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Year : 2002  |  Volume : 68  |  Issue : 6  |  Page : 365-366

Benign rheumatoid nodules

Command Hospital (Air Force) Bangalore-560 007, $-7 Air Force Hospital, Kanpur, India

Correspondence Address:
(Dermatology & STD), Command Hospital (AF), Bangalore-560 007, India


Rheumatoid nodules occur usually in advanced seropositive rheumatoid arthritis, signifying poor prognosis. However rarely rheumatoid nodules can be encountered in patients with no antecedent evidence of arthritis. Herein a case of an arthritic benign rheumatoid nodules is described.

How to cite this article:
Murthy P S, Malik A K, Rajagopal R, Aggarwal S K. Benign rheumatoid nodules . Indian J Dermatol Venereol Leprol 2002;68:365-6

How to cite this URL:
Murthy P S, Malik A K, Rajagopal R, Aggarwal S K. Benign rheumatoid nodules . Indian J Dermatol Venereol Leprol [serial online] 2002 [cited 2020 Oct 24];68:365-6. Available from:

   Introduction Top

Rheumatoid nodules are palpable subcutaneous nodules that occur in about 20% of patients with rheumatoid arthritis.[1] These nodules are almost invariably associated with more severe forms of the disease, wherein rheumatoid factor and antinuclear factor are frequently found in the serum. Here we report a case of anarthritic rheumatoid nodules.

   Case Report Top

A 51-year-old healthy male reported with complaints of slow growing painless nodule over right elbow of two years duration. Six months after onset of the elbow lesion, he noticed similar painless nodules over the knuckles of right hand, palmar surface of right hand and over the left thumb. There was no history of itching, pain, discharge or ulceration of the nodules. He denied any past or present history of joint pains, swelling of joints, morning stiffness, subcutaneous nodules elsewhere on the body, deformities or any associated fever.
Dermatological examination revealed multiple, firm to hard, discrete, non tender nodular lesions on dorsal surface of knuckles of right hand, palmar surface of right hand, dorsa of interphalangeal joint of left hand and palmar surface of left thumb [Figure - 1]. There was a large nodule on the posterior aspect of the right elbow [Figure:2]. Skin over the surface was normal. Nodules were not fixed to the tendons or bone. There were no yellowish deposits or any cutaneous signs of hyperlipidemia anywhere on the body. Investigations in the form of lipid profile, X-ray of hands and elbows and ESR were normal. Rheumatoid factor was strongly positive. Excision biopsy of elbow nodule revealed numerous necrobiotic histiocytic granulomas with cuffing of lymphocytes. Numerous Langhans giant cells were also seen. Histopathology thus was consistent with the clinical diagnosis of rheumatoid nodules.
The nodules were surgically removed for cosmetic benefit. There has been no recurrence for one year postoperatively though the patient needs further follow-up.

   Discussion Top

Rheumatoid nodules occur generally in 20-25% of patients with severe rheumatoid arthritis and imply aggressive disease with poor prognosis.[1] However benign rheumatoid nodules have been reported in patients with little arthritis and no systemic disease. Rheumatoid factor may be positive in high titre, nodules usually involve elbows, hand and feet with a predilection for tendons and multiple cyst like intraosseous radioluscencies may be associated.[2] They occur particularly at sites of repeated minor trauma. Benign rheumatoid nodules are more common in children than in adults and are considered exceptional beyond the age of eighteen.[3] In the literature only two hundred cases in children and 25 cases in adults have been documented with histological confirmation.[3] Adult onset benign rheumatoid nodules are clinically and histologically identical to those found in rheumatoid arthritis. They often appear in women during their twenties, frequently resolved spontaneously or were adequately treated by excision and recurred in about one-third of patients. None of the patients in literature subsequently developed rheumatoid arthritis during follow-up periods for as long as 20 years.[4] Deep granuloma annulare may be considered in the differential diagnosis when it appears in adults.[5]
Surgical treatment is effective in treating benign rheumatoid nodules for cosmetic benefit or may be necessary if there is local pain, nerve impression, erosions, infection or limited range of motion.[6] 

   References Top

1.Rowell NR, Goodfield MJD. Dermatological manifestations of rheumatoid disease. In: Champion RH, Burton JL, Ebling FJG, Editors. Textbook of Dermatology 4th edition, Oxford; Blackwell Scientific Publications: 1992;2286-2289.   Back to cited text no. 1    
2.Wisnieski JJ, Askori AD. Rheumatoid nodulosis. A relatively benign rheumatoid variant. Arch Intern Med 1981, 141: 615-619.   Back to cited text no. 2    
3.Medrano Son Ildenfonso M, Ferrer Lozarro M, Pastor Mouron I, et al. Benign rheumatoid nodules. Report of 4 cases. An Med Interno 1998;15: 379-380.   Back to cited text no. 3    
4.Cohen PR, Kurzrock R. Benign rheumatoid nodules in a woman with chronic lymphocytic leukemia and borderline lepromatous leprosy. Am Rheum Disl 993;52:685-688.   Back to cited text no. 4    
5.Salomon RJ, Gardepe SF, Woodly DT Deep granuloma annulare in adults. IntJ Dermatol 1986;25:109-112.   Back to cited text no. 5    
6.Arnold C. The management of rheumatoid nodules. Am J Ortho 1996;25: 706-708.   Back to cited text no. 6    


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