-Y., Chen, J.-K., Lin, C.-H., Chen, Y.-T., Hung, S.-I. | | Journal of Allergy and Clinical Immunology. 2011; 128(6): 1266-1276 | | [Pubmed] | | | 116 |
PharmGKB summary: Carbamazepine pathway |
|
| Thorn, C.F., Leckband, S.G., Kelsoe, J., Steven Leeder, J., Müller, D.J., Klein, T.E., Altman, R.B. | | Pharmacogenetics and Genomics. 2011; 21(12): 906-910 | | [Pubmed] | | | 117 |
Phenytoin-induced Stevens-Johnson syndrome with negative HLA-B*1502 allele in mainland China: Two cases |
|
| Hu, F.-Y., Wu, X.-T., An, D.-M., Yan, B., Stefan, H., Zhou, D. | | Seizure. 2011; 20(5): 431-432 | | [Pubmed] | | | 118 |
The genetics of antiepileptic drug-induced skin reactions |
|
| Hakimian, S., Miller, J.W. | | Clinical Pharmacology and Therapeutics. 2011; 89(6): 908-910 | | [Pubmed] | | | 119 |
Toxic epidermal necrolysis and Stevens-Johnson syndrome: A review |
|
| Gerull, R., Nelle, M., Schaible, T. | | Critical Care Medicine. 2011; 39(6): 1521-1532 | | [Pubmed] | | | 120 |
Drug Induced Hypersensitivity and the HLA Complex |
|
| Ana Alfirevic,Munir Pirmohamed | | Pharmaceuticals. 2010; 4(1): 69 | | [Pubmed] | [DOI] | | | 121 |
Carbamazepine-induced Stevens-Johnson syndrome sparing the skin previously affected by herpes zoster infection in a patient with systemic lupus erythematosus: A reverse isotopic phenomenon |
|
| Tenea, D. | | Case Reports in Dermatology. 2010; 2(2): 140-145 | | [Pubmed] | | | 122 |
Association study of lamotrigine-induced cutaneous adverse reactions and HLA-B*1502 in a Han Chinese population |
|
| An, D.-M., Wu, X.-T., Hu, F.-Y., Yan, B., Stefan, H., Zhou, D. | | Epilepsy Research. 2010; 92(2-3): 226-230 | | [Pubmed] | | | 123 |
HLA-B*1511 is a risk factor for carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients |
|
| Kaniwa, N., Saito, Y., Aihara, M., Matsunaga, K., Tohkin, M., Kurose, K., Furuya, H., (...), Hasegawa, R. | | Epilepsia. 2010; 51(12): 2461-2465 | | [Pubmed] | | | 124 |
Genetic markers and danger signals in Stevens-Johnson syndrome and toxic epidermal necrolysis |
|
| Chung, W.-H., Hung, S.-I. | | Allergology International. 2010; 59(4): 325-332 | | [Pubmed] | | | 125 |
Association study of lamotrigine-induced cutaneous adverse reactions and HLA-B*1502 in a Han Chinese population |
|
| Dong-Mei An,Xin-Tong Wu,Fa-Yun Hu,Bo Yan,Hermann Stefan,Dong Zhou | | Epilepsy Research. 2010; 92(2-3): 226 | | [Pubmed] | [DOI] | | | 126 |
HLA-B*1511 is a risk factor for carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients |
|
| Nahoko Kaniwa,Yoshiro Saito,Michiko Aihara,Kayoko Matsunaga,Masahiro Tohkin,Kouichi Kurose,Hirokazu Furuya,Yukitoshi Takahashi,Masaaki Muramatsu,Shigeru Kinoshita,Masamichi Abe,Hiroko Ikeda,Mariko Kashiwagi,Yixuan Song,Mayumi Ueta,Chie Sotozono,Zenro Ikezawa,Ryuichi Hasegawa | | Epilepsia. 2010; 51(12): 2461 | | [Pubmed] | [DOI] | | | 127 |
Genetic and ethnic risk factors associated with drug hypersensitivity |
|
| Kim, S.-H., Ye, Y.-M., Palikhe, N.S., Kim, J.-E., Park, H.-S. | | Current Opinion in Allergy and Clinical Immunology. 2010; 10(4): 280-290 | | [Pubmed] | | | 128 |
Genetic Markers and Danger Signals in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis |
|
| Wen-Hung Chung,Shuen-Iu Hung | | Allergology International. 2010; 59(4): 325 | | [Pubmed] | [DOI] | | | 129 |
Genetic and ethnic risk factors associated with drug hypersensitivity |
|
| Seung-Hyun Kim,Young-Min Ye,Nami Shrestha Palikhe,Jeong-Eun Kim,Hae-Sim Park | | Current Opinion in Allergy and Clinical Immunology. 2010; 10(4): 280 | | [Pubmed] | [DOI] | |
|
|
|
|
|
|
|
|
