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Year : 2008  |  Volume : 74  |  Issue : 6  |  Page : 622--624

Keratinocyte-Melanocyte graft technique followed by PUVA therapy for stable vitiligo

Department of Dermatology, Venereology and Leprosy, Dr. S. N. Medical College, Jodhpur (Rajasthan), India

Correspondence Address:
Dilip Kachhawa
III/1, Inside main gate, Mathura Das Mathur Hospital, Jodhpur (Rajasthan)- 342 003
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0378-6323.45106

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Background: Various surgical procedures for correcting stable vitiligo exist but these have their own limitations. Autologous, non-cultured, non-trypsinized, melanocyte plus keratinocyte grafting is a new and simple method of vitiligo surgery. Objective: The study aimed to evaluate efficacy of a new grafting technique in vitiligo patches. Methods: Eighteen vitiligo patches underwent this procedure. The upper layer of epidermis was removed by superficial dermabrasion using a dermabrader micromotor until the epidermis appeared wet and shiny. Then, antibiotic ointment was applied and dermabrasion was continued up to the whitish area of the upper dermis. The paste-like material (ointment with entangled epidermal particles) was collected and spread over the dermabraded recipient site. Results: Pigmentation usually started at 4-6 weeks. Complete uniform pigmentation took 16-20 weeks. Conclusion: For smaller vitiligo patches this method gives cosmetically acceptable results. It is easy to perform and does not require specific laboratory setup.


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