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Figure 2: Schematic model of autophagy. The class III phosphatidylinositol 3-kinase complex activation occurs downstream to the unc-51-like kinase complex. The class III phosphatidylinositol 3-kinase complex recruits autophagy-related proteins at the phagophore assembly site and initiates phagophore formation. Phagophore elongates to forms a vesicular structure, autophagosome. Mature autophagosome fuses with lysosome, thereby forming single membrane structure, autolysosome

Figure 2: Schematic model of autophagy. The class III phosphatidylinositol 3-kinase complex activation occurs downstream to the unc-51-like kinase complex. The class III phosphatidylinositol 3-kinase complex recruits autophagy-related proteins at the phagophore assembly site and initiates phagophore formation. Phagophore elongates to forms a vesicular structure, autophagosome. Mature autophagosome fuses with lysosome, thereby forming single membrane structure, autolysosome