|Year : 1991 | Volume
| Issue : 5 | Page : 244-245
Source of Support: None, Conflict of Interest: None
A case of Favre-Racouchot Syndrome with nodular elastoidosis, cysts and comedones is reported.
Keywords: Nodular Elastoidosis with Cysts and Comedones, Favre-Racouchot Syndrome.
|How to cite this article:|
Kulkarni V. Favre-racouchot syndrome. Indian J Dermatol Venereol Leprol 1991;57:244-5
Nodular elastoidosis with cysts and comedones or Favre-Racouchot Syndrome (FRS) is a peculiar complication of solar (senile) degeneration of the skin characterized by the presence of multiple comedones, follicular cysts, furrows, and yellowish nodules found most commonly in the periorbital region of elderly individuals. Since the original description, many cases have been reported in the world literature, and the disease has been estimated to occur in approximately 6% individuals over the age of 50 It is found predominantly in white men who have had extensive exposure to sun and weather.
Although reported to be so common in white men it has not been reported in Indian literature.
| Case Report|| |
A 80-year-old male was admitted in the hospital for chronic renal failure. The renal failure was refractory to routine line of management. The patient had peculiar dermatological features on the face. The skin was atrophic, and showed wrinkles, furrows, comedones, small cysts, and numerous small papules and nodules [Figure - 1]. The comedones had a patulous opening with dark central plug. Similar lesions were present on the neck but exposed parts of the extremities were spared. The patient was a businessman and had traveled a lot in sun. The lesions were present for at least 20 years.
The laboratory investigations were suggestive of chronic renal failure, but were non-contributory as far as the skin condition was concerned. The patient refused to undergo a biopsy. Diagnosis of FRS was made based only on the clinical features.
| Comments|| |
FRS is a peculiar dermatosis. Based on clinical, histologic and histochemical studies it is believed to be variant of cutaneous senile atrophy, resulting from the prolonged action of ultraviolet light and other physical climatic agents in the predisposed skin. The pigmented skin seems to be less predisposed than the white skin. Histopathology is seldom required for diagnosis but is characteristic. There is atrophy of the epidermis with massive basophilic (actinic) degeneration of the connective tissue in the upper dermis. Elastic tissue stains show nodular aggregates of elastotic material in areas where degeneration is most pronounced. The infundibula of the pilosebaceous units are dilated to form keratin-filled comedones and follicular cysts. Patient refused any treatment. There is little benefit from the use of acne peeling lotions and comedone extraction. Dermabrasion, curettage, plastic surgery have been tried. Several reports have indicated good results with topical application of tretinoin.,
| References|| |
|1.||Pelachyk JM : Nodular elastoidosis with cysts and comedones, in : Clinical Dermatology, Editor, Demis DJ : Harper and Row, Philadelphia, 1987; Vol 1, Unit 4-44 : p 1-3. |
|2.||Friedman SJ and Su DWP : Favre-Racouchot syndrome associated with radiation therapy, Cutis, 1983; 31 : 306-310. |
|3.||Helm F : Nodular cutaneous elastoidosis with cysts and comedones (Favre-Racouchot syndrome), Arch Dermatol, 1961; 84 : 182-184. |
|4.||Lever WF and Schaumburg-Lever G : Degenerative Diseases, in : Histopathology of the Skin, 7th ed, JB Lippincott, Philadelphia, 1990; p 300. |
|5.||Plewig G : Dermabrasion for nodular cutaneous elastosis with cysts and comedones, Arch Dermatol, 1972; 105 : 294-296. |
|6.||Kligman AM, Plewig G and Mills OH Jr: Topically applied tretinoin for senile (solar) comedones, Arch Dermatol, 1971; 104 : 420-421. |
[Figure - 1]