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 ORIGINAL ARTICLE
Year : 2006  |  Volume : 72  |  Issue : 3  |  Page : 203--206

Study of desmoglein 1 and 3 antibody levels in relation to disease severity in Indian patients with pemphigus


1 Departments of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
2 Departments of Immunopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Correspondence Address:
Bhushan Kumar
Department of Dermatology, Venereology and Leprology,PGIMER, H. No. 81, Sector 16, Chandigarh 160 015
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0378-6323.25780

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Objectives : To conduct a cross-sectional study to compare Dsg1 and Dsg3 antibody levels independently with severity of disease activity in pemphigus vulgaris (PV) and pemphigus foliaceus (PF). Methods : Blood samples from 44 patients with pemphigus (PV-38, PF-6) were analyzed using ELISA. The severity of skin and mucosal disease was graded using a score from 0 to 3. Results: A statistically significant correlation between increase in Dsg 3 antibody titres with severity of oral involvement and Dsg 1 titres with severity of skin involvement was found in both PV and PF patients ( p <0.01). However, we were unable to demonstrate a relationship between increased titres of Dsg1 and Dsg 3 antibodies with oral and skin involvement respectively. Conclusion : This study suggests that the severity of skin and oral disease in pemphigus is determined by the quantities of Dsg1 and Dsg3 antibodies respectively.






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