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Year : 1991  |  Volume : 57  |  Issue : 5  |  Page : 244-245

Favre-racouchot syndrome

Correspondence Address:
Vinay Kulkarni

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A case of Favre-Racouchot Syndrome with nodular elastoidosis, cysts and comedones is reported.

Keywords: Nodular Elastoidosis with Cysts and Comedones, Favre-Racouchot Syndrome.

How to cite this article:
Kulkarni V. Favre-racouchot syndrome. Indian J Dermatol Venereol Leprol 1991;57:244-5

How to cite this URL:
Kulkarni V. Favre-racouchot syndrome. Indian J Dermatol Venereol Leprol [serial online] 1991 [cited 2020 Dec 3];57:244-5. Available from:

Nodular elastoidosis with cysts and comedones or Favre-Racouchot Syndrome (FRS) is a peculiar complication of solar (se­nile) degeneration of the skin characterized by the presence of multiple comedones, follicular cysts, furrows, and yellowish nodules found most commonly in the periorbital region of elderly individuals.[1] Since the original descrip­tion, many cases have been reported in the world literature, and the disease has been estimated to occur in approximately 6% indi­viduals over the age of 50[2] It is found pre­dominantly in white men who have had ex­tensive exposure to sun and weather.[3]

Although reported to be so common in white men it has not been reported in Indian literature.

  Case Report Top

A 80-year-old male was admitted in the hospital for chronic renal failure. The renal failure was refractory to routine line of man­agement. The patient had peculiar dermato­logical features on the face. The skin was atrophic, and showed wrinkles, furrows, comedones, small cysts, and numerous small papules and nodules [Figure - 1]. The comedones had a patulous opening with dark central plug. Similar lesions were present on the neck but exposed parts of the extremities were spared. The patient was a businessman and had traveled a lot in sun. The lesions were present for at least 20 years.

The laboratory investigations were sug­gestive of chronic renal failure, but were non-contributory as far as the skin condition was concerned. The patient refused to un­dergo a biopsy. Diagnosis of FRS was made based only on the clinical features.

  Comments Top

FRS is a peculiar dermatosis. Based on clinical, histologic and histochemical studies it is believed to be variant of cutaneous senile atrophy, resulting from the prolonged action of ultraviolet light and other physical climatic agents in the predisposed skin.[1] The pig­mented skin seems to be less predisposed than the white skin. Histopathology is seldom required for diagnosis but is characteristic.[4] There is atrophy of the epidermis with mas­sive basophilic (actinic) degeneration of the connective tissue in the upper dermis. Elastic tissue stains show nodular aggregates of elastotic material in areas where degeneration is most pronounced. The infundibula of the pilosebaceous units are dilated to form keratin-filled comedones and follicular cysts. Patient refused any treatment. There is little benefit from the use of acne peeling lotions and comedone extraction.[1] Dermabrasion, curettage, plastic surgery have been tried.[1] Several reports have indicated good results with topical application of tretinoin.[5],[6]

  References Top

1.Pelachyk JM : Nodular elastoidosis with cysts and comedones, in : Clinical Dermatology, Editor, Demis DJ : Harper and Row, Philadelphia, 1987; Vol 1, Unit 4-44 : p 1-3.  Back to cited text no. 1    
2.Friedman SJ and Su DWP : Favre-Racouchot syn­drome associated with radiation therapy, Cutis, 1983; 31 : 306-310.  Back to cited text no. 2    
3.Helm F : Nodular cutaneous elastoidosis with cysts and comedones (Favre-Racouchot syndrome), Arch Dermatol, 1961; 84 : 182-184.  Back to cited text no. 3    
4.Lever WF and Schaumburg-Lever G : Degenera­tive Diseases, in : Histopathology of the Skin, 7th ed, JB Lippincott, Philadelphia, 1990; p 300.  Back to cited text no. 4    
5.Plewig G : Dermabrasion for nodular cutaneous elastosis with cysts and comedones, Arch Dermatol, 1972; 105 : 294-296.  Back to cited text no. 5    
6.Kligman AM, Plewig G and Mills OH Jr: Topically applied tretinoin for senile (solar) comedones, Arch Dermatol, 1971; 104 : 420-421.  Back to cited text no. 6    


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