| BRIEF REPORT |
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| Year : 2006 | Volume
: 72
| Issue : 3 | Page : 211--214 |
Langerhans cell histiocytosis of skin: A clinicopathologic analysis of five cases
Rajpal Singh Punia1, Maneesh Bagai1, Harsh Mohan1, GP Thami2
1 Departments of Pathology, Govt. Medical College, Chandigarh, India
2 Departments of Dermatology, Govt. Medical College, Chandigarh, India
Correspondence Address:
Harsh Mohan
Department of Pathology, Govt. Medical College, Sector 32 A, Chandigarh
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0378-6323.25782
Background and Aims: Langerhans cell histiocytosis (LCH) is a rare proliferative disorder of histiocytes characterized by a proliferation of abnormal and clonal Langerhans cells. We retrospectively studied clinicopathologic features of this disorder in five cases. Methods: Clinical and histopathological findings of five cases of cutaneous LCH were reviewed based on the hospital records. Results: The age of patients ranged from 28 days to 5 years and M: F ratio was 1:1.5. Clinically, the diagnoses suggested were histiocytosis, varicella, transient neonatal pustular melanosis, keloid, sarcoidosis, seborrheic keratosis and LCH. The most common type of skin lesion was a generalized papular lesion. Histologically, all cases showed aggregates of large mononuclear histiocytes (Langerhans cells) with reniform, irregular, cleaved nuclei and abundant eosinophilic cytoplasm. There was multi-systemic involvement in two patients and single-system involvement in three patients. Conclusion: Cutaneous lesions may be the sole presenting feature of LCH. Diagnosis is based on demonstration of S-100 positive histiocytes.
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