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Year : 2008  |  Volume : 74  |  Issue : 3  |  Page : 299

Nodule in the nasolabial fold

1 Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
2 Department of Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Correspondence Address:
Tarun Narang
Department of Dermatology, Venereology and Leprology, PGIMER, Chandigarh - 160 012
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0378-6323.41406

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How to cite this article:
Narang T, Dogra S, Handa S, Radotra BD. Nodule in the nasolabial fold. Indian J Dermatol Venereol Leprol 2008;74:299

How to cite this URL:
Narang T, Dogra S, Handa S, Radotra BD. Nodule in the nasolabial fold. Indian J Dermatol Venereol Leprol [serial online] 2008 [cited 2020 Nov 24];74:299. Available from:

A 40-year-old female presented with spontaneous onset of a progressively enlarging nodule on the right side of her nose since 6 months. There was no history of itching, ulceration, or bleeding. She had been applying clobetasol propionate 0.05% ointment twice a day for the last 3 weeks but the lesions did not regress. Examination revealed a red-brown waxy nodule in the right nasolabial fold [Figure 1]. No regional lymph nodes were palpable. There was no lesion on any other part of her body. She did not have any systemic complaints or any significant medical illness in the past. The lesion was completely excised and sent for histopathology. The biopsy revealed abundant deposits of amorphous, faintly eosinophilic hyaline material distributed in the perivascular and periadnexal tissues in the superficial dermis [Figure 2A] and [Figure 2B]. The material stained with special stains.

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1.Breathnach SM. Amyloidosis of the skin. In : Fitzpatrick's Dermatology in General Medicine Vol. 2. In : Freedburg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI, editors. 6th ed. New York: McGraw-Hill; 2003. p. 1428-35.  Back to cited text no. 1    
2.Northcutt AD, Vanover MJ. Nodular cutaneous amyloidosis involving the vulva: Case report and literature review. Arch Dermatol 1985;121:518-21.  Back to cited text no. 2    
3.Brownstein MH, Helwig EB. The cutaneous amyloidoses, I: Localized forms. Arch Dermatol 1970;102:8-19.  Back to cited text no. 3    
4.Grunewald K, Sepp N, Weyrer K. Gene rearrangement studies in the diagnosis of primary systemic and nodular primary localized cutaneous amyloidosis. J Invest Dermatol 1991;97:693-6.  Back to cited text no. 4    
5.Wollons A, Black MM. Nodular localized primary cutaneous amyloidosis: A long-term follow-up study. Br J Dermatol 2001;145:105-9.  Back to cited text no. 5    
6.Alster TS, Manaloto RM. Nodular amyloidosis treated with the pulsed dye laser. Dermatol Surg 1999;25:133-5.  Back to cited text no. 6    
7.Truhan AP, Garden JM, Roenigk HH Jr. Nodular primary localized cutaneous amyloidosis: Immunohistochemical evaluation and treatment with the carbon dioxide laser. J Am Acad Dermatol 1986;14:1058-62.  Back to cited text no. 7    


  [Figure 1], [Figure 2A], [Figure 2B]

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