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Year : 1994  |  Volume : 60  |  Issue : 1  |  Page : 54-55

Generalized acute mucocutaneous herpes simplex

Correspondence Address:
R R Mittal

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A case of generalized acute mucocutaneous herpes simplex is reported in a 15 years old boy. There was neither underlying disease nor any evidence of genetic or acquired immune deficiency.

Keywords: Herpes simplex, Mucoccutaneous, Generalised acute

How to cite this article:
Mittal R R, Walia R, Jain C. Generalized acute mucocutaneous herpes simplex. Indian J Dermatol Venereol Leprol 1994;60:54-5

How to cite this URL:
Mittal R R, Walia R, Jain C. Generalized acute mucocutaneous herpes simplex. Indian J Dermatol Venereol Leprol [serial online] 1994 [cited 2020 Oct 22];60:54-5. Available from:

  Introduction Top

Herpes simplex usually remains localized to certain body regions usually around mouth, genitalia, eyes and small areas of skin. A rare presentation of herpes simplex is rapid progression to varicelliform eruption simulating lesions of chickenpox in patients who have no preexisting skin disease; [1] rarely death can occur without visceral lesion. [2]

We report a patient of Herpes simplex orofacialis which rapidly disseminated into varicella like eruption.

  Case Report Top

A 14-years-old male was admitted in dermatology ward with vesicles around mucocutaneous junctions. Grouped vesicles on an erythematous base were present on both lips, around mouth, nose and eyes. There were painful red erosions on buccal mucosa, palate, tongue and pharynx. No systemic abnormality was detected.

History of repeated bacterial or fungal infections in patient or in family was absent. There was no evidence of any immune deficiency in the patient.

Routine investigations were within normal range. Tzanck smear from the floor of the bulla showed many multinucleated acantholytic baloon cells.

After 2 days, patient developed fever and discrete vesicular eruptions appeared on back, trunk and thighs. The lesions were on inflamed base and umblicated in the centre, Tzanck smear from the base of vesicle again showed multinucleated acantholytic baloon cells.

Patient was put on topical and oral Acyclovir 200 mg 5 times a day. On 3 day the disseminated vesicles started regressing. Fever disappeared. Oral therapy was stopped after 5 days. Complete recovery occured after 2 weeks of topical and supportive therapy.

  Comments Top

Longg et al reported 8 cases of varicella like eruption due to herpes simplex out of which 7 were having underlying diseases like, Hodgkins disease, Leukemia, SLE etc and only 1 case was without. any underlying disease. [3] Similarly our patient also did not show any underlying disease, immune deficieny or malignancy.

To the bset of our knowledge this is the first case report of generalized acute mucocutaneouse herpes simplex from India.

  References Top

1.Long JC, Wheeler CE Jr, Briggaman RA. Varicella like infection due to herpes simplex. Arch Dermatol 1978; 114: 406-9.  Back to cited text no. 1  [PUBMED]  
2.Lopyan L, Young AW Jr, Menegus M. Generalized acute mucocutaneous herpes simplex type 2 - with fatal outcome. Arch Dermatol 1977; 113 : 816-8.  Back to cited text no. 2  [PUBMED]  
3.Kipping RH, Downie AW. Generalized infection with the virus of herpes simplex. Br Med J 1948; 10 : 247-9.  Back to cited text no. 3    


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