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Figure 1: (a) A brown plaque on the right lower eyelid. (b) Dermoscopy. A brain-like brown structure (arrow) and small pale-pink patches arranged in a fl ower-like fashion (circle). An arrowhead indicates a biopsy scar. (c, d) Full thickness of the epidermis replaced by atypical keratinocytes, mild chronic inflammatory cells and amyloid deposition in the dermis. The epidermis on the left side shows relatively regular acanthosis by atypical keratinocytes and scarce amyloid deposition. The right side also shows Bowen's disease, with irregularly elongated rate ridges, abundant amyloid deposition and underlying infl ammatory cell infi ltrates. c: H and E staining ×20; d: Dylon staining ×20, (e) High-power view of the specimen reveals atypical keratinocytes, occasional clumping cells and dyskeratotic cells

Figure 1: (a) A brown plaque on the right lower eyelid. (b) Dermoscopy. A brain-like brown structure (arrow) and small pale-pink patches arranged in a fl ower-like fashion (circle). An arrowhead indicates a biopsy scar. (c, d) Full thickness of the epidermis replaced by atypical keratinocytes, mild chronic inflammatory cells and amyloid deposition in the dermis. The epidermis on the left side shows relatively regular acanthosis by atypical keratinocytes and scarce amyloid deposition. The right side also shows Bowen's disease, with irregularly elongated rate ridges, abundant amyloid deposition and underlying infl ammatory cell infi ltrates. c: H and E staining ×20; d: Dylon staining ×20, (e) High-power view of the specimen reveals atypical keratinocytes, occasional clumping cells and dyskeratotic cells