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Year : 2002  |  Volume : 68  |  Issue : 2  |  Page : 78--81

A comparative clinical study of sisomicin cream versus mupirocin ointment in pyodermas

1 Dept. of Skin, STD & Leprosy, Grant Medical College & Sir J. J. Group of Hospitals J. J. Road, Byculla, Mumbai, India
2 BJ Medical College Pune, India
3 Government Medical College, New Civil Hospital, Surat, India

Correspondence Address:
Chetan Oberai
Dept. of Skin, STD & Leprosy, Grant Medical College & Sir J. J. Group of Hospitals J. J. Road, Byculla, Mumbai
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Source of Support: None, Conflict of Interest: None

PMID: 17656883

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This study was designed to compare the efficacy and safety of sisomicin cream (0.1%) or mupirocin ointment (2%) in the treatment of primary or secondary pyodermas requiring topical antibiotic therapy alone. In the evaluable patients (n=290), impetigo was the commonest clinical condition reported. Staphylococcus aureus was the commonest pathogen isolated from the lesons. Both sisomicin and mupirocin treatments produced a steady improvement in the scores of erythema, oedema, vesiculation, pustulation, crusting and scaling but the improvement produced by sisomicin was quicker and more pronounced. The percentage of patients with complete clearing of all lesions was also higher with sisomicin than with mupirocin on days 4, 8 and 14. Patients subjectively rated the sisomicin formulation as excellent in 75% of cases as against 59% with mupirocin. Sisomicin and mupirocin are effective and safe in the management of pyodermas; however sisomicin therapy resulted in faster and greater relief of signs and symptoms.

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Online since 15th March '04
Published by Wolters Kluwer - Medknow