IJDVL Close
 

Figure 2: Ovarian steroidogenesis: Granulosa cells form the inner lining of the ovarian follicle. The thecal cells abut them and form the outer layer. Granulosa cells are dependent on the diffusing androstenedione from the theca cells for substrate as they are not in direct connection with the circulation (Two cell hypothesis). All steroid hormones are derived from cholesterol. Its entry into the mitochondria is mediated by StAR (Steroidogenic acute regulatory protein) and is the rate limiting step in ovarian steroidogenesis 3 β HSD: Hydroxysteroid dehydrogenenase

Figure 2: Ovarian steroidogenesis: Granulosa cells form the inner lining of the ovarian follicle. The thecal cells abut them and form the outer layer. Granulosa cells are dependent on the diffusing androstenedione from the theca cells for substrate as they are not in direct connection with the circulation (Two cell hypothesis). All steroid hormones are derived from cholesterol. Its entry into the mitochondria is mediated by StAR (Steroidogenic acute regulatory protein) and is the rate limiting step in ovarian steroidogenesis 3 β HSD: Hydroxysteroid dehydrogenenase