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Year : 1992  |  Volume : 58  |  Issue : 6  |  Page : 368--371

In vitro susceptibility of dermatophytes to itraconazole

Correspondence Address:
V Pankajalakshmi Venugopal

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Source of Support: None, Conflict of Interest: None

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The in vitro activity of itraconazole was investigated against 88 clinical isolates of dermatophytes. The isolates included Microsporum canis-50, M. audovinii-5, Trichophyton rubrum-6, T. mentagraphytes-5 T.violaceum-12, T.simii-5, T verrucosum-1, T.soundanense-1, T. erinacei-1 and Epidermophyton flooccosum-2 isolates. The results were compared with that of ketoconazole and griseofulvin. Itraconazole was more active, inhibiting 85 of the 88 isolates at a concentration of 0.5 g/ml (MIC range 0.01-1 g/ml). Ketoconazole (MIC range 0.1-10 g/ml) required 2.5 g/ml and 5 g/ml of the drug respectively for inhibition of all the isolates except one of Microsporum species.

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Online since 15th March '04
Published by Wolters Kluwer - Medknow