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Year : 1999  |  Volume : 65  |  Issue : 4  |  Page : 172--173

A clinico - histopathological outcome of 4 weeks methotrexate pulse therapy in psoriasis

Department of Dermatology, Venereology & Leprosy, RNT Medical College, Udaipur, India

Correspondence Address:
M K Singhi
Q.No. 3/2 MDM Hospital Campus, Shastri Nagar, Jodhpur (Rajasthan)
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Source of Support: None, Conflict of Interest: None

PMID: 20921647

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A clinico - histopathological study was carried out In 50 patients of psoriasis to see clinical and histological outcome and/or correlation of weekly methotrexate pulse therapy. Clinically, results of therapy were evalutated by estimating the percentage of total body coverage with psoriasis. Prior to therapy, average involvement was 47.5% which after 4 weeks methotrexate therapy reduced to 8.3%. A complete clearing of psoriasis occurred in 40% of patients after methotrexate therapy. The clinical response started as early as 1 week in most of patients. Only 2 patients failed to respond even after 4 weeks of therapy. Histopathologically in pretreatment biopsy, 34 showed classical psoriatic pathology while in 16 biopsy was suggestive of psoriasis but not confirmative. Histopathological examination after 4 weeks treatment showed that 41 still showed one or more histological evidence of psoriasis, although only two patients had classical, psoriatic pathology, in rest 9 patients there were complete regression. Thus, with methotrexate, clinical clearance was much faster than histopathological clearance.


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Online since 15th March '04
Published by Wolters Kluwer - Medknow