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Year : 1999  |  Volume : 65  |  Issue : 3  |  Page : 122--123

Short-term treatment of pityrosporum folliculitis with itraconazole

Department of Dermatology and Department of PSM (Biostatistics), Himalayan Institute of Medical Sciences, Jolly Grant, Dehradun, India

Correspondence Address:
D Parsad
Dept. of Dermatology, Himalayan Institute of Medical Sciences, Jolly Grant. Dehradun, U.P. - 248 140
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Source of Support: None, Conflict of Interest: None

PMID: 20921630

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We compared the efficacy and safety of short-term itraconazole with that of placebo in 26 patients of pityrosporum folliculitis. Twenty-six patients of mycologically proven pityrosporum folliculitis entered a double-blind placebo-controlled trial. Patients were randomly assigned to 7 days of treatment with either itraconazole, 200 mg once daily, or placebo. A global clinical assessment and micological examination (KOH und smear examination) were performed at baseline and at 4 weeks after treatment. In this study, itraconazole in a dose of 200mg for 7 days produced a distinct and statistically significant improvement over placebo (p<0.01). 84.6% of itraconazole treated patients were considered to be healed or markedly improved at the study’s end point compared with 8.3% of placebo treated group (p<0.0). Eighty-four percent of patients receiving active treatment showed negative mycological examination as compared to 8.3% of placebo-treated group (p<0.0l). Short-term treatment with itraconazole is effective and well tolerated in the management of pityrosporum folliculitis.


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Online since 15th March '04
Published by Wolters Kluwer - Medknow