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Year : 1990  |  Volume : 56  |  Issue : 3  |  Page : 234--235

Pemphigus foliaceous induced by penicillamine

Correspondence Address:
K Kaushal Verma

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Source of Support: None, Conflict of Interest: None

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A 44 year old man having rhcumatoid arthritis developed pemphigus foliaccous after 7 months of taking 500: mg D-penicillamine a day. The lesions regressed on stopping the drug and reappeared whet the drug was started again. Skin biopsy revealed a subcorneal split suggestive of pemphigus foliaceous. Direct immunofluorescent staining of the skin biopsy for IgG revealed an intercellular pattern and the indirect immunofluorescent on the patient's serum revealed a titre of 1 : 10. The lesions disappeared within 2 weeks of discontinuation of the drug.

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Online since 15th March '04
Published by Wolters Kluwer - Medknow