| ORIGINAL CONTRIBUTION
|Year : 1985 | Volume
| Issue : 4 | Page : 198--201
Effect of Prothionamide on the Infectivity of Lepromatous Leprosy
A Girdhar, BK Girdhar, Sreevatsa, G Ramu, RK Lavania, KV Desikan
To study the effect of prothionamide. on the infectivity of untreated lepromatous patients 20 cases were randomly given either 250 mg or 500 mg prothionamide monotherapy daily for 2 months. All patients tolerated the drug well. Clinical improvement with healing of mucosal ulcers was seen in 13 of the 16 cases. Nasal smears become negative in all the cases within 2 months. Mouse footpad inoculation done from biopsy specimens/skin scrape suspension- s became non infective to mice in all the cases within the trial period. There was a substantial reduction in ,the MI and histopathology showed complete fragmentation of the bacilli with a significant increase in the lymphocyte content. The -findings suggest a rapid bactericidal effect and a similar, use fullness on both the doses of the drug for the treatment of multibacillary leprosy.
Source of Support: None, Conflict of Interest: None