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Figure 3: (a) The histopathology of the small nodule showed nests of melanocytes in the epidermal basal layer and round-to-cuboidal cells with maturation in the dermis. The histopathology of the macule showed proliferation of spindle-shaped atypical melanocytes in the epidermal basal layer and superficial and middle dermis (left side, melanoma; right side, nevus; hematoxylin– eosin (H and E) staining, original magnification ×40). (b) Higher magnification of the round-to-cuboidal cells (H and E staining, original magnification ×400). (c) Higher magnification of the atypical melanocytes (H and E staining, original magnification ×400). (d) The melanocytes, atypical melanocytes and round-to-cuboidal cells were positive for S100 (left side, melanoma; right side, nevus; original magnification ×40). (e) The melanocytes and atypical melanocytes were positive for HMB-45, but the round-to-cuboidal cells were negative for HMB-45 (left side, melanoma; right side, nevus; original magnification ×40). (f) Higher magnification of the atypical melanocytes (HMB-45 staining, original magnification ×400). (g) Higher magnification of the round-to-cuboidal cells (HMB-45 staining, original magnification ×400)

Figure 3: (a) The histopathology of the small nodule showed nests of melanocytes in the epidermal basal layer and round-to-cuboidal cells with maturation in the dermis. The histopathology of the macule showed proliferation of spindle-shaped atypical melanocytes in the epidermal basal layer and superficial and middle dermis (left side, melanoma; right side, nevus; hematoxylin– eosin (H and E) staining, original magnification ×40). (b) Higher magnification of the round-to-cuboidal cells (H and E staining, original magnification ×400). (c) Higher magnification of the atypical melanocytes (H and E staining, original magnification ×400). (d) The melanocytes, atypical melanocytes and round-to-cuboidal cells were positive for S100 (left side, melanoma; right side, nevus; original magnification ×40). (e) The melanocytes and atypical melanocytes were positive for HMB-45, but the round-to-cuboidal cells were negative for HMB-45 (left side, melanoma; right side, nevus; original magnification ×40). (f) Higher magnification of the atypical melanocytes (HMB-45 staining, original magnification ×400). (g) Higher magnification of the round-to-cuboidal cells (HMB-45 staining, original magnification ×400)