Indexed with PubMed and Science Citation Index (E) 
Users online: 1339 
     Home | Feedback | Login 
About Current Issue Archive Ahead of print Search Instructions Online Submission Subscribe What's New Contact  
    Next article
    Previous article
    Table of Contents

    Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
  Related articles
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded0    
    Comments [Add]    

Recommend this journal


Year : 2003  |  Volume : 69  |  Issue : 1  |  Page : 19--22

Multicenter study to evaluate efficacy and irritation potential of benzoyl peroxide 4% cream in hydrophase base (Brevoxyl) in acne vulgaris

Department of Skin & STD, Grant Medical College, Mumbai, India

Correspondence Address:
C M Oberai
Department of Skin & STD, Grant Medical College, Mumbai
Login to access the Email id

Source of Support: None, Conflict of Interest: None

PMID: 17642816

Rights and PermissionsRights and Permissions

In this multicenter, open, non-comparative study, the efficacy and irritation potential of 4% benzoyl peroxide cream in hydrophase base (Brevoxyl) was evaluated for the treatment of acne vulgaris. All evaluable patients (n=567) received treatment with 4% benzoyl peroxide cream in hydrophase base for six weeks. The investigators evaluated the patients at baseline and at 1,2,4 & 6 weeks. Patients also rated their improvement and adverse effects. Doctor's assessment showed that at the end of 6'h week 85.6% had good to very good effect of the treatment. The profile of side effects observed by doctors revealed that 53.8% of total patients did not have any irritation whereas only 11.6% had moderate to severe irritation. 53.8% of patients did not report any irritation: 41.4% had some irritation whereas only 4.8% patients reported troublesome irritation. A satisfactory response was reported as ear;y as two weeks and most of the patients had a very satisfactory response after six weeks and were willing to continue the treatment. This supports the theory that the hydrophase formulation in 'Brevoxyl helped to enhance efficacy and decrease the irritation associated with use of benzoyl peroxide.

[FULL TEXT] [PDF Not available]*

Print this article     Email this article

Online since 15th March '04
Published by Wolters Kluwer - Medknow