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Year : 2001  |  Volume : 67  |  Issue : 5  |  Page : 264-265

Intraoral giant condyloma acuminatum

Department of Dermatology, Government Medical College and Hospital, Faridkot-151 203 (Punjab), India

Correspondence Address:
Department of Dermatology, Government Medical College and Hospital, Faridkot-151 203 (Punjab), India


A case of intraoral giant condyloma acuminatum is reported in a 50- year- old Indian. He did not respond to topical application of podophyllin 20% but responded partially to electric cauterisation. Surgical excision was done to get rid of the warty growh completely. Since there were no skin or genital lesions and no history of marital or extramarital sexual contact the lesion was probably acquired from environmental sources. Nonsexual transmission should be considered especially when the lesions are extragenital.

How to cite this article:
Gupta R R, Puri U P, Mahajan B B, Sahni S S, Garg G. Intraoral giant condyloma acuminatum. Indian J Dermatol Venereol Leprol 2001;67:264-5

How to cite this URL:
Gupta R R, Puri U P, Mahajan B B, Sahni S S, Garg G. Intraoral giant condyloma acuminatum. Indian J Dermatol Venereol Leprol [serial online] 2001 [cited 2020 Oct 28];67:264-5. Available from:

   Introduction Top

The condyloma acuminatum is a benign epithelial proliferation that occurs most frequently on the mucous membranes of perianal and genital areas of men and women.[1] The causative agent of this lesion is papova group viruses.[2] Condylomata acuminata are now thought to be one of the four most common sexually transmitted diseases and second only to genital herpes among the sexually transmissable viruses.[3] Intraoral condyloma acuminatum is rare[4] and has been reported most commonly in the temperate and developed parts of the world. This case is reported because of extreme rarity of the condition and also to focus attention on the nonsexual means of transmission.

   Case Report Top

A 50-year-old man presented in the Dermatology department of Govt. Medical College, Faridkot in March, 1999 with a warty growth of size 5 x 7 cms. covering right half of inner mucosal surface of lower lip which had seedings on the apposing surface of lower gum for the last one year [Figure - 1]. Lesion started as a white pea sized papule in the vestibule portion of oral cavity. It persisted and enlarged slowly for one year to acquire the present size. Both patient and his wife denied history of marital or extra - marital sexual contact for the last 1 years. About one and a half years back, patient had undergone surgical bone plating under spinal anaesthesia after fracture of both bones of the right lower leg.
On examination, warty growth had pinkish white colour and granular surface with fissures extending into underlying mucous membrane. Surrounding mucous membrane also gave a whitish hue. Genitalia, rectal mucosa and perianal skin were normal with no warty growth. Examination of patient's wife failed to detect any genital or skin warts.
All the routine investigations were done. All values were within normal limits. VDRL test and ELISA test for HIV 1 and 2 on blood of patient and his wife gave negative results. Biopsy specimen from growth showed parakeratosis, papillomatosis and acanthosis. There was marked koilocytosis of the superficial layer of epithelium. The epithelial papillae were supported by a fibrovascular core with dilated capillaries. Basal layer showed occasional mitosis. These histological features were consistent with those of condyloma acuminatum.
Topically 20% podophyllin in tincture benzoin was applied to the warty growth for three consecutive applications at weekly intervals. Warty growth did not show any sign of regression. Electrocautery of the lesion was done four times at fortnightly interval. Warty growth showed regression up to 75%. As the warty growth had not disappeared completely and was recurrent after electrocauterisation, it was decided to go for surgical excision.

   Discussion Top

Condyloma acuminatum has been reported to affect the mucous membranes of the gingiva, cheeks, lips and hard palate. This is quite understandable as the oral cavity has a mucocutaneous junction similar to vagina and anus. Some patients with condyloma acuminatum had concurrent genital or anal warts. Some gave a history of oral sex with partners with condylomata acuminata. There were no warts on the genitalia or skin of the patient or his wife. Neither there was any marital or extramarital sexual contact for the last one and a half year nor the patient was in a position to have sexual contact as he was confined to bed for last 1 years. In this case acquisition of lesions remains an enigma. As there was no history of sexual contact and no other lesions were found on the body, other possible modes of transmission of this virus have to be considered. Transmission of HPV by anogenital contact is clearly possible but non-sexual transmission may also occur.[6] Evidence has suggested that skin and genital warts may be caused by different agents and that skin warts appear to be acquired from environmental sources such as public bathing facilities.[7] Genital warts are acquired sexually with peak occurrence in third decade of life. Further studies are needed of the mode of transmission of papova viruses especially in relation to warts. Meanwhile, nonsexual modes of transmission of this virus may be a real possibility especially when condyloma acuminatum occurs at extragenital sites. 

   References Top

1.Elder David, Elenitsas Rosalie, Jaworsky Christine, et al. Lever's Histopathology of the Skin. 1997 ; 8th ed ; 583.  Back to cited text no. 1    
2.Oriel JD, Almeila JD. Demonstration of virus particles in human genital warts. Br J Vener Dis 1970 ; 46 : 37 - 42.  Back to cited text no. 2    
3.Wright RA, Judson FN. Relative and seasonal incidence of sexually transmitted diseases. A two year statistical review. Br J Vener Dis 1978 ; 54 : 433-440.  Back to cited text no. 3    
4.Summers L, Booth DR. Intraoral condyloma acuminatum. Oral surg 1974; 38 : 273 - 278.  Back to cited text no. 4    
5.Marklov VP. Affection of the vermillion border of mucous membrane of the lips in a patient with condyloma acuminatum. Vestn Dermatol Venereol 1971 ; 45 : 69.  Back to cited text no. 5    
6.Ashiru J0, Ogunbawjo BO, Rotowal NA, et al. Intraoral condylomata acuminata. Br J Vener Dis 1983 ; 59 : 325 - 326.  Back to cited text no. 6    
7.Oriel JD. Natural history of genital warts. Br J Vener Dis 1971 ; 47: 1-13.1  Back to cited text no. 7    


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