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Year : 2009  |  Volume : 75  |  Issue : 5  |  Page : 549-550

Violaceous discoloration around the eyes

Department of Dermatology, Base Hospital, Delhi Cantonment, New Delhi-110 010, India

Date of Web Publication3-Sep-2009

Correspondence Address:
Biju Vasudevan
Department of Dermatology, MH Shillong, Meghalaya-793 001
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0378-6323.55425

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How to cite this article:
Vasudevan B, Sawhney M. Violaceous discoloration around the eyes. Indian J Dermatol Venereol Leprol 2009;75:549-50

How to cite this URL:
Vasudevan B, Sawhney M. Violaceous discoloration around the eyes. Indian J Dermatol Venereol Leprol [serial online] 2009 [cited 2021 Jan 24];75:549-50. Available from:

A 57-year-old male presented with dark pigmentation around the eyelids, of one-year duration. He also had joint pain and weight loss for the same duration. A general physical examination revealed pedal edema and pallor, while a systemic examination showed ascites, pleural effusion (right), and asterixis. A dermatological examination revealed violaceous pigmentation on both eyelids [Figure 1]. The patient also had similar lesions on the neck, axilla, and upper chest. Macroglossia was present as was alopecia. Investigations revealed turbidity in the urine with proteinuria of 3+ and high 24-hour urinary protein levels. Blood urea and serum creatinine were raised. An X-ray of the skull showed multiple translucencies and that of the hips and spine showed osteosclerosis. Serum electrophoresis revealed M protein with gamma spike [Figure 2]. Histopathological findings were as shown in [Figure 3].

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1.Muller AM, Geibel A, Neumann HP, Kuhnemund A, Schmitt-Graff A, Bohm J, et al . Primary (AL) amyloidosis in plasma cell disorders. Oncologist 2006;11:824-30.   Back to cited text no. 1    
2.Konig A, Wennemuth G, Soyer HP, Hoffmann R, Happle R, Krause W. Vulvar amyloidosis mimicking giant condylomata acuminata in a patient with multiple myeloma. Eur J Dermatol 1999;9:29-31.  Back to cited text no. 2  [PUBMED]  [FULLTEXT]
3.Westermark P, Benson MD, Buxbaum JN, Cohen AS, Frangione B, Ikeda S, et al . Amyloid fibril protein nomenclature- 2002. Amyloid 2002;9:197-200.  Back to cited text no. 3  [PUBMED]  
4.Comenzo RL. Primary systemic amyloidosis. Curr Treat Options Oncol 2000;1:83-9.  Back to cited text no. 4  [PUBMED]  
5.Bayer-Garner IB, Smoller BR. AL amyloidosis is not present as an incidental finding in cutaneous biopsies of patients with multiple myeloma. Clin Exp Dermatol 2002;27:240-2.  Back to cited text no. 5  [PUBMED]  [FULLTEXT]


  [Figure 1], [Figure 2], [Figure 3]


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